[1]邬波△ 柳椰 马旭 吴铁伦 杜明昌 谭成波.壮骨片治疗肝肾亏虚型膝关节骨性关节炎的临床研究[J].中国中医骨伤科杂志,2019,27(10):35-38.
　WU Bo LIU Ye MA Xu WU Tielun DU Mingchang TAN Chengbo.The Clinical Study on the Effects of Zhuanggu Tablets on the Treatment of Liver Kidney Deficiency Syndrome of Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2019,27(10):35-38.
点击复制

壮骨片治疗肝肾亏虚型膝关节骨性关节炎的临床研究()
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第27卷
期数:
2019年10期
页码:
35-38
栏目:
临床研究
出版日期:
2019-10-10

文章信息/Info

Title:
The Clinical Study on the Effects of Zhuanggu Tablets on the Treatment of Liver Kidney Deficiency Syndrome of Knee Osteoarthritis
文章编号:
1005-0205(2019)10-0035-04
作者:
邬波1△ 柳椰1 马旭1 吴铁伦2 杜明昌1 谭成波1
1沈阳市骨科医院关节外科(沈阳,110044) 2沈阳市骨科医院病理科
Author(s):
WU Bo1△ LIU Ye1 MA Xu1 WU Tielun2 DU Mingchang1 TAN Chengbo1
1Department of Joint Surgery of Shenyang Orthopaedic Hospital,Shenyang 110044,China; 2Department of Pathology of Shenyang Orthopaedic Hospital,Shenyang 110044,China.
关键词:
膝关节骨性关节炎;  壮骨片;  临床疗效;  肝肾亏虚型;  炎性反应
Keywords:
knee osteoarthritis;  Zhuanggu tablets;  clinical efficacy;  liver kidney deficiency syndrome;  inflammatory response
分类号:
R684.3
文献标志码:
A
摘要:
目的:观察壮骨片治疗膝关节骨性关节炎的有效性和安全性。方法:选取膝关节骨性关节炎患者60例,采用随机数字表法随机分为2组,壮骨片组和双氯芬酸钠组各30例。壮骨片组每日给药2次,每次4片; 双氯芬酸钠组每日给药2次,每次50 mg.治疗4周后,采用WOMAC评分评定患者的临床疗效,并测定血清及关节液的炎性水平。结果:壮骨片和双氯芬酸钠治疗KOA效果明显。治疗前两组患者血清炎性因子指标和关节滑膜液炎性细胞数差异无统计学意义(P>0.05)。治疗后壮骨片组血清中炎性因子的IL-1,IL-6和TNF-α水平较双氯芬酸钠组略低,但差异无统计学意义(P>0.05)。治疗后壮骨片组与双氯芬酸钠组相比,关节液中中性粒细胞计数稍减少,但差异无统计学意义(P>0.05)。结论:口服壮骨片可有效治疗肝肾亏虚型膝关节骨性关节炎,明显降低炎症因子表达。
Abstract:
Objective:The aim of this study is to investigate the effect of Zhuanggu tablets on inflammatory response of liver kidney deficiency syndrome of knee osteoarthritis.Methods:Patients who were diagnosed with liver kidney deficiency syndrome of knee osteoarthritis in Shenyang orthooedic hospital were selected and divided into two groups by random number table,Zhuanggu group accepted oral Zhuanggu tablet four tablets per time(twice one day for 4 weeks),diclofenac sodium group accepted oral 50 mg diclofenac sodium(twice one day for 4 weeks).Clinical efficacy was evaluated by WOMAC score,serum inflammatory cytokines and the number of inflammatory cells in synovial fluid were recorded for all groups.Results:There was no statistically significant difference of serum inflammatory cytokines and the number inflammatory cells in synovial fluid among the three groups before treatment.After treatment,The index of serum inflammatory factors(IL-1,IL-6 and TNF-α)in Zhuanggu group was a little lower than in diclofenac sodium group and the difference was not statistically significant(P>0.05).The number of neutrophil in Zhuanggu group was also a little lower than that in diclofenac sodium group,without statistically significant differences(P>0.05).Conclusion:Oral Zhuanggu tablets can suppress the local inflammatory response in patients with liver kidney deficiency syndrome knee osteoarthritis.

