[1]雷宁波△,彭冉东,邓强,等.依降钙素联合损伤胶囊对骨质疏松性椎体压缩骨折PKP术后早期临床疗效观察[J].中国中医骨伤科杂志,2017,25(05):9-12.
　LEI Ningbo PENG Randong DENG Qiang ZHAO Jun LI Zhongfeng HAN Xianfu LI Junjie.Observation on the Early-term Clinical Efficacy of Calcitonin Combined with Damage Capsule on the Osteoporotic Vertebral Compression Fractures after PKP[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2017,25(05):9-12.
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依降钙素联合损伤胶囊对骨质疏松性椎体压缩骨折PKP术后早期临床疗效观察()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第25卷
期数:
2017年05期
页码:
9-12
栏目:
临床研究
出版日期:
2017-05-08

文章信息/Info

Title:
Observation on the Early-term Clinical Efficacy of Calcitonin Combined with Damage Capsule on the Osteoporotic Vertebral Compression Fractures after PKP
文章编号:
1005-0205(2017)05-0009-04
作者:
雷宁波1△;  彭冉东2;  邓强1;  赵军1;  李中锋1;  韩宪富2;  李军杰2
1.甘肃省中医院(兰州,730050)
2.甘肃中医药大学
△.通信作者 E-mail:1491772672@qq.com
Author(s):
LEI Ningbo1△ PENG Randong2 DENG Qiang1 ZHAO Jun1 LI Zhongfeng1 HAN Xianfu2 LI Junjie2
1.Gansu Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu,China;
2.Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu,China.
关键词:
椎体后凸成形术(PKP);  依降钙素;  损伤胶囊;  绝经后妇女;  骨质疏松性椎体压缩骨折
Keywords:
percutaneous kyphoplasty(PKP);  calcitonin;  damage capsule;  postmenopausal women;  osteoporotic vertebral compression fractures
分类号:
R683.2
文献标志码:
A
摘要:
目的:观察依降钙素联合损伤胶囊对骨质疏松性椎体压缩骨折行经皮球囊扩张椎体后凸成形术(PKP)术后早期临床疗效。方法:将 2013年6月至2015年3月本科收治的骨质疏松性椎体压缩骨折行PKP术的绝经后妇女随机分为两组:观察组(36例)行PKP术后给予依降钙素肌注并配合本院制剂损伤胶囊口服; 对照组(36例)单纯予以依降钙素肌注。对所有患者均进行不少于1年的随访。采用视觉模拟疼痛评分(Visual Analogue Scale,VAS)及Oswestry功能障碍指数(Oswestry Dability Index,ODI)对纳入患者腰背部疼痛、活动功能进行评估; 采用双能X线骨密度仪(DXA)测量腰椎(L2～4)骨密度值(BMD); 行腰/胸椎正侧位检查,观察术后再骨折发生率。定期对患者进行随访,记录相关测量数据。结果:两组患者术后第3天腰背部疼痛及功能障碍均缓解,但对照组术后6个月、末次随访时VAS评分及ODI指数均高于观察组,差异有统计学意义(P<0.05)。末次随访,观察组与对照组骨密度T值分别为(-2.01±0.680)和(-2.24±0.023),差异有统计学意义(P<0.05)。据统计,至末次随访时对照组与观察组术后再骨折分别为共8例和2例,两组术后再骨折总发生率比较差异有统计学意义(χ2=4.181,P<0.05),再骨折发生时间集中在术后(4.5±0.57)个月。结论:骨质疏松性椎体压缩骨折PKP术后给予依降钙素联合损伤胶囊可减轻因骨质疏松进行性加重导致的腰背痛并能有效降低早期再骨折的发生率。
Abstract:
Objective:To observe the early-term clinical efficacy of calcitonin combined with Damage capsule on osteoporotic vertebral compression fractures after percutaneous kyphoplasty(PKP).Methods:From June 2013 to March 2015,the postmenopausal women treated by our department who underwent the PKP of osteoporotic vertebral compression fractures were randomly divided into two groups.The observation group(n=36)was given intravenous calcitonin intramuscular injection combined with our Damage capsule oral,and the control group(n=36)was simply administered with calcitonin intramuscular injection,all patients were followed for at least 1 year.The visual analogue scale(VAS)and oswestry dability index(ODI)were used to evaluate the lower back pain and activity function of patients.The bone mineral density(BMD)of lumbar vertebrae(L2～4)was measured by dual energy X-ray absorptiometry(DXA).The positive and lateral sides of lumbar/thoracic spine were checked to observe the incidence of postoperative secondary fracture.Patients were followed up on a regular basis,and the relevant measurement data was recorded.Results:The lower back pain and dysfunction of the patients in two groups were relieved at 3 days after operation,but the VAS score and ODI index in the control group were higher than that in the observation group at 6 months after operation(P<0.05).At the last follow-up,the T values of the bone mineral density in the observation group and the control group were(-2.01±0.680)and(-2.24±0.023),respectively.The difference was statistically significant(P<0.05).According to statistics,to the last follow-up,the number of occurring the postoperative secondary fracture in the control group and observation group was 8 cases and 2 cases,respectively.The total incidence rate of postoperative secondary fracture in the two groups was statistically significant(χ2=4.181,P<0.05),and the time of occurring secondary fracture was focused on postoperative(4.5±0.57)months.Conclusion:Osteoporotic vertebral compression fractures PKP postoperative administration of calcitonin combined with damage capsules can reduce the lower back pain caused by progressive increasing in osteoporosis and the incidence of early-term secondary fracture effectively.

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备注/Memo

备注/Memo:
基金项目:卫生部医药卫生科技发展研究中心科研基金 (W2014ZT210)
甘肃省中医药管理局科研课题(GZK-2016-49)
国家中医药管理局国家中医临床研究基地业务 建设科研专项课题(JDZX2015039)
更新日期/Last Update: 2017-05-01