[1]李鑫海 李萍△ 曹义 彭全成.桂枝芍药知母汤为主方治疗痛风的Meta分析[J].中国中医骨伤科杂志,2019,27(02):24-28.
　LI Xinhai LI Ping CAO Yi PENG Quancheng.The Clinical Efficacy of Guizhi Shaoyao Zhimu Tang as MainPrescription in Comparison with Western Medicine in theTreatment of Gout:A Meta Analysis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2019,27(02):24-28.
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桂枝芍药知母汤为主方治疗痛风的Meta分析()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第27卷
期数:
2019年02期
页码:
24-28
栏目:
文献研究
出版日期:
2019-02-15

文章信息/Info

Title:
The Clinical Efficacy of Guizhi Shaoyao Zhimu Tang as MainPrescription in Comparison with Western Medicine in theTreatment of Gout:A Meta Analysis
文章编号:
1005-0205(2019)02-0024-05
作者:
李鑫海1 李萍1△ 曹义1 彭全成1
1湖北汉川市人民医院(湖北 汉川,431600)
Author(s):
LI Xinhai1 LI Ping1△ CAO Yi1 PENG Quancheng1
1Department of Rehabilitation Medicine,Hanchuan People’s Hospital, Hanchuan,431600,Hubei China.
关键词:
桂枝芍药知母汤;  痛风性关节炎;  随机对照试验;  统计分析
Keywords:
Guizhi Shaoyao Zhimu Tang;  gout;  randomized controlled trial;  Meta analysis
分类号:
R589.7
文献标志码:
A
摘要:
系统评价桂枝芍药知母汤为主方治疗痛风的疗效和安全性。方法:计算机检索CNKI,万方数据库、VIP数据库、PubMed数据库,收集单用桂枝芍药知母汤为主方治疗痛风(观察组)对比单用西药(对照组)治疗痛风临床疗效(总有效率、显效率、UA,ESR,CRP)和安全性的临床随机对照试验(RCT)结果。用改良Jadad量表评价纳入研究的方法学质量,并提取有效数据,采用RevMan5.3软件进行Meta分析。结果:共纳入9项RCTs,合计777例患者。Meta分析结果显示:桂枝芍药知母汤为主方治疗痛风在总有效率、显效率及降低UA水平方面,疗效较西药有一定优势,差异有统计学意义(P<0.05); 但在降低ESR和CRP方面,桂枝芍药知母汤为主方较西药无明显优势,差异无统计学意义(P>0.05); 桂枝芍药知母汤为主方治疗痛风的不良反应发生率较西药低,差异有统计学意义(P<0.05)。结论:桂枝芍药知母汤为主方治疗痛风性关节炎较西药有一定优势,且不良反应发生率较低,适合临床推广应用。
Abstract:
To systematically evaluate the efficacy and safety of Guizhi Shaoyao Zhimu Tang as the main prescription in the treatment of gout.Methods: CNKI, Wanfang database, VIP database, PubMed database were searched by computer, randomized controlled trials(RCTs)of Guizhi Shaoyao Zhimu Tang as the main prescription for gout compared about efficacy(total response rate,apparent rate,UA, ESR, CRP)with western medicine alone(control group).The improved Jadad scale was used to evaluate the methodological quality of the study and to extract effective data,and the RevMan 5.3 software was used to analyze the data by Meta analysis. Results: A total of 9 RCTs were included,involving 777 patients. Meta analysis showed that Guizhi Shaoyao Zhimu Tang as the main prescription has a certain advantage in the total effective rate, markedly effective rate and UA level in the treatment of gout, compared with western medicine, the difference is statistically significant(P<0.05). But in reducing ESR and CRP, Guizhi Shaoyao Zhimu Tang as the main prescription has no obvious advantages compared with western medicine, the difference is not statistically significant(P>0.05). The adverse reaction rate of Guizhi Shaoyao Zhimu Tang as the main prescription in treating gout was lower than that of western medicine, and the difference was statistically significant(P<0.05). ConclusionGuizhi Shaoyao Zhimu Tang as the main prescription has a certain advantage over western medicine in the treatment of gout, and the incidence of adverse reaction is low. It is suitable for clinical application.

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备注/Memo

备注/Memo:
1湖北汉川市人民医院(湖北 汉川,431600)△通信作者 E-mail:775803879@qq.com
更新日期/Last Update: 2019-02-15