[1]陈潮锋 李悦 直彦亮 姜自伟 石宇雄 梁锦成 刘锋 何德利.大鼠缺血性骨折延迟愈合模型的建立[J].中国中医骨伤科杂志,2017,25(12):1-3.
　CHEN Chaofeng LI Yue ZHI Yanliang JIANG Ziwei SHI Yuxiong LIANG Jincheng LIU Feng HE Deli.Establishment of Delayed Union Fracture with Ischemia Model in Rats[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2017,25(12):1-3.
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大鼠缺血性骨折延迟愈合模型的建立()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第25卷
期数:
2017年12期
页码:
1-3
栏目:
实验研究
出版日期:
2017-12-15

文章信息/Info

Title:
Establishment of Delayed Union Fracture with Ischemia Model in Rats
文章编号:
1005-0205(2017)12-0001-03
作者:
陈潮锋1 李悦2 直彦亮1 姜自伟2 石宇雄1 梁锦成1 刘锋1 何德利1
1广州市番禺区中医院(广州,511400) 2广州中医药大学第一附属医院骨科
Author(s):
CHEN Chaofeng1 LI Yue2 ZHI Yanliang1 JIANG Ziwei2 SHI Yuxiong1 LIANG Jincheng1 LIU Feng1 HE Deli1
1Department of Orthopedics,Panyu Hospital of Traditional Chinese Medicine,Guangzhou 511400,China; 2Department of Orthopedics,the First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405,China.
关键词:
骨折延迟愈合;  模型;  动物;  缺血性
Keywords:
Keywords: delayed union of fracture; model;  animal;  ischemic
分类号:
R-33
文献标志码:
A
摘要:
目的:通过一个新型造模为骨折延迟愈合的研究提供新思路。方法:选雌大鼠24只,随机分为A和B组,每组12只,A组麻醉后结扎股动脉,用冲撞法制作股骨骨折模型; B 组麻醉后用冲撞法制作股骨骨折模型。分别于1,4及8周后观察大体标本、骨痂形态、X线检查确定骨折延迟愈合模型形成情况。结果:大体标本肉眼观察、骨组织形态学检查及放射学检查均显示A组骨缺损区骨愈合较B组慢,A组骨性连接出现较晚,骨端硬化。结论:本实验所建立的动物模型,具有缺血性骨折延迟愈合的病理改变,与缺血性骨折延迟愈合的发生机制相符,符合缺血性骨折延迟愈合模型的要求,故可以认为是一种可靠的实验性缺血性骨折延迟愈合动物模型。
Abstract:
Abstract Objective: In this paper,we aimed to provide a new idea by establishing a new animal model for experimental study of delayed union of fractures.Methods:All 24 female rats were divided into two groups averagely.Group A received femoral artery ligation after an aesthesia to make the model of femur fracture; group B only used Collision method to make the model after an aesthesia.Delayed union of fracture was observed by gross,bone histomorphometry and X-ray examination in 1,4 and 8 weeks respectively after the procedure.Results:The bone healing in the group A was slower than group B,bony joints of group A appeared late and bone end sclerosis was demonstrated by gross,bone histomorphometry and X-ray examination.Conclusion:The pathological changes of the established animal model met the demands of delayed union of fracture with ischemic.It can serve as a reliable experimental model for the study of delayed union of fracture with ischemic.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:广东省中医药局科研项目(20171202)
更新日期/Last Update: 2017-12-08