[1]谭学松 匡浩铭 熊杰 洪政茹 常裕绅 院一蔚 戎宽 匡建军△.恒古骨伤愈合剂治疗肝肾亏虚型膝骨关节炎30例[J].中国中医骨伤科杂志,2021,29(08):44-47.
 TAN Xuesong KUANG Haoming XIONG Jie HONG ZhengruCHANG Yushen YUAN Yiwei RONG Kuan KUANG Jianjun.30 Cases Clinical Observation of Osteoking on KneeOsteoarthritis of Liver and Kidney Deficiency[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2021,29(08):44-47.
点击复制

恒古骨伤愈合剂治疗肝肾亏虚型膝骨关节炎30例()
分享到:

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第29卷
期数:
2021年08期
页码:
44-47
栏目:
临床报道
出版日期:
2021-08-15

文章信息/Info

Title:
30 Cases Clinical Observation of Osteoking on KneeOsteoarthritis of Liver and Kidney Deficiency
文章编号:
1005-0205(2021)08-0044-04
作者:
谭学松1 匡浩铭1 熊杰1 洪政茹1 常裕绅1 院一蔚1 戎宽2 匡建军3△
1湖南中医药大学(长沙,410208)2湖南省中医药研究院附属医院3湖南省中医药研究院
Author(s):
TAN Xuesong1 KUANG Haoming1 XIONG Jie1 HONG Zhengru1CHANG Yushen1 YUAN Yiwei1 RONG Kuan2 KUANG Jianjun3△
1Hunan University of Chinese Medicine, Changsha 410208, China; 2The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha 410006, China; 3Hunan Academy of Chinese Medicine, Changsha 410006, China.
关键词:
恒古骨伤愈合剂 膝骨关节炎 肝肾亏虚证 临床观察
Keywords:
osteoking knee osteoarthritis liver and kidney deficiency syndrome clinical observation
分类号:
R684.3
文献标志码:
B
摘要:
目的:通过观察恒古骨伤愈合剂对膝骨关节炎患者的症状改善情况,评价恒古骨伤愈合剂的临床疗效。方法:将60例门诊患者随机分为恒古组及对照组,每组各30例。对照组口服盐酸氨基葡萄片(0.48 g/次,3次/d),辅以股四头肌锻炼; 恒古组口服恒古骨伤愈合剂(每次25 mL,隔天1次),辅以股四头肌锻炼,两组都治疗3个月,分析治疗前后患者中医证候疗效、WOMAC指数、VAS评分、满意度,评价治疗效果。结果:两组患者治疗前一般资料比较差异无统计学意义(P>0.05); 两组治疗后中医证候疗效、WOMAC指数、VAS评分、满意度差异均有统计学意义(P<0.05)。结论:恒古骨伤愈合剂辅以股四头肌锻炼,可以明显缓解膝关节疼痛,增强膝关节稳定性,恢复关节功能,提高日常生活质量,且患者依从性及满意度更高,值得临床推广应用。
Abstract:
To observe the symptom improvement of osteoking on knee osteoarthritis patients, the clinical efficacy of osteoking was evaluated.Methods: 60 outpatients were randomly divided into Henggu group and basic group, with 30 cases in each group.The basic group took oral amino-grape hydrochloride tablets(0.48 g each time, 3 times a day), supplemented by quadriceps exercise, the Henggu group takes oral osteoking(25 mL each time,every other day), supplemented by thigh quadriceps exercises, the two groups were treated at the same time for 3 months.The efficacy of TCM syndromes, WOMAC index, VAS score, and satisfaction before and after treatment were analyzed to evaluate the treatment effect.Results: There was no significant difference in the general data of the two groups of patients before treatment(P>0.05).The efficacy of TCM syndromes, WOMAC index, VAS score, and satisfaction were significantly better in Henggu group as compared with it in basic group(P<0.05).Conclusion: Osteoking supplemented with quadriceps exercise, can significantly relieve knee joint pain, enhance knee joint stability, restore joint function, improve the quality of daily life, and have higher patient compliance and satisfaction.It is worthy of clinical promotion application.

