[1]仰嘉轩,郭海玲,毛敦,等.骨质疏松症患者腰椎有限元模型的建立与骨强度分析[J].中国中医骨伤科杂志,2017,25(05):13-17.
　YANG Jiaxuan GUO Hailing MAO Dun ZHAO Yongfang.Establishment of Finite Element Model of Lumbar Spine in Patients with Osteoporosis and Analysis of Bone Strength[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2017,25(05):13-17.
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骨质疏松症患者腰椎有限元模型的建立与骨强度分析()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第25卷
期数:
2017年05期
页码:
13-17
栏目:
临床研究
出版日期:
2017-05-08

文章信息/Info

Title:
Establishment of Finite Element Model of Lumbar Spine in Patients with Osteoporosis and Analysis of Bone Strength
文章编号:
1005-0205(2017)05-0013-05
作者:
仰嘉轩1;  郭海玲2;  毛敦1;  赵咏芳2△
1.江苏苏州市苏州高新区人民医院(江苏 苏州,215129)
2.上海中医药大学附属曙光医院
△.通信作者 E-mail:zhao_dingding@126.com
Author(s):
YANG Jiaxuan1 GUO Hailing2 MAO Dun1 ZHAO Yongfang2△
1.Suzhou New District People's Hospital,Suzhou 215129,Jiangsu China;
2.Shuguang Hospital,Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China.
关键词:
有限元分析;  骨质疏松症;  腰椎;  骨强度;  生物力学
Keywords:
finite element analysis;  osteoporosis;  lumbar;  bone strength;  biomechanics
分类号:
R68
文献标志码:
A
摘要:
目的:基于骨质疏松症患者CT图像个体化精准建立单个腰椎(L2)的有限元模型,并对模型进行骨强度分析。方法:采用交互式医学图像控制系统MIMICS软件对患者的CT图片进行预处理后,导入大型通用有限元软件ANSYS中个体化精准建立L2有限元模型。通过模拟正常站立、一般活动和突然跌倒时,分别在上终板施加0.3,1.0,4.0 MPa轴向载荷,计算最大应变数值以及von Mises应变值高于5 000 με骨体积占总体积比率。结果:随着载荷逐步加大,位移、应力和应变也分别变大,具有骨折风险的骨体积也明显增加,分别增加0.08%,38.39%,57.80%.结论:本研究建立的有限元模型符合骨质疏松性单个腰椎的临床特点,模拟了其生物力学特性。
Abstract:
Objective:To establish a finite element model of individual lumbar spine(L2)based on individualized precision CT images of osteoporosis patients,and to analyze the bone strength of the model.Methods:The CT images of the patients were pretreated by the MIMICS software of the interactive medical image control system and then introduced into the large-scale general finite element software ANSYS to establish the L2 finite element model accurately.By simulating normal standing,general activity and sudden falling,the axial load of 0.3,1.0,4.0 MPa was applied to the upper endplate respectively,and the ratios of the maximum strain values and the von Mises strain higher than bone volume to total volume of 5 000 με were calculated.Results:As the load gradually increased,the displacement,stress and strain were also increased,and the bone volume with fracture risk increased significantly,with 0.08%,38.39% and 57.80% respectively.Conclusion:The finite element model established in this study is consistent with the clinical characteristics of osteoporotic single lumbar spine,and it simulates the biomechanical properties.

参考文献/References:

[1] Rubin CD.Emerging concepts in osteoporosis and bone strength[J].Curr Med Res Opin,2005,21(7):1049-1056.
[2] 张磊,林松青,杨曾静,等.脊柱胸腰段及其压缩骨折有限元模型的建立及意义[J].中国中医骨伤科杂志,2015,23(2):21-23.
[3] 刘勇,田青,李国庆,等.骨质疏松腰椎三维有限元模型的建立[J].中华实验外科杂志,2013,30(1):161-162.
[4] 蔡康健,王丽珍,姚杰,等.腰椎椎体有限元建模的最优单元尺寸和材料属性分布及建模方法[J].医用生物力学,2016,31(2):135-141.
[5] Rho JY,Hobatho MC,Ashman RB.Relations of mechanical properties to density and CT numbers in human bone[J].Med Eng Phys,1995,17(5):347-355.
[6] Morgan EF,Bayraktar HH,Keaveny TM.Trabecular bone modulus-density relationships depend on anatomic site[J].J Biomech,2003,36(7):897-904.
[7] Mirzaei M,Zeinali A,Razmjoo A,etal.On prediction of the strength levels and failure patterns of human vertebrae using quantitative computed tomography(QCT)-based finite element method[J].J Biomech,2009,42(11):1584-1591.
[8] 费琦,李秋军,杨雍,等.胸腰段骨质疏松性椎体压缩骨折三维有限元模型的建立和应力分析[J].中华医学杂志,2010,90(41):2943-2946.
[9] Bessho M,Ohnishi I,Kaneko M,et al.Prediction of bone strength using a quantitative computed tomography based finite element method[J].Clin Calcium,2011,21(7):1021-1027.
[10] Buckley JM,Loo K,Motherway J.Comparison of quantitative computed tomography-based measures in predicting compressive strength[J].Bone,2007,40(3):767-774.
[11] Sidorenko I,Monetti R,Bauer J,et al.Assessing methods for characterising local and global structural and biomechanical properties of the trabecular bone network[J].Curr Med Chem,2011,18(22):3402-3409.
[12] Kopperdahl DL,Keaveny TM.Yield strain behavior of trabecular bone[J].J Biomech,1998,31(7):601-608.
[13] Homminga J,Weinans H,Gowin W,et a1.Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution[J].Spine,2001,26(14):1555-1561.
[14] 吴胜勇,张美超,李景学,等.骨质疏松老年妇女腰椎有限元分析对骨强度的评价[J].中国骨质疏松杂志,2005,11(3):292-295.
[15] Eswaran SK,Gupta A,Adams MF,et a1.Cortical and trabecular load sharing in the human vertebral body [J].J Bone Miner Res,2006,21(7):307-314.
[16] Roy ME,Rho JY,Tsui TY,et a1.Mechanical and morphological variation of the human lumbar vertebral cortical and trabecular bone[J].J Biomed Mater Res,1999,44(2):191-197.
[17] Liebschner MA,Kopperdahl DL,Rosenberg WS,et al.Finite element modeling of the human thoracolumbar spine[J].Spine,2003,28(6):559-565.
[18] Jones AC,Wilcox RK.Assessment of factors influencing finite element vertebral model predictions[J].Journal of Biomechanical Engineering,2007,129(6):898-903.
[19] 卢昌怀,刘志军,张宏波,等.骨水泥量及分布对椎体成形术后相邻椎体生物力学影响的三维有限元分析[J].中国骨质疏松杂志,2015,21(1):29-33.
[20] Imai K,Ohnishi I,Bessho M,et al.Nonlinear finite element model predicts vertebral bone strength and fracture site[J].Spine,2006,31(16):1789-1794.

备注/Memo

备注/Memo:
基金项目:“中医骨伤科学”国家重点学科(100508)
上海市中医药领军人才建设项目(2012-63-15)
上海领军人才项目(041)
“海派中医流派传承研究基地”(ZYSNXD-CC- HPGC-JD-001)
国家自然科学基金项目(81173621,81473703,81403415)
上海市科委中医引导项目(14401933700)
重大新药创制科技重大专项项目(2015ZX09101021)
上海市中医药事业发展三年行动计划(ZY3-CCCX-3-2008)
上海浦东新区卫生系统重点学科群建设项目 上海市申康慢性病综合防治项目(SHDC12015316)
更新日期/Last Update: 2017-05-01