[1]陈达 彭力平△ 廖州伟 马笃军.牛膝醇溶液透药联合硫酸氨基葡萄糖治疗膝骨关节炎的临床观察[J].中国中医骨伤科杂志,2016,24(12):29-31,37.
　CHEN Da PENG Liping LIAO Zhouwei MA Dujun.Clinical Observation of Achyranthes Bidentata Alcohol Solution Iontophoresis Combined with Glucosamine Sulfate in the Treatment of Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2016,24(12):29-31,37.
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牛膝醇溶液透药联合硫酸氨基葡萄糖治疗膝骨关节炎的临床观察
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第24卷
期数:
2016年12期
页码:
29-31,37
栏目:
临床研究
出版日期:
2016-12-05

文章信息/Info

Title:
Clinical Observation of Achyranthes Bidentata Alcohol Solution Iontophoresis Combined with Glucosamine Sulfate in the Treatment of Knee Osteoarthritis
作者:
陈达1 彭力平2△ 廖州伟1 马笃军2
Author(s):
CHEN Da1 PENG Liping2△ LIAO Zhouwei1 MA Dujun2
1Shenzhen Clinical Medical College Affiliated to Guangzhou University of Traditional Chinese Medicine,Shenzhen 518033,Guangdong China; 2Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen 518033,Guangdong China.
关键词:
牛膝醇溶液;  透入疗法;  膝骨关节炎;  硫酸氨基葡萄糖;  临床观察
Keywords:
achyranthes bidentata alcohol solution;  lontophoresis;  osteoarthritis;  glucosamine sulfate;  clinical observation
分类号:
R684.3
文献标志码:
A
摘要:
目的:观察牛膝醇溶液透药联合硫酸氨基葡萄糖治疗膝骨关节炎的疗效。方法:将75例膝骨关节炎患者采用随机数字表法随机分为3组,每组25例。A组为治疗组,接受牛膝醇溶液透药及口服硫酸氨基葡萄糖治疗,B,C组为对照组,B组只接受牛膝醇溶液透药治疗,C组只口服硫酸氨基葡萄糖治疗,连续治疗6周,透药为每5 d后休息2 d.观察、比较3组治疗前后视觉模拟系统(VAS)评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC评分)及膝关节肿胀评分。结果:治疗后3组各项临床评分较治疗前均显著好转(P<0.05); 其中3组间的VAS评分差异无统计学意义(P>0.05),而在WOMAC评分、膝关节肿胀评分上A组优于B,C组,且差异有统计学意义(P<0.05),B组和C组间差异无统计学意义(P>0.05)。结论:牛膝醇溶液透药联合口服硫酸氨基葡萄糖,较单用牛膝醇溶液和硫酸氨基葡萄糖,对膝骨关节炎疗效更佳,值得临床推广。
Abstract:
Objective:To observe the clinical effects of achyranthes bidentata alcohol solution iontophoresis combined with glucosamine sulfate in the treatment of knee osteoarthritis.Methods:75 patients with knee osteoarthritis were randomly divided into 3 groups,25 patients in each group.Group A was treated with achyranthes bidentata alcohol solution iontophoresis and oral glucosamine sulfate.Group B and C were control groups,B group was treated only with achyranthes bidentata alcohol solution iontophoresis,and group C only with oral glucosamine sulfate,continuous treatment for 6 weeks,iontophoresis treatment for 5 days every 2 days.Comparison of VAS score,WOMAC score and knee swelling score among 3 groups before and after treatment were performed.Results:After treatment,the clinical scores of the 3 groups were significantly improved compared with those before treatment(P<0.05).There was no significant difference in VAS score among the 3 groups(P>0.05),while in the WOMAC score,knee joint swelling score of A group was better than those of B,C group,and the difference was statistically significant(P<0.05),there was no significant difference between B group and C group(P>0.05).Conclusion:Achyranthes bidentata alcohol solution iontophoresis combined with oral glucosamine sulfate has better effect than achyranthis bidentatae alcohol solution iontophoresis or oral glucosamine sulfate alone for treating knee osteoarthritis,and thus is worthy of clinical promotion.

参考文献/References:

[1] 阳乐,许鹏.促炎细胞因子与骨关节炎[J].中华骨与关节外科杂志,2015,8(5):455-459.
[2] 肖伟,彭力平,林栋栋.牛膝醇溶液透药疗法对膝骨性关节炎的疗效观察[J].中国中医骨伤科杂志,2015,23(8):37-40.
[3] 中华医学会骨科学分会.骨关节炎诊治指南(2007年版)[J].中国临床医生,2008,42(1):28-30.
[4] 胡永成.骨科疾病疗效评价标准[M].北京:人民卫生出版社,2012.
[5] 张新玉,魏丽.骨关节炎发病机理的研究进展[J].河北医学,2016,22(4):666-668.
[6] 包德明.膝关节骨关节炎的治疗进展[J].中医正骨,2014(12):52-55.
[7] 何少斌.中西医结合治疗老年骨关节炎的疗效评价[J].实用临床医药杂志,2014,18(9):169-170.
[8] 郑斌,梅伟,魏成建.中医治疗膝骨关节炎研究进展[J].湖北中医药大学学报,2016,18(2):114-117.
[9] 彭力平,马笃军,林栋栋,等.牛膝醇溶液体内诱导兔骨关节炎模型软骨修复的病理学观察[J].湖南中医杂志,2013,29(2):126-129.
[10] 彭力平,马笃军,裴军宇,等.牛膝醇溶液对急性软骨损伤兔软骨的影响[J].中医杂志,2013,54(17):1504-1506.
[11] Zuo J,Du L,Li M,et al.Transdermal enhancement effect and mechanism of iontophoresis for non-steroidal anti-inflammatory drugs[J].Int J Pharm,2014,466(1-2):76-82.
[12] Rajagopal R,Mallya NB.Comparative evaluation of botulinum toxin versus iontophoresis with topical aluminium chloride hexahydrate in treatment of palmar hyperhidrosis[J].Med J Armed Forces India,2014,70(3):247-252.
[13] 常晓涛,孙珍.氨基葡萄糖治疗骨关节炎的临床近况[J].中国中医骨伤科杂志,2011,19(9):77-80.
[14] 杨旦红,穆怀典,黄俊武.硫酸氨基葡萄糖治疗膝骨关节炎的临床分析[J].中国医药指南,2015,13(22):112-113.

备注/Memo

备注/Memo:
1广州中医药大学第四临床医学院(广东 深圳,518033) 2深圳市中医院 △通信作者 E-mail:plp001@sina.com
更新日期/Last Update: 2016-12-01