[1]朱蜀云△ 马素英.藤黄健骨胶囊联合温针灸治疗原发性骨质疏松症的临床研究[J].中国中医骨伤科杂志,2018,26(01):29-33，38.
　ZHU Shuyun MA Suying.Clinical Study of Tenghuangjiangu Capsule Combined with Warm Acupuncture in Treatment of Primary Osteoporosis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2018,26(01):29-33，38.
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藤黄健骨胶囊联合温针灸治疗原发性骨质疏松症的临床研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第26卷
期数:
2018年01期
页码:
29-33，38
栏目:
临床研究
出版日期:
2018-01-15

文章信息/Info

Title:
Clinical Study of Tenghuangjiangu Capsule Combined with Warm Acupuncture in Treatment of Primary Osteoporosis
文章编号:
1005-0205(2018)01-0029-05
作者:
朱蜀云1△ 马素英1
1北京市鼓楼中医医院骨伤科(北京,100009) △通信作者 E-mail:zhushuyun1968@163.com
Author(s):
ZHU Shuyun1△ MA Suying1
1Department of Orthopaedics and Traumatology, Gulou Hospital of Traditional Chinese Medicine, Beijing 100009, China.
关键词:
藤黄健骨胶囊;  温针灸;  原发性骨质疏松症;  胰岛素样生长因子-1;  临床疗效
Keywords:
Keywords: tenghuangjiangu capsule;  warm acupuncture;  primary osteoporosis;  insulin-like growth factor-1;  clinical efficacy
分类号:
R274.39
文献标志码:
A
摘要:
目的:观察藤黄健骨胶囊联合温针灸对原发性骨质疏松症(POP)患者疗效及血清胰岛素样生长因子-1(IGF-1)和胰岛素样生长因子结合蛋白-3(IGFBP-3)的影响,以期为临床治疗提供理论依据。方法:选取本院收治的POP患者98例作为研究对象,按照随机数字表法分为两组,观察组和对照组各49例。两组均给予健康教育、饮食、运动指导等基础干预,在此基础上对照组给予温针灸治疗,观察组在对照组基础上联合藤黄健骨胶囊治疗。治疗3个疗程后,观察两组中医症候积分、临床疗效、骨密度(BMD)、血清碱性磷酸酶(ALP)、尿钙/肌醉比值(U-Ca/Cr)、尿经脯氨酸/肌醉比值(U-HoP/Cr)以及血清IGF-1和IGFBP-3水平。结果:治疗后对照组中医证候积分为(13.68±3.41)分,观察组为(10.59±3.12)分,治疗后两组中医症候积分显著低于治疗前,差异有统计学意义(P<0.05),且观察组显著低于对照组,差异有统计学意义(P<0.05); 观察组总有效率91.84%显著高于对照组75.51%,差异有统计学意义(P<0.05); 治疗后对照组粗隆间、腰椎、Wards三角区、股骨颈骨密度水平分别为(0.59±0.10)g/cm3,(0.79±0.08)g/cm3,(0.54±0.12)g/cm3和(0.68±0.11)g/cm3,观察组分别为(0.64±0.12)g/cm3,(0.85±0.13)g/cm3,(0.61±0.15)g/cm3及(0.76±0.13)g/cm3,治疗后两组粗隆间、腰椎、Wards三角区、股骨颈BMD水平显著高于治疗前,差异有统计学意义(P<0.05),且观察组显著高于对照组,差异有统计学意义(P<0.05); 治疗后对照组ALP,U-Ca/Cr及U-HoP/Cr分别为(92.57±8.26)mmol/L,(0.46±0.08)μmol/L及(15.28±4.13)μmol/L,观察组分别为(87.46±8.15)mmol/L,(0.41±0.06)μmol/L及(12.56±3.46)μmol/L,治疗后两组ALP,U-Ca/Cr及U-HoP/Cr水平显著低于治疗前,差异有统计学意义(P<0.05),且观察组显著低于对照组,差异有统计学意义(P<0.05); 治疗后对照组IGF-1为(97.43±9.24)ng/mL,观察组为(101.75±10.38)ng/mL; 对照组IGFBP-3为(3.28±1.01)μg/mL,观察组IGFBP-3为(4.36±1.25)μg/mL; 治疗后两组IGF-1及IGFBP-3水平显著高于治疗前,差异有统计学意义(P<0.05),且观察组显著高于对照组,差异有统计学意义(P<0.05); 观察组不良反应发生率4.08%稍低于对照组6.12%,差异无统计学意义(P>0.05)。结论:藤黄健骨胶囊联合温针灸可有效提高POP患者骨密度,改善骨代谢生化水平和血清IGF-1及IGFBP-3水平,提高临床疗效。
Abstract:
Abstract Objective:To observe the influence of Tenghuangjiangu capsule combined with warm acupuncture on curative effect and serum insulin-like growth factor -1(IGF-1)and insulin like growth factor binding protein -3(IGFBP-3)of patients with primary osteoporosis(POP), in order to provide theoretical basis for clinical treatment. Methods: 98 cases with POP treated in our hospital were selected as the study objects, and were divided into two groups according to random number table, 49 cases in each group. All the groups were