[1]佟德民 郭玉海 孙利群 麦国明 黄瑜 朱晓龙 禤翠玲 符路娣 谭滴清.自体垂直悬吊牵引对兔退变椎间盘组织的影响[J].中国中医骨伤科杂志,2015,23(07):1-4.
　TONG Demin GUO Yuhai SUN Liqun MAI Guoming HUANG Yu ZHU Xiaolong XUAN Cuiling FU Ludi TAN Diqing.Histopathological Effects of Gravitational Traction on Degenerative Disc of Rabbit[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2015,23(07):1-4.
点击复制

自体垂直悬吊牵引对兔退变椎间盘组织的影响
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第23卷
期数:
2015年07期
页码:
1-4
栏目:
实验研究
出版日期:
2015-07-15

文章信息/Info

Title:
Histopathological Effects of Gravitational Traction on Degenerative Disc of Rabbit
文章编号:
1005-0205(2015)07-0001-04
作者:
佟德民1 郭玉海2 孙利群1 麦国明1 黄瑜1 朱晓龙1 禤翠玲3 符路娣4 谭滴清4
1.广州医科大学附属第五医院(广州,510700)
2.广东省中医院骨一科
3.广州中医药大学第一附属医院
4.广州中医药大学动物实验中心
Author(s):
TONG Demin1 GUO Yuhai2 SUN Liqun1 MAI Guoming1 HUANG Yu3 ZHU Xiaolong3 XUAN Cuiling4 FU Ludi4 TAN Diqing4
1.Department of Traditional Chinese Medicine, the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700,China;
2.First Department of Orthopaedics, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120,China;
3.The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510400,China;
4.Animal Experimental Center of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405,China.
关键词:
自体垂直悬吊牵引;  退变椎间盘;  病理组织;  兔
Keywords:
gravitational traction;  degenerative disc;  histopathology;  rabbit
分类号:
R-33
文献标志码:
A
摘要:
目的:探讨自体垂直悬吊牵引对新西兰大白兔退变椎间盘病理组织的影响。方法:以16G针刺损伤18只新西兰大白兔腰椎椎体右前侧纤维环制备椎间盘退变模型,随机分为牵引组和对照组。牵引组(n=8)行自体垂直悬吊牵引,每天牵引30 min,连续牵引8周。对照组(n=8)不予治疗,分别于牵引后2、4、6、8周行腰椎侧位X线检查和病理组织学观察。结果:随着牵引时间的延长,牵引组腰椎间隙高度逐渐增加,椎间盘内的含水量及活椎间盘细胞数量增多,纤维环排列日趋规则。结论:自体垂直悬吊牵引可能延缓和抑制椎间盘退变。
Abstract:
Objective: To explore the effect of gravitational traction on histopathological change of degenerative disc of New Zealand white rabbits. Methods: In order to create intervertebral disc degeneration models, the right front side of the annulus fibrous of lumbar vertebrae of rabbits were damaged by 16-gauge needle. After confirming the success of modeling,16 animal models were randomized into 2 groups,8 of which received a routine gravitational traction using a model of our own design,30 min per day, for 8 weeks, while the control group received no treatment. Histopathological observation and lateral spine X-rays were performed in the 2nd,4th,6th and 8th week after intervention. Results: The height of intervertebral spaces, hydration and viable cell number of intervertebral disc in traction group gradually increased and annular fibrous arranged regularly. Conclusion: Gravitational traction may delay and inhibit intervertebral disc degeneration by increasing the number of viable disc cells and rehydration.

参考文献/References:

[1] Kallb S,Martirosyan NL,Kalani MY,et al.Genetics of the degenerated intervertebral disc[J].World Neurosurgery,2012,77(3/4):491-501.
[2] Clarke J,van Tulder M,Blomberg S,et al.Traction for low back pain with or without sciatica:an updated systematic review within the framework of the cochrane collaboration[J].Spine(Phila Pa 1976),2006,31(14):1591-1599.
[3] Gay RE,Bronfort G,Evans RL,et al.Distraction manipulation of the lumbar spine:a review of the literature[J].J Manipulative Physiol Ther,2005,28(4):266-273.
[4] 杜炎鑫,佟德民,邓晋丰,等.纤维环穿刺法建立兔腰椎间盘退变模型[J].南京中医药大学学报,2013,29(9):459-460.
[5] An HS,Takegami K,Kamada H,et al. Intradiscal administration of osteogenic protein-1increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits [J]. Spine(Phila Pa 1976),2005,30(1):25-31.
[6] Hee HT,Chuah YJ,Tan BH,et al.Vascularization and morphological changes of the endplate after axial compression and distraction of the intervertebral disc[J].Spine(Phila Pa 1976),2011,36(7):505-511.
[7] Guehring T,OmLor GW,Lorenz H,et al.Disc distraction shows evidence of regenerative potential in degenerated intervertebral discs as evaluated by protein expression,magnetic resonance imaging,and messenger ribonucleic acid expression analysis[J].Spine(Phila Pa 1976),2006,31(15):1658-1665.
[8] Unglaub F,Guehring T,Omlor G,et al.Controlled distraction as a therapeutic option in moderate degeneration of the intervertebral disc-an in vivo study in the rabbit-spine model[J].Z Orthop J,2006,144(1):68-73.
[9] Lai A,Chow DH.Effects of traction on structural properties of degenerated disc using an in vivo rat-tail model[J].Spine(Phila Pa 1976),2010,35(14):1339-1345.

备注/Memo

备注/Memo:
收稿日期:2015-02-13
基金项目:广东省科技计划项目(2009B030801292)
更新日期/Last Update: 2015-07-10