[1]白宏江 葛鹏斌 韩龙 刘鑫 陈颖璞 郭浩△.补肾通络方治疗肝肾亏虚兼寒湿阻痹型膝关节骨性关节炎的临床疗效分析[J].中国中医骨伤科杂志,2020,28(10):20-24.
　BAI Hongjiang GE Pengbin HAN Long LIU Xin CHEN Yingpu GUO Hao.Clinical Analysis of Bushen Tongluo Decoction in TreatingKnee J oint Osteoarthritis with Liver and Kidney Deficiency and Cold and Dampness Obstruction[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2020,28(10):20-24.
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补肾通络方治疗肝肾亏虚兼寒湿阻痹型膝关节骨性关节炎的临床疗效分析()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第28卷
期数:
2020年10期
页码:
20-24
栏目:
临床研究
出版日期:
2020-10-10

文章信息/Info

Title:
Clinical Analysis of Bushen Tongluo Decoction in TreatingKnee J oint Osteoarthritis with Liver and Kidney Deficiency and Cold and Dampness Obstruction
文章编号:
1005-0205(2020)10-0020-05
作者:
白宏江1; 2 葛鹏斌1; 2 韩龙1; 2 刘鑫2 陈颖璞2 郭浩2△
Author(s):
BAI Hongjiang1; 2 GE Pengbin1; 2 HAN Long1; 2 LIU Xin2 CHEN Yingpu2 GUO Hao2△
1Gaoling District Hospital of Traditional Chinese Medicine,Xi'an 710200,China; 2Honghui Hospital Affiliated to Xi'an Jiaotong University,Xi'an 710000,China.
关键词:
骨关节炎;  肝肾亏虚;  寒湿;  补肾通络方
Keywords:
osteoarthritis;  deficiency of liver and kidney;  cold and dampness;  Bushen Tongluo decoction
分类号:
R684.3
文献标志码:
A
摘要:
目的:采用双盲对照随机研究观察补肾通络方对肝肾亏虚兼寒湿阻痹型膝关节骨性关节炎(KOA)患者的临床疗效。方法:收集2018年1月至2019 年12月收治的100例肝肾亏虚兼寒湿阻痹型KOA 患者作为研究对象,按照随机数字表法将病例随机分为治疗组与对照组各50例,治疗组口服中药复方补肾通络方治疗,对照组口服塞来昔布胶囊治疗,以5周为1个疗程,两组患者年龄、性别、病程及 Kellgren-Lawrence(K-L)分级比较,差异均无统计学意义(P>0.05)。分别记录治疗前及治疗后1,3,5 周膝关节活动度、疼痛视觉模拟评分(VAS)、Lequesne 指数评分、WOMAC指数评分以及中医临床表现,判定临床疗效。结果:治疗前两组间膝关节活动度、VAS 评分、Lequesne 指数评分及WOMAC 评分比较,差异均无统计学意义(P>0.05)。两组治疗1,3,5 周后,膝关节活动度、 VAS 评分、Lequesne指数评分及WOMAC 评分与治疗前比较均有改善,但治疗组优于对照组,组间对比差异有统计学意义(P<0.05)。治疗组总有效率为 95.83%,对照组总有效率为79.59%,两组间差异有统计学意义(P<0.05)。结论:补肾通络方治疗肝肾亏虚兼寒湿阻痹型膝关节骨性关节炎,能够提高活动度,改善膝关节功能,缓解疼痛。
Abstract:
To observe the clinical effect of Bushen Tongluo decoction on patient with liver and kidney deficiency and cold dampness obstruction type of knee joint osteoarthritis by double-blind randomized controlled study.Methods:From January 2018 to December 2019,100 cases of KOA patients with deficiency of liver and kidney and obstruction of cold and dampness were collected from Honghui Hospital Affiliated to Xi'an Jiaotong University.The patients were randomly divided into treatment group(50 cases)and control group(50 cases).The treatment group was treated with traditional Chinese medicine compound Bushen Tongluo decoction,while the control group was treated with celecoxib capsule.The treatment period was 5 weeks.There was no significant difference in age,gender,course of disease and Kellgren Lawrence(K-L)classification between the two groups(P>0.05).Before and 1,3,5 weeks after treatment,knee joint activity,pain visual analogue score(VAS),Lequesne index score,WOMAC index score and clinical performance of traditional Chinese medicine were recorded to determine the clinical efficacy.Results:There was no significant difference in knee joint activity,VAS score,Lequesne index score and WOMAC index score between the two groups before treatment(P>0.05).After 1,3 and 5 weeks of treatment,the knee joint activity,VAS score,Lequesne index score and WOMAC index score of the two groups were improved compared with those before treatment,but the treatment group was better than the control group,and the difference between the two groups was statistically significant(P<0.05).The total effective rate was 95.83% in the treatment group and 79.59% in the control group.The difference between the two groups was statistically significant(P<0.05).Conclusion:Bushen Tongluo decoction can improve the activity and the function of knee joint,and relieve the painin treating the osteoarthritis of the knee joint with liver and kidney deficiency and cold dampness obstruction type.

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备注/Memo

备注/Memo:
(收稿日期:2020-04-06)基金项目:陕西省长安郭氏骨伤学术流派工作室建设项目 (陕中医药发〔2018〕40) 1西安市高陵区中医院(西安,710200) 2西安交通大学附属红会医院 △通信作者 E-mail:luchao0925@163.com
更新日期/Last Update: 2020-10-10