参考文献/References:
[1] PALACIOS S.Medical treatment of osteoporosis[J].Climacteric,2022,25(1):43-49.
[2] ZHANG Y,JIANG Y,LUO Y,et al.Interference of miR-212 and miR-384 promotes osteogenic differentiation via targeting RUNX2 in osteoporosis[J].Exp Mol Pathol,2020,113(1):104366-104367.
[3] AL-AZAB M,WALANA W,WEI J,et al.TL1A/TNFR2 axis enhances immunoregulatory effects of bone marrow derived mesenchymal stem cell by indian hedgehog signaling pathway[J].Int J Stem Cells,2021,14(1):58-73.
[4] AL-AZAB M,WANGB,ELKHIDER A,et al.Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1,p70S6K1/2 pathway[J].Aging(Albany NY),2020,12(7):5693-5715.
[5] BANDOPADHYAY S,ANAND U,GADEKAR V S,et al.Dioscin:a review on pharmacological properties and therapeutic values[J].Biofactors,2022,48(1):22-55.
[6] YIN W,LIU S,DONG M,et al.A new NLRP3 inflammasome inhibitor,dioscin,promotes osteogenesis[J].Small,2020,16(1):1905977-1905978.
[7] 陈学武,王弘.薯蓣皂苷对破骨细胞分化及骨吸收功能的调控作用及机制研究[J].中国临床药理学杂志,2022,38(6):523-527.
[8] 赖满香,廖利平,林基伟,等.梓醇调控Hedgehog信号通路促进BMSCs向成骨分化的实验研究[J].免疫学杂志,2019,35(11):921-926.
[9] REID I R.A broader strategy for osteoporosis interventions[J].Nat Rev Endocrinol,2020,16(6):333-339.
[10] QIU M,ZHAI S,FU Q,et al.Bone marrow mesenchymal stem cells-derived exosomal microrna-150-3p promotes osteoblast proliferation and differentiation in osteoporosis[J].Hum Gene Ther,2021,32(13):717-729.
[11] 周琦,孙慧娟,刘树民.穿山龙总皂苷调控巨噬细胞M1/M2极化治疗痛风性关节炎的作用机制[J].中国实验方剂学杂志,2021,27(24):92-99.
[12] ZHANG L,NI R,LI J,et al.Dioscin regulating bone marrow apoptosis in aplastic anemia[J].Drug Des Devel Ther,2022,16(1):3041-3053.
[13] 李菁,陈盈,滕伟,等.载基因脂多糖胺纳米囊泡诱导BMSCs定向成骨分化[J].中国修复重建外科杂志,2018,32(11):1469-1476.
[14] QI X,LI X.Mechanistic insights into the generation and transduction of hedgehog signaling[J].Trends Biochem Sci,2020,45(5):397-410.
[15] TAKEBE H,SHALEHIN N,HOSOYA A,et al.Sonic Hedgehog regulates bone fracture healing[J].Int J Mol Sci,2020,21(2):677-678.
[16] CHEN L,LIU G,LI W,et al.Synergistic effects of Indian Hedgehog and sonic Hedgehog on chondrogenesis during cartilage repair[J].J Mol Histol,2021,52(2):407-418.
[17] JIA Y,LU T,CHEN Q,et al.Exosomes secreted from sonic Hedgehog-modified bone mesenchymal stem cells facilitate the repair of rat spinal cord injuries[J].Acta Neurochir(Wien),2021,163(8):2297-2306.
[18] LIU D D,ZHANG C Y,LIU Y,et al.RUNX2 regulates osteoblast differentiation via the BMP4 signaling pathway[J].J Dent Res,2022,101(10):1227-1237.
[19] KOMORI T.Molecular mechanism of Runx2-dependent bone development[J].Mol Cells,2020,43(2):168-175.
[20] 程英雄,罗毅文,王斌,等.补肾活血汤调控Runx2及Osterix促进BMSCs成骨分化的作用研究[J].中国中医基础医学杂志,2018,24(8):1085-1088.
[21] RADHAKRISHNAN A,ROHATGI R,SIEBOLD C.Cholesterol access in cellular membranes controls Hedgehog signaling[J].Nat Chem Biol,2020,16(12):1303-1313.
[22] SHENG M,LIN Y,XU D,et al.CD47-mediated Hedgehog/SMO/GLI1 signaling promotes mesenchymal stem cell immunomodulation in mouse liver inflammation[J].Hepatology,2021,74(3):1560-1577.
[23] ZHONG L N,ZHANG Y Z,LI H,et al.Overexpressed miR-196a accelerates osteogenic differentiation in osteoporotic mice via GNAS-dependent Hedgehog signaling pathway[J].J Cell Biochem,2019,120(12):19422-19431.