[1]陈达,彭力平△,余阗,等.“六味骨痹汤”治疗膝骨关节炎疗效及安全性的临床研究[J].中国中医骨伤科杂志,2017,25(05):26-29.
　CHEN Da PENG Liping YU Tian LIAO Zhouwei TAN Ruiquan MA Dujun.Clinical Research on the Efficacy and Safety of “Liuweigubi Decoction” in Treating Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2017,25(05):26-29.
点击复制

“六味骨痹汤”治疗膝骨关节炎疗效及安全性的临床研究()
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第25卷
期数:
2017年05期
页码:
26-29
栏目:
临床研究
出版日期:
2017-05-08

文章信息/Info

Title:
Clinical Research on the Efficacy and Safety of “Liuweigubi Decoction” in Treating Knee Osteoarthritis
文章编号:
1005-0205(2017)05-0026-04
作者:
陈达1;  彭力平2△;  余阗2;  廖州伟1;  谭锐泉2;  马笃军2
1.广州中医药大学第四临床医学院(广东 深圳,518033)
2.深圳市中医院
△.通信作者 E-mail:plp001@sina.com
Author(s):
CHEN Da1 PENG Liping2△ YU Tian2 LIAO Zhouwei1 TAN Ruiquan2 MA Dujun2
1.The Fourth Clinical Medical College,Affiliated to Guangzhou University of Traditional Chinese Medicine,Shenzhen 518033,Guangdong China;
2.Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen 518033,Guangdong China.
关键词:
六味骨痹汤;  膝骨关节炎;  硫酸氨基葡萄糖;  疗效观察;  安全性评价
Keywords:
Liuweigubi decoction;  osteoarthritis;  glucosamine sulfate;  efficacy observation;  safety evaluation
分类号:
R684.3
文献标志码:
A
摘要:
目的:观察、评价“六味骨痹汤”治疗膝骨关节炎的疗效及安全性。方法:将60例肝肾亏虚型膝骨关节炎患者随机分为2组,每组30例。治疗组接受“六味骨痹汤”治疗,对照组接受硫酸氨基葡萄糖治疗,连续治疗6周。采用VAS评分、Lequesne指数作为疗效评价标准,比较两组患者服药前后主观疼痛变化,观察膝关节症状(包括休息痛、运动痛、压痛、肿胀、晨僵和行走能力)的改善程度,并记录用药期间不良反应、生命体征及实验室生化指标等。结果:治疗后两组各项临床评分较治疗前均显著好转,与治疗前差异有统计学意义(P<0.05),治疗后两组间差异无统计学意义(P>0.05); 治疗组无明显不良反应发生,不良反应率低于对照组,差异无统计学意义(P>0.05)。结论:“六味骨痹汤”可有效降低VAS评分及Lequesne指数,对膝骨关节炎疗效良好,安全性高,值得临床推广使用。
Abstract:
Objective:To observe and evaluate the efficacy and safety of “Liuweigubi decoction” in treating knee osteoarthritis.Methods:All 60 patients with liver and kidney deficiency type of knee osteoarthritis were randomly divided into 2 groups,30 cases in each group.Patients in the treatment group were treated with “Liuweigubi decoction”,while the control group were treated with glucosamine sulfate,continuous treatment for 6 weeks.The VAS score and Lequesne index were used as criteria for evaluation of the efficacy.The changes of the subjective pain in patients of two groups before and after taking were compared,the improvement degree of knee symptoms including pain at rest and movement,tenderness,swelling,morning stiffness and walking ability were observed,and the adverse reactions,vital signs and laboratory biochemical indexes during the treatment were record.Results:After treatment,the clinical scores of the two groups were significantly improved compared with before treatment(P<0.05),and there was no significant difference between the two groups(P>0.05).There was no obvious adverse reaction in the treatment group,and the rate of the adverse reaction was lower than that of the control group,there was no statistically significant difference(P>0.05).Conclusion:“Liuweigubi decoction” can reduce the VAS score and Lequesne index effectively,which has good efficacy and high safety in treating knee osteoarthritis,and it is worthy of clinical application.

参考文献/References:

[1] 阳乐,许鹏.促炎细胞因子与骨关节炎[J].中华骨与关节外科杂志,2015,8(5):455-459.
[2] 施玲玲,陈东煜.膝关节骨关节炎的中医药治疗现状[J].中国中医骨伤科杂志,2014,22(7):72-74.
[3] 中华医学会骨科学分会.骨关节炎诊治指南(2007年版)[J].中国临床医生,2008,42(1):28-30.
[4] 国家食品药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:349.
[5] Lequesne MG,Samson M.Indices of severity in osteoarthritis for weight bearing joints[J].J Rheumatol Suppl,1991,27:16-18.
[6] 陆艳红,石晓兵.膝骨关节炎国内外流行病学研究现状及进展[J].中国中医骨伤科杂志,2012,20(6):81-84.
[7] 刘搏宇,李宏宇.骨性关节炎治疗方法的研究进展[J].医学综述,2015,21(24):4499-4501.
[8] 李树明.中医治疗膝骨性关节炎临床疗效观察[J].内蒙古中医药,2014,33(27):18-19.
[9] 张新玉,魏丽.骨关节炎发病机理的研究进展[J].河北医学,2016,22(4):666-668.
[10] 许学猛.中医治疗膝痹(骨关节炎)的特色疗法[N].中国中医药报,2015-11-13-5.
[11] 陈浩雄,徐宁达,彭力平,等.中药治疗膝骨关节炎软骨修复实验研究进展[J].现代中西医结合杂志,2014,23(25):2843-2845.
[12] 陈达,廖州伟,马笃军,等.牛膝醇提物对兔骨关节炎模型的疗效比较[J].中国医药导报,2016,13(25):21-24.
[13] 蔡奇文,邱德华,张建伟,等.石仰山论治膝骨关节病经验[J].中国中医骨伤科杂志,2016,24(2):74-75.
[14] 国家中医药管理局“十一五”重点专科协作组.膝痹病(膝关节骨性关节炎)诊疗方案[M].北京:人民卫生出版社,2009:18-19.
[15] 李具宝,张磊,屈尚可,等.膝骨关节炎近10年文献中内服方药功效和中医证型分析[J].中国中医骨伤科杂志,2014,22(3):20-21.

更新日期/Last Update: 2017-05-01