[1]潘旭月 邓品 王梅青 陈兆军△.复方血竭粉治疗糖尿病足溃疡创面的临床研究[J].中国中医骨伤科杂志,2022,30(07):32-37.
　PAN Xuyue DENG Pin WANG Meiqing CHEN Zhaojun.Clinical Research of Fufang Xuejie Powder on the Treatment of Diabetic Foot Ulcer[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2022,30(07):32-37.
点击复制

复方血竭粉治疗糖尿病足溃疡创面的临床研究()
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第30卷
期数:
2022年07期
页码:
32-37
栏目:
临床研究
出版日期:
2022-07-15

文章信息/Info

Title:
Clinical Research of Fufang Xuejie Powder on the Treatment of Diabetic Foot Ulcer
文章编号:
1005-0205(2022)07-0032-06
作者:
潘旭月1 邓品2 王梅青3 陈兆军1△
1北京中医药大学第三附属医院手足外科(北京,100029)2北京中医药大学3北京清华长庚医院
Author(s):
PAN Xuyue1 DENG Pin2 WANG Meiqing3 CHEN Zhaojun1△
1Department of Hand and Foot Surgery,the Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China; 2Beijing University of Chinese Medicine,Beijing 100029,China; 3Beijing Tsinghua Changgung Hospital,Beijing 102218,China.
关键词:
复方血竭粉;  糖尿病足;  去腐生肌
Keywords:
Xuejie powder;  diabetic foot;  dispelling decay and promoting muscle growth
分类号:
R587.2
文献标志码:
A
摘要:
目的:探讨复方血竭粉在促进治疗糖尿病足溃疡愈合中的作用。方法:选取2018年4月至2020年4月住院的糖尿病足患者,纳入符合标准的病例80例,其中治疗组及对照组各40例,两组病例基本资料及病情差异无统计学意义。治疗组采用清创换药+复合血竭粉方法,对照组采用单纯清创换药的方法。对比观察两组在临床综合疗效、患肢疼痛视觉模拟评分法(VAS)评分、红肿消退时间、创面愈合速率及脓液量等的差异。结果:临床综合疗效方面:治疗组治愈20例,显效6例,有效8例,无效6例,总有效率为85%; 对照组治愈10例,显效9例,有效5例,无效16例,总有效率为60%; 两组疗效比较差异有统计学意义(P<0.05)。两组在治疗后1个月及半年随访时VAS评分均较前明显改善,治疗组VAS评分由治疗前的(5.15±1.14)分降至治疗后1个月的(1.30±0.92)分及随访时的(0.65±0.75)分,对照组疼痛VAS评分由治疗前的(5.06±1.44)分降至治疗后1个月的(3.00±1.03)分及随访时的(1.69±0.95)分,两组之间差异有统计学意义(P<0.05)。治疗组在红肿消退时间及创面愈合时间方面明显优于对照组,差异有统计学意义(P<0.05),但两组脓液量差异无统计学意义(P>0.05)。结论:复方血竭粉在促进糖尿病足创口愈合、缓解创口疼痛、促进红肿消退等方面疗效显著,且优于一般清创换药,可治疗糖尿病足创面。
Abstract:
Objective:To explore the efficacy of Xuejie powder in promoting the healing of diabetic foot ulcers.Methods:Patients with diabetic foot patients hospitalized in hospital from April 2018 to April 2020 were selected including 80 eligible cases,with 40 cases in each group.There was no significant statistical difference in the basic data and the condition between two groups.The treatment group used the method of debridement and dressing Xuejie powder,and the control group used the method of debridement and dressing petrolatum ointment.The differences in clinical comprehensive efficacy,pain visual analogue scale(VAS)scores,redness,swelling subsided time,wound healing rate and pus volume were compared and observed between the two groups.Results:Clinical comprehensive efficacy:20 cases were cured in the treatment group,6 cases were markedly effective,8 cases were effective,6 cases were ineffective,and the total effective rate was 85%.In the control group,10 cases were cured,9 cases were markedly effective,5 cases were effective,16 cases were ineffective,and the total effective rate was 60%.The difference in efficacy between the two groups was significant(P<0.05).The VAS scores of the two groups were significantly improved at 1 month and half a year after treatment.The VAS scores of the treatment group decreased from 5.15±1.14 before treatment to 1.30±0.92 at 1 month after treatment and 0.65±0.75 at follow-up.The pain scores of the control group decreased from 5.06±1.44 before treatment to 3.00±1.03 at 1 month after treatment and 1.69±0.95 at follow-up,however,the difference between the two groups was statistically significant(P<0.05).The redness and swelling subsided time and wound healing time in treatment group were significantly better than that of the control group,and the difference was statistically significant(P<0.05),but there was no statistically significant difference in the amount of pus between the two groups(P>0.05).Conclusion:The Xuejie powder is effective in promoting the healing of diabetic foot wounds,relieving wound pain and promoting redness and swelling,which is better than the general debridement and dressing change group.It can treat diabetic foot ulcer.

