参考文献/References:
[1] 肖亚平,曾杰,焦琳娜,等.补肾中药对骨质疏松症的治疗及其信号通路调节作用的研究进展[J].中国中药杂志,2018,43(1):21-30.
[2] WU Y Q,CAO L Y,XIA L G,et al.Evaluation of osteogenesis and angiogenesis of icariin in local controlled release and systemic delivery for calvarial defect in ovariectomized rats[J].Scientific Reports,2017,7(1):5077.
[3] QIAN W Q,SU Y,ZHANG Y J,et al.Secretome analysis of rat osteoblasts during icariin treatment induced osteogenesis[J].Molecular Medicine Reports,2018,17(5):6515-6525.
[4] ZHANG G Y,CHENG X F,ZHOU G S,et al.New pathway of icariin-induced MSC osteogenesis:transcriptional activation of TAZ/Runx2 by PI3K/Akt[J].Open Life Sciences,2017,12(1):228-236.
[5] ZHANG S S,XUE R,HU R Z.The neuroprotective effect and action mechanism of polyphenols in diabetes mellitus-related cognitive dysfunction[J].European Journal of Nutrition,2020,59(4):1295-1311.
[6] MAAS S L N,BREAKEFLELD X O,WEAVER A M.Extracellular vesicles:unique intercellular delivery vehicles[J].Trends in Cell Biology,2017,27(3):172-188.
[7] VADER P,BREAKEFLELD X O,WOOD M J A.Extracellular vesicles:emerging targets for cancer therapy[J].Trends in Molecular Medicine,2014,20(7):385-393.
[8] ANDALOUSSI S E L,M?GER I,BREAKEFIELD X O,et al.Extracellular vesicles:biology and emerging therapeutic opportunities[J].Nature Reviews Drug Discovery,2013,12(5):347-357.
[9] ALVAREZ-ERVITI L,SEOW Y,YIN H F,et al.Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes[J].Nature Biotechnology,2011,29(4):341-345.
[10] ZHOU J Q,TAN X H,TAN Y H,et al.Mesenchymal stem cell derived exosomes in Cancer progression,metastasis and drug delivery:a comprehensive review[J].Journal of Cancer,2018,9(17):3129-3137.
[11] AGI A,JUNIN R,YAHYA A,et al.Comparative study of continuous and intermittent ultrasonic ultrafiltration membrane for treatment of synthetic produced water containing emulsion[J]. Chemical Engineering and Processing:Process Intensification,2018,132:137-147.
[12] AGRAWAL A,AQIL F,JEYABALAN J,et al.Milk-derived exosomes for oral delivery of paclitaxel[J].Nanomedicine,2017,13(5):1627-1636.
[13] ZHENG D,PENG S L,YANG S H,et al.The beneficial effect of Icariin on bone is diminished in osteoprotegerin-deficient mice[J].Bone,2012,51(1):85-92.
[14] 娄鸣,李晓红,饶国洲. BMP-2, BGP mRNA表达量及ALP活性的变化对大鼠骨髓间充质干细胞体外诱导成骨细胞的影响[J]. 现代检验医学杂志,2008,23(5):28-31.
[15] DUCY P,SCHINKE T,KARSENTY G.The osteoblast:a sophisticated fibroblast under central surveillance[J].Science,2000,289(5484):1501-1504.
[16] LEE K S,KIM H J,LI Q L,et al.Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2,and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12[J].Mol Cell Biol,2000,20(23):8783-8792.
[17] VIMALRAJ S,ARUMUGAM B,MIRANDA P J,et al.Runx2:structure,function,and phosphorylation in osteoblast differentiation[J].Int J Biol Macromol,2015,78:202-208.