given basic intervention, such as health education, diet and exercise guidance. On the basis of that, the control group was given warm acupuncture treatment, and the observation group combined with Tenghuangjiangu capsule treatment. After treatment for 3 courses, TCM symptom scores, clinical efficacy, bone mineral density(BMD), serum alkaline phosphatase(ALP), urinary calcium / creatinine ratio(U-Ca/Cr), urinary proline/muscle ratio(U-HoP/Cr)and serum IGF-1 and IGFBP-3 levels were observed in the two groups. Results: After treatment, TCM syndrome scores in the control group was(13.68±3.41)points, and the observation group was(10.59±3.12)points. TCM symptom scores were significantly lower than those before treatment in the two groups(P<0.05), and TCM symptom scores in the observation group were significantly lower than those in the control group(P<0.05). Total effective rate of the observation group was 91.84%, significantly higher than that(75.51%)of the control group(P<0.05). After treatment, bone mineral density levels of intertrochanteric, lumbar, Wards triangle and femur neck in the control group were(0.59±0.10)g/cm3,(0.79±0.08)g/cm3,(0.54±0.12)g/cm3,(0.68±0.11)g/cm3, and those in the observation group(0.64±0.12)g/cm3,(0.85±0.13)g/cm3,(0.61±0.15)g/cm3,(0.76±0.13)g/cm3, respectively. Those indexes after treatment were significantly higher than those before treatment in the two groups(P<0.05), and those in the observation group were significantly higher than those in the control group(P<0.05). After treatment, ALP, U-Ca/Cr and U-HoP/Cr were(92.57±8.26)mmol/L,(0.46±0.08)μmol/L,(15.28±4.13)μmol/L, respectively in the control group, and those were(87.46±8.15)mmol/L,(0.41±0.06)μmol/L,(12.56±3.46)μmol/L, respectively in the observation group. ALP, U-Ca/Cr and U-HoP/Cr levels were significantly lower than those before treatment in the two groups(P<0.05), and those in the observation group were significantly lower than those in the control group(P<0.05). After treatment, IGF-1 was(97.43±9.24)ng/mL in the control group, and that was(101.75±10.38)ng/mL in the observation group. IGFBP-3 was(3.28±1.01)μg/mL in the control group, and that in the observation group was(4.36±1.25)μg/mL. After treatment, IGF-1 and IGFBP-3 levels were significantly higher than those before treatment in the two groups(P<0.05), and those in the observation group were significantly higher than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 4.08%, slightly lower than that of 6.12% in the control group(P>0.05). Conclusion: Tenghuangjiangu capsule combined with warm acupuncture can effectively improve biochemical level of bone metabolism and serum IGF-1 and IGFBP-3 levels, and improve clinical efficacy.

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备注/Memo

备注/Memo:
基金项目:北京中医药薪火传承“3+3”工程项目 马在山名家研究室
更新日期/Last Update: 2018-01-15