参考文献/References:

[1] 陆艳红,石晓兵.膝骨关节炎国内外流行病学研究现状及进展[J].中国中医骨伤科杂志,2012,20(6):81-84.
[2] QIN D,ZHANG H J,ZHANG H F,et al.Anti-osteoporosis effects of osteoking via reducing reactive oxygen species[J].J Ethnopharmacol,2019,244:112045.
[3] 蒙锡波,邓丽丽.恒古骨伤愈合剂联合活血补肾汤治疗激素性股骨头坏死疗效及对骨密度的影响[J].现代中西医结合杂志,2018,27(1):82-85.
[4] 何帮剑,毛强,华江,等.恒古骨伤愈合剂在胫骨中下段骨折术后的应用及作用机制[J].中医正骨,2020,32(5):15-18.
[5] 曹闲雅,匡浩铭,苏翔,等.恒古骨伤愈合剂治疗腰椎间盘突出症肾虚血瘀证的临床研究[J].湖南中医药大学学报,2020,40(12):1548-1552.
[6] 陈剑明,徐丁,汪帅伊,等.恒古骨伤愈合剂治疗绝经后骨质疏松症的临床研究[J].中国中医骨伤科杂志,2020,28(8):46-49.
[7] HOCHBERG M C,ALTMAN R D,BRANDT K D,et al.Guidelines for the medical management of osteoarthritis.Part Ⅱ.Osteoarthritis of the knee.American College of Rheumatology[J].Arthritis Rheum,1995,38(11):1541-1546.
[8] 中华中医药学会骨伤科分会膝痹病(膝骨关节炎)临床诊疗指南制定工作组.中医骨伤科临床诊疗指南·膝痹病(膝骨关节炎)[J].康复学报,2019,29(3):1-7.
[9] COMPSTON J.Monitoring osteoporosis treatment[J].Best Pract Res Clin Rheumatol,2009,23(6):781-788.
[10] 国家食品药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:349-353.
[11] DAVIDOVITCH R I,JORDAN C J,EGOL K A,et al.Challeges in the treatment of femoral neck fractures in the nonelderly adult[J].J Treauma,2010,68(1):236-242.
[12] 郑晓芬.骨关节炎发病机制和治疗的最新进展[J].中国组织工程研究,2017,21(20):3255-3262.
[13] GOLDRING M, BERENBAUM F.Emerging targets in osteoarthritis therapy[J].Curr Opin Pharmacol,2015,22:51-63.
[14] HENROTIN Y,LAMBERT C.Chondroitin and glucosamine in the management of osteoarthritis:an update[J].Curr Rheumatol Rep,2013,15(10):361-365.
[15] 周帅琪,梁龙,于杰,等.最新膝骨关节炎循证国际指南纵览[J].海南医学院学报,2020,26(5):388-391.
[16] 刘福英,刘卫华.股四头肌等长等张收缩锻炼在治疗膝骨关节炎中的作用[J].中国医药科学,2013,15(3):40-42.
[17] 谭开云,卢敏.加味独活寄生合剂治疗风寒湿痹、肝肾亏虚型膝骨关节炎临床疗效观察[J].中华中医药学刊,2016,34(2):425-427.
[18] JEONG H J,KOO H N,NA H J,et al.Inhibition of TNF-α and IL-6 production by aucubin through blockade of NF-κB activation in RBL-2H3 mast cells[J].Cyto-Kine,2002,18(5):252-259.
[19] RIGOGLOU S, PAPAVASSILIOU A G.The NF-κB signalling pathway in osteoarthritis[J].Int J Biochem Cell Biol,2013,45(11):2580-2584.
[20] TROEBERG L,NAGASE H.Proteases involved in cartilage matrix degradation in osteoarthritis[J].Biochim Biophys Acta,2012,1824:133-145.
[21] LIN J,FAN Y J,MEHL C,et al.Eucommia ulmoides Olivantagonizes H2O2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3,6,7,and 9[J].J Zhejiang Univ:Sci B,2011,12(1):47-54.
[22] LI Y,WANG M J,LI S,et al.Effect of total glycosides from Eucommia ulmoides seed on bone microarchitecture in rats[J].Phytother Res,2011,25(12):1895-1897.

备注/Memo

备注/Memo:
基金项目:国家中医药管理局全国名老中医药专家传承工作室建设项目湖南省科技厅课题(2019ZK4021)湖南省科技厅课题(2020ZK4070)
通信作者 E-mail:13786165656@163.com
更新日期/Last Update: 2021-08-15