[1]刘耶露,潘赐明,杨树明,等.髌骨软化症中医证型演变及中医证素分布研究[J].中国中医骨伤科杂志,2025,33(01):60-64.[doi:10.20085/j.cnki.issn1005-0205.250113]
　LIU Yelu,PAN Ciming,YANG Shuming,et al.Study on the Evolution of TCM Syndrome Types and the Distribution of TCM Syndrome Elements in Chondromalacia Patella[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(01):60-64.[doi:10.20085/j.cnki.issn1005-0205.250113]
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髌骨软化症中医证型演变及中医证素分布研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年01期
页码:
60-64
栏目:
临床论著
出版日期:
2025-01-15

文章信息/Info

Title:
Study on the Evolution of TCM Syndrome Types and the Distribution of TCM Syndrome Elements in Chondromalacia Patella
文章编号:
1005-0205(2025)01-0060-05
作者:
刘耶露1; 2; 潘赐明3; 杨树明4; 陈瑞全1△; 肖洪波1
1安徽中医药大学第一临床医学院(合肥,230031)
2安徽省第二人民医院
3云南中医药大学名医馆
4天长市中医院
Author(s):
LIU Yelu1; 2; PAN Ciming3; YANG Shuming4; CHEN Ruiquan1△; XIAO Hongbo1
1The First Clinical College of Anhui University of Chinese Medicine,Hefei 230031,China; 2Anhui No.2 Provincial People's Hospital,Hefei 230041,China; 3Yunnan University of Chinese Medicine Famous Doctor Museum,Kunming 650500,China; 4Tianchang Hospital of Traditional Chinese Medicine,Tianchang 239300,Anhui China.
关键词:
髌骨软化症;  分期;  中医证素;  危险因素
Keywords:
malacia patella;  stage;  evolution;  TCM syndrome elements;  risk factors
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.250113
文献标志码:
A
摘要:
目的:探讨髌骨软化症不同分期的中医证型演变以及中医证素危险因素分析。方法:收集122例髌骨软化症患者的一般资料,根据磁共振(MR)分期标准统计其中医证型,采用无序多分类Logistic回归分析髌骨软化症证素与危险因素的相关性。结果:髌骨软化症患者不同时期的证型分布差异较大,Ⅰ期以气滞血瘀证(7例,41.18%)为主,Ⅱ期以痰湿痹阻证(16例,53.33%)为主,Ⅲ期以肝肾亏虚证(21例,58.33%)为主,Ⅳ期共计39位患者,以肝肾亏虚证(29例,74.56%)为主。髌骨软化症患者中涉及病性证素包括虚证、痰证、气滞和血瘀; 病位证素包括肝和肾。中医证素与危险因素进行多因素Logistic相关性分析,髌骨软化症患者中年龄是阴虚(OR=7.580)、肝(OR=1.886)和肾(OR=1.807)的独立危险因素(P<0.05),影响程度阴虚>肾; 饮食偏咸是痰湿的独立危险因素(OR=3.989,P<0.05); 体重指数(BMI)亦是痰湿的独立危险因素(OR=4.676,P<0.05); 吸烟是气滞(OR=11.304,P<0.05)和血瘀(OR=10.884,P<0.05)的独立危险因素; 甲状腺功能减退是病位证素肝的独立危险因素(OR=4.299,P<0.05); 腰椎病是病位证素肾的独立危险因素(OR=2.661,P<0.05)。结论:根据临床分期总结了髌骨软化症不同时期的证型分布和动态演变过程,有助于提高临床诊断价值; 中医证素与危险因素(基线资料和合并症)的相关性分析有助于预防本病的发生发展和明确治疗的抓手及切入点。
Abstract:
Objective:To explore the evolution of traditional Chinese medicine(TCM)syndrome types in different stages of chondromalacia patella and to analyze the risk factors of TCM syndrome elements.Methods:The general data of 122 patients with chondromalacia patella were collected,and the evolution of TCM syndrome types was statistically analyzed according to the MR staging standard.The correlation between the syndrome factors of chondromalacia patella and risk factors was analyzed by the disorder multinomial Logistic regression.Results:The distribution of syndrome types in different stages of patients with chondromalacia patella is quite different.In stage Ⅰ,Qi stagnation and blood stasis syndrome(7 cases,41.18%)was the most common syndrome.In stage Ⅱ,obstructive syndrome of phlegm dampness(16 cases,53.33%)was the main type.Stage Ⅲ was mainly liver and kidney deficiency syndrome(21 cases,58.33%).There were 39 patients in stage Ⅳ,mainly with liver-kidney deficiency syndrome(29 cases,74.56%).The disease-related syndromes in patients with chondromalacia patellae include deficiency syndrome,phlegm syndrome,Qi stagnation and blood stasis.The location factors include liver and kidney.Multivariate Logistic regression analysis showed that age was an independent risk factor for Yin deficiency(OR=7.580),liver(OR=1.886)and kidney(OR=1.807)in patients with chondromalacia patella(P<0.05),and the influence of Yin deficiency was greater than kidney.Salty diet was an independent risk factor for phlegm dampness(OR=3.989,P<0.05).BMI was also an independent risk factor for phlegm dampness(OR=4.676,P<0.05).Smoking was an independent risk factor for Qi stagnation(OR=11.304,P<0.05)and blood stasis(OR=10.884,P<0.05).Hypothyroidism was an independent risk factor for the presence of hepatosclerosis syndrome(OR=4.299,P<0.05).Lumbar disease was an independent risk factor for disease position syndrome(OR=2.661,P<0.05).Conclusion:This study summarizes the syndrome distribution and dynamic evolution process of chondromalacia patella in different stages according to the clinical stages,which is helpful to improve the clinical diagnostic value.The correlation analysis between TCM syndrome elements and risk factors(baseline data and complications)is helpful to prevent the occurrence and development of this disease and clarify the starting point of treatment.

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备注/Memo

备注/Memo:
基金项目:安徽省2020年度中央财政中医药事业传承与发展专项资金项目(皖卫中医药发〔2020〕5号)
安徽省2022年度省级临床重点专科建设项目(皖卫医秘〔2022〕105号)
云南省科技厅科技人才与平台计划——云南省中医药学分子生物学重点实验室项目(2019DG016)
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更新日期/Last Update: 2025-01-15