[1]叶超 陈婧 刘向春 亓建 宗晨钟 王建军 魏峰 唐开强 王庆甫.不同证候膝骨关节炎患者证候程度评分与关节液炎性指标的典型相关分析[J].中国中医骨伤科杂志,2021,29(03):17-20.
　YE Chao CHEN Jing LIU Xiangchun QI Jian ZONG Chenzhong WANG Jianjun WEI Feng TANG Kaiqiang WANG Qingfu.Canonical Correlation Analysis between Syndrome Degree and Inflammatory Index of Synovial Fluid in Patients with Knee Osteoarthritis of Different Syndromes[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2021,29(03):17-20.
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不同证候膝骨关节炎患者证候程度评分与关节液炎性指标的典型相关分析()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第29卷
期数:
2021年03期
页码:
17-20
栏目:
临床研究
出版日期:
2021-03-15

文章信息/Info

Title:
Canonical Correlation Analysis between Syndrome Degree and Inflammatory Index of Synovial Fluid in Patients with Knee Osteoarthritis of Different Syndromes
文章编号:
1005-0205(2021)03-0017-04
作者:
叶超 陈婧 刘向春 亓建 宗晨钟 王建军 魏峰 唐开强 王庆甫
1北京中医药大学(北京,100029)2北京中医药大学东直门医院3北京中医药大学第三附属医院△通信作者 E-mail:qingpu-wang@sohu.com*北京中医药大学以研究生同等学力申请博士学位在职人员
Author(s):
YE Chao CHEN Jing LIU Xiangchun QI Jian ZONG Chenzhong WANG Jianjun WEI Feng TANG Kaiqiang WANG Qingfu
1Beijing University of Chinese Medicine,Beijing 100029,China; 2Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China; 3Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China.
关键词:
膝骨关节炎;  证候;  金属蛋白酶组织抑制因子-1;  基质金属蛋白酶-9;  典型相关分析
Keywords:
knee osteoarthritis;  syndromes;  matrix metalloproteinases-1;  tissue inhibitor of metalloproteinases-9;  canonical correlation analysis
分类号:
R684.3
文献标志码:
A
摘要:
目的:探讨肝肾亏虚证和痰瘀互结证膝骨关节炎患者证候程度评分与关节液TIMP-1及MMP-9炎性指标的典型相关性。方法:采用流行病学横断面调查的方法,测定53例肝肾亏虚证和痰瘀互结证膝骨关节炎患者关节液TIMP-1及MMP-9浓度水平,应用Kellgren-Lawrence(K-L)分级标准量化X线影像学分级,应用中医证候量表通过评分量化证候严重程度,对证候程度评分与关节液炎性指标TIMP-1及MMP-9进行典型相关分析。结果:膝骨关节炎肝肾亏虚证和痰瘀互结证患者在K-L分级比较上差异无统计学意义(P>0.05)。膝骨关节炎患者关节液中TIMP-1浓度水平与中医证候评分之间具有典型相关性(R=0.516)。膝骨关节炎痰瘀互结证患者中医证候评分和炎性指标水平间具有典型相关性(R=0.523)。结论:膝骨关节炎患者关节液中TIMP-1浓度水平能更敏感反映中医证候程度,膝骨关节炎痰瘀互结证患者中医证候严重程度与炎性指标水平的关系密切。炎性指标与证候程度评分的典型相关性为中医药防治膝骨关节炎提供了依据。
Abstract:
To explore the canonical correlation analysis between syndrome degree score and inflammatory markers of joint fluid TIMP-1 and MMP-9 in patients with knee osteoarthritis of liver and kidney deficiency syndrome and phlegm and blood stasis syndrome.Methods:Epidemiological cross-sectional survey was used to measure the concentrations of TIMP-1 and MMP-9 in the synovial fluid of 53 patients with knee osteoarthritis of liver and kidney deficiency syndrome and phlegm and blood stasis syndrome.The Kellgren-Lawrence(K-L)classification standard was used to quantify the X-ray image classification,and the TCM(traditional Chinese medicine)syndrome scale was used to quantify the syndrome degree.The canonical correlation analysis was made between the syndrome degree score and the inflammatory indexes TIMP-1 and MMP-9.Results:There was no statistically significant difference in K-L classification standard between patients with knee osteoarthritis of liver and kidney deficiency syndrome and phlegm and blood stasis syndrome(P>0.05).There was a canonical correlation analysis between the concentration of TIMP-1 in the joint fluid and the TCM syndrome score in patients with knee osteoarthritis(R=0.516). There was a canonical correlation analysis between TCM syndrome score and inflammatory index in patients with knee osteoarthritis of phlegm and blood stasis syndrome(R=0.523).Conclusion:In patients with knee osteoarthritis,the concentration level of TIMP-1 in the joint fluid can more sensitively reflect the degree of TCM syndrome.There is a close relationship between the severity of TCM syndrome and the level of inflammatory indexes in patients with knee osteoarthritis of phlegm and blood stasis syndrome.The canonical correlation analysis between inflammatory index and syndrome degree score provides the basis for TCM prevention and treatment of knee osteoarthritis.

