[1]林巧璇 刘晶 卢莉铭 郭泽兴 刘洪 张良志 曾维铨 修忠标.补肾活血汤对骨质疏松性椎体压缩性骨折PKP术后患者疼痛和骨代谢的影响[J].中国中医骨伤科杂志,2021,29(03):21-26.
　LIN Qiaoxuan LIU Jing LU Liming GUO Zexing LIU Hong ZHANG Liangzhi ZENG Weiquan XIU Zhongbiao.Study on Effect of Bushenhuoxue Decoction for Pain and Bone Metabolism in Patients with Osteoporotic Vertebral Compression Fracture after PKP Operation[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2021,29(03):21-26.
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补肾活血汤对骨质疏松性椎体压缩性骨折PKP术后患者疼痛和骨代谢的影响()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第29卷
期数:
2021年03期
页码:
21-26
栏目:
临床研究
出版日期:
2021-03-15

文章信息/Info

Title:
Study on Effect of Bushenhuoxue Decoction for Pain and Bone Metabolism in Patients with Osteoporotic Vertebral Compression Fracture after PKP Operation
文章编号:
1005-0205(2021)03-0021-06
作者:
林巧璇 刘晶 卢莉铭 郭泽兴 刘洪 张良志 曾维铨 修忠标
1福建中医药大学中医学院(福州,350122)2福建中医药大学附属人民医院3中医骨伤及运动康复教育部重点实验室4福建省骨伤研究所△通信作者
Author(s):
LIN Qiaoxuan LIU Jing LU Liming GUO Zexing LIU Hong ZHANG Liangzhi ZENG Weiquan XIU Zhongbiao
1College of Traditional Chinese Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122, China; 2The People’s Hospital Affiliated of Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China; 3Key Laboratory of Orthopedics & Traumatology and Rehabilitation of Traditional Chinese Medicine,Ministry of Education,Fuzhou 350122,China; 4Fujian Institute of Orthopaedics,Fuzhou 350004,China.
关键词:
补肾活血汤;  骨质疏松性椎体压缩性骨折;  经皮椎体后凸成形术;  骨代谢
Keywords:
Bushenhuoxue decoction;  osteoporotic vertebral compression fracture;  percutaneous kyphoplasty;  bone metabolism
分类号:
R683.2
文献标志码:
A
摘要:
目的:观察补肾活血汤对骨质疏松性椎体压缩性骨折(OVCF)经皮椎体后凸成形术(PKP)术后患者疼痛和血清骨代谢的改善作用。方法:70例OVCF术后患者采用随机数字表法随机分为观察组和对照组,观察组给予补肾活血汤结合常规抗骨质疏松药物治疗; 对照组予常规抗骨质疏松药物治疗,连续服用6个月。比较治疗前后两组视觉模拟评分法(VAS)评分、日常生活能力评定(ADL)、骨密度、血清骨代谢指标(BGP,PINP,IL-6,ICTP)的变化。结果:在VAS评分、ADL评分和骨代谢改善的基础上,补肾活血汤组VAS评分和血清ICTP,IL-6含量均低于对照组,差异有统计学意义(P<0.01),ADL评分和血清BGP,PINP含量高于对照组,差异有统计学意义(P<0.01),且补肾活血汤组疗效在治疗6个月时较治疗3个月的更加显著,差异有统计学意义(P<0.01)。对比治疗前、治疗6个月两组骨密度的变化,补肾活血汤组骨密度高于对照组,差异有统计学意义(P<0.01)。结论:补肾活血汤能有效缓解OVCF术后患者疼痛,提高日常生活能力,促进骨形成,减少骨吸收,增加骨密度,可能降低OVCF术后患者再发骨折的风险。
Abstract:
To observe the effect of Bushenhuoxue decoction in improving pain and serum bone metabolism of osteoporosis vertebral compression fracture(OVCF)patients after percutaneous kyphoplasty(PKP)surgery.Methods:70 OVCF patients after PKP surgery were randomly divided into an observation group and control group by random number table method.The patients in the control group received calcium carbonate D3 tablets and calcitriol capsules alone in 6 consecutive months,while the patients in the observation group received Bushenhuoxue decoction in addition to calcium carbonate D3 tablets and calcitriol capsules in 6 consecutive months.Visual analogue scale(VAS)score,assessment of activities of daily living(ADL),BMD and serum bone metabolism indicators(IL-6,BGP,PINP,ICTP)were documented to observe the improvement of the treatment of Bushenhuoxue decoction.Results:Based on improvements in VAS score,ADL score and bone metabolism,the VAS and the levels of serum ICTP,IL-6 in the Bushenhuoxue decoction group were lower than those in the control group(P<0.01).The serum BGP and PINP levels in the Bushenhuoxue decoction group were higher than those in the control group(P<0.01).The curative effect in the 6 months of Bushenhuoxue decoction group was more significant than that in the 3 months(P<0.01).For the changement of BMD before treatment and 6 months after treatment,BMD in Bushen Huoxue Decoction group was significant higher than that in control group(P< 0.01).Conclusion:Bushenhuoxue decoction can effectively relieve the pain of patients after OVCF operation,improve their daily life ability,improve bone metabolism,promote bone formation,reduce bone absorption,and increase bone density,which may reduce the risk of recurrent fracture in patients after OVCF operation.

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备注/Memo

备注/Memo:
基金项目:福建中医药大学科研平台开放课题(X2017001-平台)
更新日期/Last Update: 2021-03-15