[1]孔令岩 柴仪△ 李倩 常波伦 刘烁炜 暴凯 麻丛丛.淫羊藿总黄酮和黄芪多糖配伍对骨质疏松大鼠的保护作用[J].中国中医骨伤科杂志,2021,29(04):24-26.
　KONG Lingyan CHAI Yi LI Qian CHANG BolunLIU Shuowei BAO Kai MA Congcong.Protective Effect of the Compatibility of Epimedium Flavonoidsand Astragalus Polysaccharides on Osteoporosis Rats[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2021,29(04):24-26.
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淫羊藿总黄酮和黄芪多糖配伍对骨质疏松大鼠的保护作用()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第29卷
期数:
2021年04期
页码:
24-26
栏目:
实验研究
出版日期:
2021-04-15

文章信息/Info

Title:
Protective Effect of the Compatibility of Epimedium Flavonoidsand Astragalus Polysaccharides on Osteoporosis Rats
文章编号:
1005-0205(2021)04-0024-03
作者:
孔令岩1 柴仪1△ 李倩2 常波伦1 刘烁炜1 暴凯1 麻丛丛3
1河北省中医院(石家庄,050011)
2河北友爱医院
3承德医学院
Author(s):
KONG Lingyan1 CHAI Yi1△ LI Qian2 CHANG Bolun1LIU Shuowei1 BAO Kai1 MA Congcong3
1Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,China; 2Hebei Friendship Hospital,Shijiazhuang 050031,China; 3Chengde Medical University,Chengde 067000,Hebei China.
关键词:
淫羊藿总黄酮;  黄芪多糖;  大鼠;  骨质疏松症;  补肾健脾
Keywords:
epimedium flavonoids;  astragalus polysaccharides;  rats;  osteoporosis;  tonifying the kidney and strengthening the spleen
分类号:
R-33
文献标志码:
A
摘要:
目的:观察淫羊藿总黄酮和黄芪多糖配伍对去势骨质疏松大鼠的保护作用。方法:采用双侧卵巢切除术复制大鼠骨质疏松(OP)模型,将50只SD大鼠随机分为正常组、模型组、淫羊藿总黄酮组、黄芪多糖组和淫羊藿总黄酮+黄芪多糖组(各10只),分别给予相应药物灌胃,正常组和模型组给予等体积生理盐水。12周后处死大鼠,取血测定血钙(Ca)、血磷(P)、骨钙素(BGP),取左侧股骨,测定骨干质量、骨灰质量、骨Ca及骨P的含量。结果:淫羊藿总黄酮组、黄芪多糖组及淫羊藿总黄酮+黄芪多糖组均能改善血Ca、血P和BGP水平,增加骨干重、骨灰重、骨Ca及骨P的含量,差异有统计学意义(P<0.05); 与单味药组相比,淫羊藿总黄酮+黄芪多糖组的作用尤为显著,差异有统计学意义(P<0.05)。结论:淫羊藿总黄酮和黄芪多糖配伍可有效改善去卵巢大鼠的骨质疏松,为补肾健脾法的临床应用提供了实验依据。
Abstract:
To study the protective effects of epimedium flavonoids and astragalus polysaccharides on osteoporosis rats.Methods:50 SD rats were randomly divided into normal group(n=10),model group(n=10),epimedium flavonoids group(n=10),astragalus polysaccharides group(n=10)and epimedium flavonoids + astragalus polysaccharides group(n=10).Each group was given corresponding drugs by gavage,and the normal group and model group were given equal volume of normal saline.After 12 weeks,all the rats were killed.The blood calcium(Ca),blood phosphorus(P)and Osteocalcin(BGP)were measured.The left femur was taken to measure the bone weight,bone ash weight,bone Ca and bone P content.Results:The levels of blood Ca,P and BGP were improved,and the contents of bone Ca,bone ash,bone Ca and bone P were increased in the group of epimedium flavonoids,astragalus polysaccharide and epimedium flavonoids + astragalus polysaccharides group(P<0.05).The effect of epimedium flavonoids + astragalus polysaccharide group was more significant than the single drug group(P<0.05).Conclusion:The combination of epimedium flavonoids and astragalus polysaccharides can effectively improve osteoporosis in ovariectomized rats,which provides experimental basis for the clinical application of tonifying the kidney and strengthening the spleen.

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备注/Memo

备注/Memo:
基金项目:河北省中医药管理局资助项目(219001)
△通信作者 E-mail:290507602@qq.com
更新日期/Last Update: 2021-04-15