[1]计颖颖,张礼娟,赵增趁.中药熏洗联合火龙灸治疗膝骨关节炎的临床研究[J].中国中医骨伤科杂志,2024,32(11):27-31.[doi:10.20085/j.cnki.issn1005-0205.241106]
　JI Yingying,ZHANG Lijuan,ZHAO Zengchen.Clinical Study of Fumigation and Washing with Traditional Chinese Medicine Combined with Huolong Moxibustion on the Treatment of Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2024,32(11):27-31.[doi:10.20085/j.cnki.issn1005-0205.241106]
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中药熏洗联合火龙灸治疗膝骨关节炎的临床研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第32卷
期数:
2024年11期
页码:
27-31
栏目:
临床研究
出版日期:
2024-11-15

文章信息/Info

Title:
Clinical Study of Fumigation and Washing with Traditional Chinese Medicine Combined with Huolong Moxibustion on the Treatment of Knee Osteoarthritis
文章编号:
1005-0205(2024)11-0027-05
作者:
计颖颖1; 张礼娟1; 赵增趁1
1浙江中医药大学附属湖州中医院(浙江 湖州,313000)
Author(s):
JI Yingying1; ZHANG Lijuan1; ZHAO Zengchen1
1Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University,Huzhou 313000,Zhejiang China.
关键词:
中药熏洗;  火龙灸;  膝骨关节炎;  软骨损伤
Keywords:
traditional Chinese medicine fumigation and washing;  Huolong moxibustion;  knee osteoarthritis;  cartilage injury
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.241106
文献标志码:
A
摘要:
目的:研究中药熏洗联合火龙灸治疗膝骨关节炎的临床疗效。方法:选择2023年1月至2024年1月收治的104例风寒湿痹型膝骨关节炎患者,采用随机数字表法分为两组,每组各52例。对照组采用中药熏洗治疗,观察组采用中药熏洗联合火龙灸治疗。观察两组患者临床疗效、膝关节活动度、关节功能、疾病程度、软骨损伤指标基质金属蛋白酶-3(MMP-3)、基质金属蛋白酶抑制剂-1(TIMP-1)及Wnt/β-连环蛋白(β-catenin)通路因子表达量及不良反应。结果:观察组患者总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者膝关节活动度、美国特种外科医院(HSS)评分高于对照组,西安大略和麦克马斯特大学(WOMAC)评分、MMP-3、TIMP-1水平、Wnt-5a、β-catenin表达量低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应比较,差异无统计学意义(P>0.05)。结论:中药熏洗联合火龙灸治疗风寒湿痹型膝骨关节炎疗效理想,其可能通过抑制Wnt/β-catenin通路活性、修复软骨损伤来发挥治疗作用。
Abstract:
Objective:To study the clinical efficacy of traditional Chinese medicine fumigation and washing combined with Huolong moxibustion on the treatment of knee osteoarthritis.Methods:From January 2023 to January 2024,104 patients with knee osteoarthritis caused by wind-cold-damp syndrome were selected and divided into two groups by random number table method,with 52 cases in each group.The control group was treated with traditional Chinese medicine fumigation,and the observation group was treated with traditional Chinese medicine fumigation combined with Huolong moxibustion.The clinical efficacy,knee joint activity,joint function,degree of disease,cartilage injury index matrix metalloproteinase-3(MMP-3),tissue inhibitor of metalloproteinase-1(TIMP-1)and Wnt/β-catenin pathway factor expression and adverse reactions were observed in the two groups.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).The knee joint activity and HSS score of the observation group were higher than those of the control group,and the WOMAC score,MMP-3,TIMP-1 levels,Wnt-5a and β-catenin expression were lower than those of the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Traditional Chinese medicine fumigation and washing combined with Huolong moxibustion is effective on the treatment of knee osteoarthritis with wind-cold-damp obstruction,which may play a therapeutic role by inhibiting the activity of Wnt/β-catenin pathway to repair cartilage damage.

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备注/Memo

备注/Memo:
基金项目:湖州市科学技术局项目(2019GYB07)
更新日期/Last Update: 2024-11-05