[1]周海东,卢姚宏,王力,等.加味当归芍药散治疗脾虚湿瘀痹阻型膝骨关节炎的临床疗效观察[J].中国中医骨伤科杂志,2024,32(05):36-40.[doi:10.20085/j.cnki.issn1005-0205.240507]
　ZHOU Haidong,LU Yaohong,WANG Li,et al.Observation on the Clinical Efficacy of Danggui Shaoyao Powder on the Treatment of Knee Osteoarthritis with Dampness-Stasis Obstruction[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2024,32(05):36-40.[doi:10.20085/j.cnki.issn1005-0205.240507]
点击复制

加味当归芍药散治疗脾虚湿瘀痹阻型膝骨关节炎的临床疗效观察()
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第32卷
期数:
2024年05期
页码:
36-40
栏目:
临床研究
出版日期:
2024-05-15

文章信息/Info

Title:
Observation on the Clinical Efficacy of Danggui Shaoyao Powder on the Treatment of Knee Osteoarthritis with Dampness-Stasis Obstruction
文章编号:
1005-0205(2024)05-0036-05
作者:
周海东1; 卢姚宏1; 王力2; 胡梁深3; 周明3; 龚礼3; 于江涛3; 陶志强3; 范少勇3△
1江西中医药大学(南昌,330004)
2江西中医药大学附属医院
3南昌市洪都中医院
Author(s):
ZHOU Haidong1; LU Yaohong1; WANG Li2; HU Liangshen3; ZHOU Ming3; GONG Li3; YU Jiangtao3; TAO Zhiqiang3; FAN Shaoyong3△
1Jiangxi University of Chinese Medicine,Nanchang 330004,China; 2Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China; 3Nanchang Hongdu Hospital of Traditional Chinese Medicine,Nanchang 330006,China.
关键词:
加味当归芍药散;  膝骨性关节炎;  脾虚湿瘀痹阻型
Keywords:
Danggui Shaoyao powder;  knee osteoarthritis;  wet stasis arthralgia type
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.240507
文献标志码:
A
摘要:
目的:观察加味当归芍药散治疗脾虚湿瘀痹阻型膝骨关节炎的临床疗效。方法:选择符合纳入标准的受试者82例,以随机数字表法将其分为治疗组和对照组,每组41例; 治疗组予加味当归芍药散颗粒剂内服治疗,对照组口服塞来昔布胶囊,两组均连续治疗4周,记录两组受试者治疗前后的西安大略和麦克马斯特大学(WOMAC)骨关节炎指数、Lysholm评分、视觉模拟量表(VAS)评分以及疗效指数判断其疗效,记录整个治疗过程中的不良反应以评价其安全性,并在结束治疗6个月后进行随访,记录其复发率。结果:结束治疗后,治疗组VAS评分和WOMAC评分均低于对照组,差异有统计学意义(P<0.05); 治疗组Lysholm评分高于对照组,差异有统计学意义(P<0.05)。治疗组的总有效率(92.68%)优于对照组(80.49%),治疗组的复发率(10.50%)低于对照组(30.30%)。治疗期间各组未见明显不良反应。结论:加味当归芍药散在改善脾虚湿瘀痹阻型膝骨关节炎患者疼痛及功能障碍方面的效果更明显,且复发率低,无不良反应及毒副反应,用药安全性高,可广泛应用于临证治疗。
Abstract:
Objective:To observe the clinical efficay of Danggui Shaoyao powder on the treatment of knee osteoarthritis with dampness-stasis obstruction.Methods:82 subjects meeting the inclusion criteria in our hospital were selected and divided into treatment group and control group by random number table method,with 41 cases in each group.The treatment group was orally treated with Danggui Shaoyao powder supplemented granules,while the control group was orally treated with cecoxib capsule.Both groups were treated for 4 weeks continuously.The efficacy of the two groups was evaluated by recording the results of Western Ontario and McMaster Universities(WOMAC)osteoarthritis index,Lysholm scores,visual analogue scale(VAS)scores and efficacy index before and after treatment,and the adverse reactions during the whole treatment process were recorded to evaluate its safety.The recurrence rate was recorded at 6 months after the end of treatment.Results:VAS and WOMAC scores in the treatment group were lower than those in the control group after treatment(P<0.05).Lysholm scores in the treatment group were higher than those in the control group(P<0.05).The total effective rate of the treatment group(92.68%)was better than that of the control group(80.49%),the recurrence rate of the treatment group was 10.50%,lower than 30.30% of the control group,and no obvious adverse reactions were observed in each group during treatment.Conclusion:Danggui Shaoyao powder can improve the pain and dysfunction of patients with damp-stasis arbi knee osteoarthritis more obviously,and the recurrence rate is low,no adverse reactions and side efficacy,high drug safety,and can be widely applied to clinical treatment.

参考文献/References:

[1] 中国中医药研究促进会骨伤科分会.膝骨关节炎中医诊疗指南(2020年版)[J].中医正骨,2020,32(10):1-14.
[2] STOPPIELLO L A, MAPP PI, WILSON D, et al.Structural associations of symptomatic knee osteoarthritis[J].Arthritis Rheumatol,2014,66(11):3018-3127.
[3] CUI A, LI H, WANG D, et al.Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies[J].EClinicalMedicine,2020,29-30:100587.
[4] 周海东,王力,卢姚宏,等.王力从湿瘀论治膝骨性关节炎的临证经验[J].江西中医药,2023,54(1):21-23.
[5] 中华医学会骨科学分会关节外科学组.骨关节炎诊疗指南(2018年版)[J].中华骨科杂志,2018,38(12):705-715.
[6] 国家食品药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:349-353.
[7] 陈家旭.中医诊断学[M].北京:人民卫生出版社,2012:263.
[8] 司元龙,冯康虎,陈志伟,等.中医药防治膝关节软骨退变的研究进展[J].中医临床研究,2022,14(16):124-127.
[9] GOLDRING M B, GOLDRING S R.Osteoarthritis[J].J Cell Physiol,2007,213(3):626-634.
[10] 邬爽,侯冉冉,李秋,等.丹参地上部分丹酚酸A的抗炎活性及对p38MAPK通路的影响[J].黑龙江畜牧兽医,2020(8):119-123.
[11] 贾娜,崔佳,赵超,等.大叶秦艽花环烯醚萜类成分对胶原诱导性关节炎小鼠的治疗作用及相关机制探讨[J].中国免疫学杂志,2018,34(10):1483-1486.
[12] 乙军,周业庭,潘武,等.独活挥发油灌胃对兔膝骨关节炎的保护作用及其机制[J].临床骨科杂志,2013,16(4):451-454.
[13] 黄艳峰,谢新宇,林晴,等.基于计算机模拟探讨牛膝治疗骨关节炎软骨退变机制[J].中国实验方剂学杂志,2021,27(15):148-155.
[14] 张学良,宋敏,宋贵杰.骨内高压致骨性关节炎机理的探讨[J].颈腰痛杂志,2006(4):327-329.
[15] 罗宝生.当归与川芎药理作用研究进展及对比[J].中国处方药,2016,14(5):20-22.
[16] 黄红泓,覃日宏,柳贤福.中药当归的化学成分分析与药理作用探究[J].世界最新医学信息文摘,2019,19(58):127.
[17] 袁子文,钟立甲,纪鹏,等.当归干预血瘀证大鼠血浆代谢组学研究[J].天然产物研究与开发,2018,30(4):559-567.

备注/Memo

备注/Memo:
△通信作者 E-mail:fansy0000@163.com
更新日期/Last Update: 2024-05-15