参考文献/References:

[1] 邬波,柳椰,马旭,等.不同中药制剂治疗骨质疏松的临床观察[J].中华中医药学刊,2016,34(11):2567-2569. [2] 邬波,柳椰,马旭,等.骨髓间充质干细胞体外分化过程中复方接骨片和壮骨片含药血清的作用[J].中国组织工程研究,2017,21(33):5262-5267. [3] 王国栋,王学超,刘赟,等.温经止痛膏治疗膝关节骨性关节炎的临床研究[J].中国中医骨伤科杂志,2014,22(1):20-22. [4] YOSHIMURA N,MURAKI S,NAKAMURA K,et al.Epidemiology of the locomotive syndrome:the research on osteoarthritis/osteoporosis against disability study 2005-2015[J].Modern Rheumatology,2016,27(1):1-7. [5] PHINYOMARK A,OSIS S T,HETTINGA B A,et al.Gender differences in gait kinematics for patients with knee osteoarthritis[J].BMC Musculoskeletal Disorders,2016,17(1):157. [6] PEREIRA D,SEVERO M,RAMOS E,et al.Potential role of age,sex,body mass index and pain to identify patients with knee osteoarthritis[J].Int J Rheum Dis,2017,20(2):190-198. [7] VAN ROSSOM S,WESSELING M,SMITH C R,et al.The influence of knee joint geometry and alignment on the tibiofemoral load distribution:a computational study[J].Knee,2019,18:30525-30528. [8] NEOGI T,GUERMAZI A,ROEMER F,et al.Association of joint inflammation with pain sensitization in knee osteoarthritis:the multicenter osteoarthritis study[J].Arthritis & Rheumatology,2016,68(3):654-661. [9] NGUYEN C,MARIE-MARTINE L,POIRAUDEAU S,et al.Rehabilitation(exercise and strength training)and osteoarthritis:a critical narrative review[J].Annals of Physical and Rehabilitation Medicine,2016,59(3):190-195. [10] 戴政文,杨功旭,邓小川.健骨汤治疗早中期膝骨性关节炎的临床研究[J].中国中医骨伤科杂志,2015,23(3):26-28. [11] 陈健荣,包杭生,卢国良,等.独活寄生汤对膝关节骨性关节炎患者关节液细胞因子水平影响的临床研究——附40例临床资料[J].江苏中医药,2018,50(11):51-53. [12] 陈海霞,张开伟,马文娟,等.补肾活血汤干预骨质疏松并骨关节炎模型兔软骨多种细胞因子mRNA的表达[J].中国组织工程研究,2018,22(32):5123-5132. [13] 范华雨,张向东.中药外用治疗膝骨性关节炎机制的研究进展[J].中国中医骨伤科杂志,2018,26(10):87-89. [14] 邬波,马旭,柳椰,等.不同中药制剂治疗骨折临床观察[J].辽宁中医药大学学报,2014,16(6):5-7. [15] LOESER R F,COLLINS J A,DIEKMAN B O.Ageing and the pathogenesis of osteoarthritis[J].Nature Reviews Rheumatology,2016,12(7):412-420. [16] LI Z M,LI M.Improvement in orthopedic outcome score and reduction in IL-1β,CXCL13,and TNF-α in synovial fluid of osteoarthritis patients following arthroscopic knee surgery[J].Genet Mol Res,2017,16(3).doi:10.4238lgmr126039487. [17] DAS GUPTA E,NG W R,WONG S F,et al.Correlation of serum cartilage oligomeric matrix protein(COMP)and interleukin-16(IL-16)levels with disease severity in primary knee osteoarthritis:a pilot study in a Malaysian population[J].PLoS One,2017,12(9):e0184802. [18] MIN S,WANG C,LU W,et al.Serum levels of the bone turnover markers dickkopf-1,osteoprotegerin,and TNF-α in knee osteoarthritis patients[J].Clinical Rheumatology,2017,36(10):2351-2358.

备注/Memo

备注/Memo:
△通信作者 E-mail:wabc967@126.com
更新日期/Last Update: 2019-10-10