[1]袁一峰 黄小生 杨依然 刘康 史晓林.金天格胶囊对原发Ⅰ型骨质疏松症患者下肢功能的影响[J].中国中医骨伤科杂志,2019,27(08):24-27.
 YUAN Yifeng HUANG Xiaosheng YANG Yiran LIU Kang SHI Xiaolin.Study on Effect of Jintiange Capsules on Lower Limb Function in Patients with Primary Type Ⅰ Osteoporosis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2019,27(08):24-27.
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金天格胶囊对原发Ⅰ型骨质疏松症患者下肢功能的影响()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第27卷
期数:
2019年08期
页码:
24-27
栏目:
临床研究
出版日期:
2019-07-30

文章信息/Info

Title:
Study on Effect of Jintiange Capsules on Lower Limb Function in Patients with Primary Type Ⅰ Osteoporosis
文章编号:
1005-0205(2019)08-0024-04
作者:
袁一峰1 黄小生1 杨依然1 刘康2 史晓林2
1浙江中医药大学第二临床医学院(杭州,310053) 2浙江中医药大学附属第二医院
Author(s):
YUAN Yifeng1 HUANG Xiaosheng1 YANG Yiran1 LIU Kang2 SHI Xiaolin2△
1The Second Clinical Medical College of Zhejiang Chinese Traditional Medical University,Hangzhou 310053,China; 2The Second Affiliated Hospital of Zhejiang Chinese Traditional Medical University,Hangzhou 310005,China.
关键词:
金天格胶囊 原发Ⅰ型骨质疏松症 下肢功能
Keywords:
Jintiange capsules primary type Ⅰ osteoporosis lower limb function
分类号:
R274.39
文献标志码:
A
摘要:
目的:探讨金天格胶囊对原发Ⅰ型骨质疏松症患者下肢功能的影响。方法:采用临床随机对照的方法,将160例符合纳入标准的原发Ⅰ型骨质疏松患者随机分为对照组和治疗组:治疗组给予金天格胶囊; 对照组给予钙尔奇D片。疗程为12周。治疗前后分别比较患者的SPPB(简易机体功能评估量表),TUG(计时起走测试),BMD(骨密度),RASM(四肢骨骼肌指数)以及股四头肌力,SPPB包括5次坐立测试、串联站立测试和2.44 m行走测试。结果:除RASM外,治疗组的各项研究指标均优于治疗前,差异有统计学意义(P<0.05); 对照组则同治疗前差异无统计学意义(P>0.05)。结论:金天格胶囊能够有效地改善和增强原发 I型骨质疏松患者的下肢功能,减少患者发生跌倒事件的概率,从而起到有效预防骨质疏松性骨折的效果。
Abstract:
Objective: To investigate the effect of Jintiange capsules on lower limb function in patients with primary type I osteoporosis.Methods: 160 patients with primary type I osteoporosis who met the inclusion criteria were randomly divided into control group and treatment group by clinical randomized control method.The treatment group was given Jintiange capsules and the control group was given calcium carbonate and vitamin D3 tablets.The course of treatment was 12 weeks.The SPPB(short physical performance battery),TUG(timed up and go test),BMD(bone density),RASM(skeletal muscle index of limbs)and quadriceps muscle strength of the patients were compared before and after treatment,and the SPPB included five sitting test,tandem standing test and 2.44 m walking test.Results: Except for RASM,all the research indexes in the treatment group were better than before,and the difference was statistically significant(P<0.05).There was no significant difference between the control group and the group before treatment(P>0.05).Conclusion: Jintiange capsules can effectively improve and enhance the lower limb function of patients with primary type I osteoporosis,reduce the probability of falling events in patients,and thus effectively prevent osteoporotic fractures.

参考文献/References:

[1] LUPSA B C,INSOGNA K.Bone health and osteoporosis[J].Endocrinol Metab Clin North Am,2015,44(3):517-530. [2] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊治指南(2011)[J].中华骨质疏松和骨矿盐疾病杂志,2011,4(1):2-17. [3] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2017)[J].中国实用内科杂志,2018,38(2):127-150. [4] MATHIAS S,NAYAK U S,ISAACS B.Balance in elderly patients:the “get-up and go” test[J].Arch Phys Med Rehabil,1986,67(6):387-389. [5] 刘刚,唐瑭,刘晶晶.阿仑膦酸钠联合钙尔奇d治疗老年骨质疏松62例[J].中国老年学,2012,32(18):4070-4071. [6] GURALNIK J M,FERRUCCI L,PIEPER C F,et al.Lower extremity function and subsequent disability:consistency across studies,predictive models,and value of gait speed alone compared with the short physical performance battery[J].J Gerontol A Biol Sci Med Sci,2000,55(4):221-231. [7] ZHU K,DEVINE A,LEWIS J R,et al.Timed up and go' test and bone mineral density measurement for fracture prediction[J].Arch Intern Med,2011,171(18):1655-1661. [8] 刘元标,励建安.老年人跌倒与平衡及步态异常[J].中国康复理论与实践,2012,18(1):5-8. [9] 任海静,胡景萍,任海妹.老年人肌力减退及预防的研究进展[J].中国老年学杂志,2013,33(21):5484-5487.[10] MULLENDER M G,HUISKES R,WEINANS H.A physiological approach to the simulation of bone remodeling as a self-organizational control process[J].J Biomech,1994,27(11):1389-1394. [11] WEINANS H,HUISKES R,GROOTENBOER H J.The behavior of adaptive bone-remodeling simulation models[J].J Biomech,1992,25(12):1425-1441. [12] 聂伟志,石关桐.生物力学因素与女性骨质疏松症病人骨密度的关系[J].中国中医骨伤科杂志,2002,10(3):1-6. [13] MILLER P D.Management of severe osteoporosis[J].Expert Opin Pharmacother,2016,17(4):473-488. [14] XIE Y M,YUWEN Y,DONG F H,et al.Clinical practice guideline of traditional medicine for primary osteoporosis[J].Chin J Integr Med,2011,17(1):52-63. [15] 薛鹏,李玉坤.2017年版《原发性骨质疏松症诊疗指南》解读[J].河北医科大学学报,2018,39(1):1-6. [16] 张军,吴林生,孙树椿,等.金天格胶囊治疗原发性骨质疏松症660例临床疗效[J].中国骨质疏松杂志,2005,11(4):82-87. [17] 程栋,龙攀,周海艇,等.中医药治疗骨质疏松症研究近况[J].中国骨质疏松杂志,2003,9(1):86-89. [18] 陈鸿颜,王超群,周影,等.金天格胶囊的短期疗效及其对骨转化标志物的影响:基于44名志愿者的研究报告[J].中国骨质疏松杂志,2015,21(8):977-979.

备注/Memo

备注/Memo:
通信作者 E-mail:xlshi-2002@163.com(收稿日期:2018-12-04)
更新日期/Last Update: 1900-01-01