[1]彭子和 江夏子 唐磊 占仲锋.手法联合玻璃酸钠治疗膝骨性关节炎[J].中国中医骨伤科杂志,2018,26(05):27-30.
　PENG Zihe JIANG Xiazi TANG Lei ZHAN Zhongfeng.Clinical Effect of Manipulation Combined with Sodium Hyaluronate in the Treatment of Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2018,26(05):27-30.
点击复制

手法联合玻璃酸钠治疗膝骨性关节炎()
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第26卷
期数:
2018年05期
页码:
27-30
栏目:
临床研究
出版日期:
2018-05-02

文章信息/Info

Title:
Clinical Effect of Manipulation Combined with Sodium Hyaluronate in the Treatment of Knee Osteoarthritis
文章编号:
1005-0205(2018)05-0027-04
作者:
彭子和1 江夏子1 唐磊1 占仲锋2
1湖北红安县人民医院(湖北 红安,438400) 2湖北红安县中医院
Author(s):
PENG Zihe1 JIANG Xiazi1 TANG Lei1 ZHAN Zhongfeng2
1People's Hospital of Hongan,Hongan 438400,Hubei China; 2Hongan Hospital of Traditional Chinese Medicine,Hongan 438400,Hubei China.
关键词:
骨性关节炎;  中医推拿;  玻璃酸钠;  临床疗效
Keywords:
Keywords: osteoarthritis;  manipulation;  sodium hyaluronate;  clinical efficacy
分类号:
R684.3
文献标志码:
A
摘要:
目的:探讨手法联合关节腔内注射玻璃酸钠治疗膝骨性关节炎的临床效果。方法:选取146例膝关节骨性关节炎患者随机分为3组,A组给予关节腔内注射玻璃酸钠治疗,B组给予手法治疗,C组联合关节腔内注射玻璃酸钠和手法治疗,比较3组疗效及炎症指标。结果 C组治疗后、治疗后6个月VAS评分、Lequesne指数均低于同期A组和B组,差异有统计学意义(P<0.05),同期A组与B组相比较差异均无统计学意义(P>0.05)。C组治疗后WOMAC指数中疼痛、僵硬、日常活动功能及总分、IL-1β、TNF-α、内脂素和瘦素水平均低于同期A组和B组,差异有统计学意义(P<0.05),同期A组与B组相比较差异均无统计学意义(P>0.05)。结论 手法联合关节腔内注射玻璃酸钠具有协同作用,可增加临床疗效,值得推广应用。
Abstract:
Abstract Objective:To investigate the clinical effect of clinical effect of manipulation combined with sodium hyaluronate in the treatment of knee osteoarthritis.Methods:146 knee osteoarthritis patients were randomly divided into 3 groups.Group A received intra-articular injection of sodium hyaluronate,and group B were treated with Chinese medicine massage therapy,and group C received intra-articular injection of sodium hyaluronate combined with traditional Chinese medicine massage,then the curative effect and inflammation index of 3 groups were compared.Results:The VAS score after treatment,the VAS score 6 months after treatment and the Lequesne index in group C were lower than those in group A and group B(P< 0.05).There was no significant difference between the A group and the B group in the same period(P>0.05).The WOMAC scores(pain score,stiffness score,physical function score and total score),and the levels of IL-1β,TNF-α,visfatin and leptin in group C were lower than those in group A and group B(P< 0.05).There was no significant difference between the A group and the B group in the same period(P>0.05).Conclusion:The combination of manipulation and intra-articular injection of sodium hyaluronate has synergistic effect,which can increase the clinical efficacy and is worthy of popularization.

参考文献/References:

[1] 董宝强,张书剑,韩煜,等. 艾灸循经筋阿是穴治疗膝骨性关节炎的临床研究[J].中华中医药学刊,2013,31(9):1839-1840.
[2] 郭军宝.关节腔内注射玻璃酸钠配合肌力训练对膝关节骨性关节炎患者关节功能的影响观察[J].湖南师范大学学报:医学版,2016,13(5):60-62.
[3] 钟晓辉,曾蔚林,胡俊辉,等.手法治疗膝骨性关节炎41例临床研究[J].中外医学研究,2016,14(32):143-145.
[4] 杨春平,温建民,梁朝,等.手法按摩联合补肾活血通络止痛法治疗膝关节骨性关节炎60例[J].陕西中医,2015,36(8):989-991.
[5] 张传东.疏经整复手法调整膝关节肌力平衡治疗膝关节骨性关节炎临床疗效观察[J].亚太传统医药,2016,12(21):109-111.
[6] 连国锋.手法治疗膝关节骨性关节炎临床观察[J].基层医学论坛,2015,19(22):4500-4501.
[7] 高曙光,徐文硕,曾凯斌,等.膝关节骨性关节炎滑液和骨桥蛋白水平与其病变程度的相关性[J].中华骨科杂志,2010,30(7):672-675.
[8] 张董喆.玻璃酸钠结合功能煅炼对膝关节骨性关节炎炎的疗效[J].实用医学杂志,2013,29(18):2994-2994.
[9] 白斌,李燕琴,李曙明,等.丹参对兔骨性关节炎关节软骨白介素-1β、白介素-6和胰岛素样生长因子-Ⅰ表达的影响[J].中国康复医学杂志,2015,30(10):990-994.
[10] 陈巍,李彬,唐中尧,等.膝骨性关节炎炎患者关节滑液IL-1β和TNF-α的表达及临床意义[J].广东医学,2010,31(15):1998-2000.
[11] 李靖扬,加亨,乔为民,等.独活寄生汤联合塞来昔布对膝关节骨性关节炎患者膝关节液IL-1β、TNF-α及MMP-3的影响[J].现代中西医结合杂志,2015,24(25):2780-2782.
[12] 顾海伦,刘亚莉,王维,等.瘦素对IL-1β诱导大鼠骨性关节炎软骨细胞MMP-13 mRNA表达的影响[J].东南大学学报:医学版,2015,34(6):870-875.
[13] 包家鹏.骨性关节炎患者血清和膝关节滑液中内脂素的分布及关节内各不同组织产生内脂素能力的研究[D].杭州:浙江大学医学院,2010.
[14] 江蓉星,熊华,金桂花,等.骨性关节炎的临床治疗研究概况[J].中国中医骨伤科杂志,2003,11(1):57-60.
[15] 麦穗,陈一鑫,陈小莉,等.揉髌手法结合臀部点按手法治疗膝关节骨性关节炎临床研究[J].河北中医,2016,38(6):906-909.
[16] 杜红宾,王奇才.手法治疗膝关节骨性关节炎临床观察[J].中国现代药物应用,2016,10(10):260-261.
[17] 修文明,郭鹏,王冬梅,等.手法推拿治疗膝关节骨性关节炎[J].实用中医内科杂志,2016,30(2):83-84.
[18] 张大富,吕应惠,曲建蕊,等.推拿手法与针灸治疗膝关节骨性关节炎的临床疗效对比研究[J].海南医学,2014,25(5):661-663.
[19] 郑晓斌,林伟容,林远方,等.推拿手法配合温针灸调整膝关节肌力平衡治疗膝骨性关节炎的临床效应分析[J].广州中医药大学学报,2016,33(6):822-827.

更新日期/Last Update: 2018-05-02