参考文献/References:

[1] 寇龙威,郭艳幸,郭珈宜.中医药治疗膝骨关节炎的研究进展[J].中医药通报,2019,18(6):71-73.
[2] 程环宇,李斯明,孟庆奇,等.骨性关节炎的发病机制与炎症反应的关系[J].中外医学研究,2020,18(6):185-188.
[3] 李怡良,项南,谢飞,等.麝香乌龙丸联合双醋瑞因胶囊治疗风寒湿痹型膝骨关节炎疗效及对患者血清白细胞介素6、基质金属蛋白酶1、基质金属蛋白酶3及金属蛋白酶组织抑制剂1水平的影响[J].河北中医,2020,42(2):225-229.
[4] 中华医学会骨科学分会关节外科学组.骨关节炎诊疗指南(2018年版)[J].中华骨科杂志,2018,38(12):705-715.
[5] 国家中医药管理局医政司.22个专业95个病种中医诊疗方案[G].北京:国家中医药管理局医政司,2010.
[6] 国家食品药品监督管理局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:351.
[7] 颜飞华,韩素英,徐志勇,等.胫骨高位截骨术联合富血小板血浆治疗膝骨关节炎70例[J].中国中医骨伤科杂志,2020,28(6):52-55.
[8] 熊应宗,朱俊琛,王超,等.针刀联合塞来昔布治疗膝骨关节炎的临床疗效观察[J].中国中医骨伤科杂志,2020,28(2):19-23.
[9] FARR J,MILLER L E,BLOCK J E,et al.Quality of life in patients with knee osteoarthritis:a commentary on nonsurgical and surgical treatments[J].The Open Orthopaedics Journal,2013,7(1):619-623.
[10] JESUS C,JESUS I,AGIUS M.Treatment of depression in patients with osteoarthritis:the importance of an early diagnosis and the role of Duloxetine[J].Psychiatria Danubina,2016,28(Suppl-1):149-153.
[11] 黄聪琳,李晓东,谢兴文,等.膝骨关节炎生物标记物研究进展[J].中国中医骨伤科杂志,2019,27(4):81-84.
[12] 钟传棋,杨功旭,戴政文,等.健骨方对早中期膝骨关节炎MMP-13、TIMP1及IL-1β的影响[J].中国中医基础医学杂志,2018,24(12):1727-1729.
[13] 李光,郭启发,黄宁庆,等.膝关节炎软骨基质金属蛋白酶2、基质金属蛋白酶9表达与MRI表现的相关性[J].中国组织工程研究,2016,20(37):5518-5523.
[14] 刘刚,周海宇.川芎嗪注射液灌洗联合玻璃酸钠注射对退行性膝骨关节炎患者关节液中SDF-1、MMPs水平的影响[J].临床医学研究与实践,2018,3(31):48-49.
[15] 杨荣,李跃红,张浩,等.血清MMP-9、TNF-表达水平与膝骨关节炎严重程度及骨密度的相关性研究[J].现代实用医学,2019,31(8):1048-1050.
[16] 赵颖林,裴瑞霞,王茜,等.地黄骨痛康胶囊治疗肝肾亏虚型膝骨关节炎的临床研究[J].中国中医骨伤科杂志,2019,27(7):20-22.
[17] 孙振球.医学统计学[M].3版.北京:人民卫生出版社,2013:375.
[18] 李蒙,张培彤,郭秀伟.中医证候分级量化诊断标准的研究进展[J].中华中医药杂志,2017,32(8):3641-3643.
[19] 马骁,阎小萍,于辉,等.骨关节炎中医证候量化标准积分用于膝骨关节炎的研究[J].中日友好医院学报,2017,31(3):145-148.
[20] SUN Y,WANG C D,GONG C Z.Repairing effects of glucosamine sulfate in combination with etoricoxib on articular cartilages of patients with knee osteoarthritis?[J].J Orthop Surg Res,2020,15(1):150.
[21] 李惠琴,丁韶龙,齐笛.HMGB1、TNF-α、MMP-9及S100A12在骨性膝关节炎中的变化及其意义[J].实验与检验医学,2020,38(2):280-282.
[22] 冀海军,张永红.阳和汤含药血清对膝骨性关节炎兔膝软骨MMP-1、MMP-3和TIMP-1表达的影响[J].四川中医,2020,38(3):72-76.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目( 81874475)中央高校基本科研业务费专项基金( 2018-JYBZZ-JS091)北京中医药大学新奥奖励基金(2018-XAJLJJ-017)
更新日期/Last Update: 2021-03-15