[1]夏雪 马陈 沈霖△ 杨艳萍 帅波 吕林.古方青娥丸治疗绝经后骨质疏松症的临床疗效观察[J].中国中医骨伤科杂志,2016,24(07):20-22.
　XIA Xue MA Chen SHEN Lin YANG Yanping SHUAI Bo L Lin.Clinical Research of Ancient Qing'e Pill on the Treatment of Postmenopausal Osteoporosis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2016,24(07):20-22.
点击复制

古方青娥丸治疗绝经后骨质疏松症的临床疗效观察
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第24卷
期数:
2016年07期
页码:
20-22
栏目:
临床研究
出版日期:
2016-07-15

文章信息/Info

Title:
Clinical Research of Ancient Qing'e Pill on the Treatment of Postmenopausal Osteoporosis
文章编号:
1005-0205(2016)07-0020-03
作者:
夏雪1 马陈1 沈霖1△ 杨艳萍1 帅波1 吕林1
1.华中科技大学同济医学院附属协和医院中西医结合科(武汉,430022)
△.通信作者 E-mail:shenlinhb@sina.cn
Author(s):
XIA Xue1 MA Chen1 SHEN Lin1△ YANG Yanping1 SHUAI Bo1 LÜ Lin1
1.Department of Integrated Traditional Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China.
关键词:
古方青娥丸;  绝经后骨质疏松症;  疼痛
Keywords:
ancient Qing'e pill;  postmenopausal osteoporosis;  pain
分类号:
R274.39
文献标志码:
A
摘要:
目的:观察古方青娥丸治疗绝经后骨质疏松症临床疗效,同时初步探讨剂量与有效性、安全性的关系。方法:60例绝经后骨质疏松症患者随机分成3组:A组(大剂量组),B组(正常剂量组),C组(安慰剂组),三组患者均治疗24周,服用钙尔奇D片。对三组患者治疗前后的临床症状、腰背四肢骨痛进行VAS评分,并对骨密度的改善情况进行评估,治疗期间行常规肝肾功能等检查。结果:A组与B组的主要临床症状、腰背四肢骨痛VAS评分治疗后均改善,差异有统计学意义(P值均小于0.01); A组改善优于B组,组间差异有统计学意义(P<0.05),C组治疗后差异无统计学意义(P>0.05); A组和B组治疗后骨密度增加差异有统计学意义(P值均小于0.01),A组增加优于B组,组间差异有统计学意义(P<0.05),C组治疗后差异无统计学意义(P>0.05)。结论:古方青娥丸能改善临床症状,升高骨密度值,用药安全,其疗效与剂量相关。
Abstract:
Objective:To observe the clinical efficacy of ancient Qing'e pill on the treatment of postmenopausal osteoporosis,and to investigate the relationship between the dose and efficacy,the dose and safety.Methods:All 60 patients with postmenopausal osteoporosis were randomly divided into 3 groups:group A(large dose group),group B(normal dose group),and group C(placebo group).They were taking calcium and other treatment for 24 weeks.The clinical symptoms,VAS score of lower back and four limbs pain,and the improvement of the bone mineral density(BMD)were analyzed.The regular examination such as liver and kidney function during the treatment were detected.Results:The main clinical symptoms,VAS score of lower back and four limbs pain,and BMD in group A and B after treatment were significantly improved than baseline(P<0.01), and group A was better than group B(P<0.05),there was no statistically difference in group C after treatment(P>0.05).Conclusion:Ancient Qing'e pill can safely and effectively improve clinical symptoms,and increase BMD.

参考文献/References:

[1] 陈浩,冯飞,朱富强,等.老年骨折患者25-羟基维生素D和甲状旁腺素与骨质疏松程度的相关性[J].中华骨质疏松和骨矿盐疾病杂志,2013,6(1):20-27.
[2] 赵光,沈霖,杨艳萍.青娥丸对绝经后骨质疏松症患者骨密度、血清MMP-2水平及骨代谢指标的影响[J].中西医结合研究,2012,4(3):113-117.
[3] 徐晓娟,沈霖,杨艳萍,等.青娥丸对绝经后骨质疏松症患者骨密度和骨转换标志物的影响[J].中国中医骨伤科杂志,2013,21(6):8-10.
[4] 帅波,沈霖,杨艳萍,等.补肾活血方治疗早期缺血性股骨头坏死患者的临床研究[J].中国中医骨伤科杂志,2013,21(1):11-14.
[5] 张建梅,李瓦里.植物雌激素防治绝经后骨质疏松的研究进展[J].现代药物与临床,2012,27(1):65-69.
[6] Mohamad S,Shuid AN,Mohamed N.The effects of alpha-tocopherol supplementation on fracture healing in a postmenopausal osteoporotic rat model[J].Clinics,2012,67(9):1077-1085.
[7] Takada T,Iba K,Yoshizaki T,et al.Correlation between a bone resorption marker and structural geometry of the proximal femur in osteoporotic women treated with raloxifene[J].J Orthop Surg(Hong Kong),2012,20(2):209-213.
[8] 马芳远,高青房,朱秀华.原发性骨质疏松症临床药物治疗新进展[J].中国老年保健医学.2013,11(1):48-49.
[9] 范鸣.抗骨质疏松症药鲑鱼降钙素长期使用具有致癌风险[J].药学进展,2013,37(4):188-189.
[10] Poole KE,Compston JE.Osteoporosis and its management[J].BMJ,2006,333(7581):1251-1256.
[11] Lata PF,Elliott ME.Patient assessment in the diagnosis,prevention,and treatment of osteoporosis[J].Nutr Clin Pract,2007,22(3):261-275.
[12] 牛煜.青娥丸治疗绝经后骨质疏松症疗效观察[J].深圳中西医结合杂志,2012,22(2):101-102.
[13] 翁泽斌,颜翠萍,张志杰,等.不同炮制品入药的青娥丸含药血清对人成骨细胞增殖、分化及矿化的影响[J].中国实验方剂学杂志,2015,21(6):165-169.
[14] Takeuchi Y.Diabetes mellitus and osteoporosis.Therapeutic strategy for osteoporosis in patients with diabetes mellitus[J].Clinical Calcium,2012,22(9):1410-1415.
[15] Bohm ER,Tufescu TV,Marsh JP.The operative management ofosteoporotic fractures of the knee:to fix or replace[J].J Bone and Joint Surg Br,2012,94(9):1160-1169.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81473492)
更新日期/Last Update: 2016-07-01