[1]张强,杨刘柱△,李瑞龙,等.不同剂量氨甲环酸减少初次单侧全髋关节置换术手术失血量的比较[J].中国中医骨伤科杂志,2017,25(05):34-37.
　ZHANG Qiang YANG Liuzhusup> LI Ruilong LUO Jin HUANG Wen FENG Liang'en SU Mou.Comparison of Different Doses of Tranexamic Acid in the Reduction of Perioperative Blood Loss in Primary Unilateral Total Hip Arthroplasty[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2017,25(05):34-37.
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不同剂量氨甲环酸减少初次单侧全髋关节置换术手术失血量的比较()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第25卷
期数:
2017年05期
页码:
34-37
栏目:
临床研究
出版日期:
2017-05-08

文章信息/Info

Title:
Comparison of Different Doses of Tranexamic Acid in the Reduction of Perioperative Blood Loss in Primary Unilateral Total Hip Arthroplasty
文章编号:
1005-0205(2017)05-0034-04
作者:
张强1;  杨刘柱1△;  李瑞龙1;  罗谨1;  黄文1;  冯良恩1;  粟谋1
1.广西贺州市人民医院脊柱骨关节外科(广西 贺州,542899)
△.通信作者 E-mail:czylz2013@sina.com
Author(s):
ZHANG Qiang1 YANG Liuzhu<sup>1△ LI Ruilong1 LUO Jin1 HUANG Wen1 FENG Liang'en1 SU Mou1
1.Department of Spine and Orthopedics Surgery,Hezhou People's Hospital,Hezhou 542899,Guangxi China.
关键词:
氨甲环酸;  髋关节置换术;  手术失血量;  并发症
Keywords:
tranexamic acid;  hip arthroplasty;  perioperative blood loss;  complications
分类号:
R687.4
文献标志码:
A
摘要:
目的:探究不同剂量氨甲环酸(TXA)减少初次单侧全髋关节置换术手术失血量的比较。方法:收集2015年9月至2016年11月在本院行初次单侧全髋关节置换术手术的患者59例,根据术前是否应用TXA及剂量的不同分为对照组、低剂量组和高剂量组。主要研究指标为手术理论失血量(TTBL)和手术显性失血量(TBL)。结果:对照组TTBL明显高于低剂量组和高剂量组,差异有统计学意义(P<0.05),而低剂量组TTBL与高剂量组相比较,其差异无统计学意义(P=0.64)。对照组TBL与低剂量组和高剂量组相比较,其差异有统计学意义(P<0.001),尽管高剂量组TBL低于低剂量组,但两者之间相比,差异无统计学意义(P=0.619)。就输血率相比而言,三组之间的输血率差异无统计学意义(P=0.361)。整个研究期间没有发现并发症。结论:术前1 h应用TXA可以有效减少初次单侧全髋关节置换术手术失血量,应用0.5 g/次/人TXA剂量与1 g/次/人TXA剂量在减少初次单侧全髋关节置换手术失血量方面可能具有相同的作用。
Abstract:
Objective:To compare the efficacy of different doses of tranexamic acid(TXA)in the reduction of perioperative blood loss in primary unilateral total hip arthroplasty.Methods:From September 2015 to November 2016,59 patients with primary unilateral total hip arthroplasty were enrolled in our hospital.According to whether the preoperative application of TXA and different doses of TXA,the patients were divided into the control group,low-dose group and high-dose group.The surgical total blood loss(TTBL)and surgical dominant blood loss(TBL)were the main research indicators.Results:The TTBL of the control group was significantly higher than that of the low dose group and the high dose group(P<0.05),but there was no significant difference between the low dose group and the high dose group(P=0.64).There was statistically significant difference when the TBL of control group compared with low and high dose groups(P<0.001).Although the TBL of high-dose group was lower than that of low-dose group,there the was no statistically significant difference when compared to each other(P=0.619).In terms of blood transfusion rate,there was no statistically significant differences between the three groups(P=0.361).No complications were found throughout the study period.Conclusion:TXA can reduce perioperative blood loss in primary unilateral total hip arthroplasty effectively,when it was given to patients 1 hour before operation.Application of 0.5 g/person/time and 1 g/person/time TXA dosage may have the same effect on reducing perioperative blood loss in primary unilateral total hip arthroplasty.

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更新日期/Last Update: 2017-05-01