参考文献/References:

[1] 田林,时孝晴,段正兰,等.胫骨横向骨搬移术治疗糖尿病足疗效及安全性的Meta分析[J].中国组织工程研究,2021,25(20):3275-3280.
[2] 李新民,谢丽君,安俊丽.糖尿病足患者生存质量现状调查及影响因素分析[J].四川解剖学杂志,2020,28(4):48-49.
[3] BROD M.Quality of life issues in patients with diabetes and lower extremity ulcers:patients and care givers[J].Qual Life Res,1998,7(4):365-372.
[4] ASHRY H R,LAVERY L A,ARMSTRONG D G,et al.Cost of diabetes-related amputations in minorities[J].Foot Ankle Surg,1998,37(3):186-190.
[5] 中华医学会糖尿病学分会,中华医学会感染病学分会,中华医学会组织修复与再生分会.中国糖尿病足防治指南(2019版)[J].中华糖尿病杂志,2019,11(2):92-108.
[6] LAVERY L A,ARMSTRONG D G,HARKLESS L B.Classication of diabetic foot wounds[J].J Foot Ankle Surg,1996,35(6):528-531.
[7] BREIVIK H.Fifty years on the Visual Analogue Scale(VAS)for pain-intensity is still good for acute pain:but multidimensional assessment is needed for chronic pain[J].Scand J Pain,2016,11:150-152.
[8] 王可仪,欧益,刘春香,等.中医药治疗糖尿病足临床研究结局指标分析[J].中国中药杂志,2021,46(15):4008-4015.
[9] 中国微循环学会周围血管疾病专业委员会糖尿病足学组.糖尿病足创面修复治疗专家共识[J].中华糖尿病杂志,2018,10(5):305-309.
[10] 唐汉均,徐杰,蒉刚.中医外治纲要(下)——中医外治机理探讨与证治知要[J].中医外治杂志,2014,23(5):7.
[11] 杜玉青,李友山,刘亚莉,等.生肌玉红膏治疗糖尿病足溃疡疗效的系统评价[J].世界中医药,2021,16(22):3342-3347.
[12] 杨镇旭,王骁汉,韩超然,等.生肌玉红膏近5年临床研究进展[J].中医临床研究,2021,13(5):139-142.
[13] 易军,许来宾,王万春.生肌玉红膏在皮肤慢性溃疡中的临床运用研究进展[J].江西中医药大学学报,2021,33(3):117-120.
[14] 杨丽晗,张志毕,杨晖,等.两种血竭凝胶抗炎抗菌效果比较[J].昆明医科大学学报,2021,42(1):6-11.
[15] 张海霞,李旗,田福玲,等.中医药治疗糖尿病足研究进展[J].海南医学院学报,2020,26(8):637-640.
[16] 中国中西医结合学会周围血管病专业委员会.中西医结合防治糖尿病足中国专家共识(第1版)[J].血管与腔内血管外科杂志,2019,5(5):379-402.
[17] 姚昶,陈德轩,卞卫和,等.生肌玉红胶原促进大鼠后肢缺血组织血管新生的实验研究[J].中国普外基础与临床杂志,2013,20(4):389-394.
[18] 刘佳莅,姜伟华,夏成勇,等.生肌玉红膏联合封闭负压引流术对糖尿病足患者溃疡创面血管新生及氧化应激指标的影响[J].湖南中医药大学学报,2019,39(2):257-261.
[19] 王军,张庚扬,侯玉芬,等.糖尿病足溃疡期中医综合外治方案规范的多中心临床研究[J].北京中医药大学学报(中医临床版),2013,20(2):15-18.
[20] 付利红,柯有力.封闭式负压引流术结合丹红注射液治疗糖尿病足溃疡临床观察[J].实用中医药杂志,2020,36(12):1579-1580.
[21] 周晓芳.糖尿病足的创面修复的临床效果分析[J].实用糖尿病杂志,2020,16(6):77-78.
[22] 佟爱华,张金华,葛明芹,等.高压氧联合硫辛酸治疗糖尿病足的机制及对截肢的预防作用研究[J].中华航海医学与高气压医学杂志,2020,27(5):553-556.
[23] 王璐宁,关小宏,吴石白,等.负压封闭引流技术治疗糖尿病足慢性创面的疗效分析[J].中国医药,2014,9(12):1761-1765.
[24] 顾洪斌.糖尿病足溃疡的外科血管重建与修复手术[J].中华糖尿病杂志,2021,13(1):50-53.
[25] 袁小燕.糖尿病足感染患者病原菌分布及耐药情况分析[J].中国社区医师,2021,37(1):6-7.

备注/Memo

备注/Memo:
基金项目:北京中医药大学青年教师项目(2017-JYB-JS-119)
△通信作者 E-mail:zhaojunchen66@126.com
更新日期/Last Update: 1900-01-01