[1]龚幼波 张琥 杜敏 张云飞 龚玉阳.痹祺胶囊治疗肝肾亏虚型膝关节炎疗效及对患者红细胞免疫功能变化的影响[J].中国中医骨伤科杂志,2019,27(08):15-19.
　GONG Youbo ZHANG Hu DU Min ZHANG Yunfei GONG Yuyang.The Clinical Efficacy of Biqi Capsule on Gonarthritis of Liver and Kidney Deficiency Type and Its Impact on Red Blood Cell Immune Function in Patients[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2019,27(08):15-19.
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痹祺胶囊治疗肝肾亏虚型膝关节炎疗效及对患者红细胞免疫功能变化的影响()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第27卷
期数:
2019年08期
页码:
15-19
栏目:
临床研究
出版日期:
2019-07-30

文章信息/Info

Title:
The Clinical Efficacy of Biqi Capsule on Gonarthritis of Liver and Kidney Deficiency Type and Its Impact on Red Blood Cell Immune Function in Patients
文章编号:
1005-0205(2019)08-0015-05
作者:
龚幼波1 张琥1 杜敏2 张云飞1 龚玉阳3
1上海中医药大学附属曙光医院骨伤科(上海,201203) 2兰州市西固区中医院骨伤科 3安徽省宿松县工农社区卫生服务站
Author(s):
GONG Youbo1 ZHANG Hu1△ DU Min2 ZHANG Yunfei1 GONG Yuyang3
1Department of Orthopedics and Traumatology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China; 2Xigu District Traditional Chinese Medicine Hospital of Lanzhou City,Lanzhou 730000,China; 3Workers and Peasants Community Health Service Station in Susong County,Susong 246501,Anhui China.
关键词:
痹祺胶囊;  膝关节炎;  肝肾亏虚证;  红细胞免疫功能
Keywords:
Biqi capsule;  gonarthritis;  liver and kidney deficiency syndrome;  red blood cell immune function
分类号:
R684.3
文献标志码:
A
摘要:
目的:探讨痹祺胶囊治疗肝肾亏虚型膝关节炎的临床效果及对患者红细胞免疫功能变化的影响。方法:选择2017年2月至2018年6月来本院就诊的膝关节炎(肝肾亏虚证)患者136例作为研究对象,采用随机数字表将其分成两组,每组68例。对照组关节腔内注射玻璃酸钠治疗,观察组在此基础上口服痹祺胶囊,所有患者均治疗8周。比较两组临床疗效,治疗前后红细胞C3b受体(E-C3bRR)和免疫复合物花环率(E-ICR)、相关量表(视觉模拟评分法(VAS)、西安大略和麦克马斯特大学(WOMAC)骨关节炎指数、36项健康调查简表(SF-36))评分及中医证候积分变化。结果:两组患者基线资料差异无统计学意义(P>0.05),观察组总有效率为94.12%(64/68),与对照组的76.47%(52/68)相比差异有统计学意义(P<0.05)。两组治疗后外周血E-C3bRR值和SF-36评分均较治疗前显著增高,差异有统计学意义(P<0.05),外周血E-ICR值和疼痛VAS评分及WOMAC评分较治疗前均显著下降,差异有统计学意义(P<0.05),且观察组改善更显著,差异有统计学意义(P<0.05)。两组治疗后各项中医证候积分有明显减少,差异有统计学意义(P<0.05),且治疗后观察组膝关节疼痛、腰膝沉重、下肢酸楚、行走痛或不适积分均显著低于对照组同期,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:痹祺胶囊治疗肝肾亏虚型膝关节炎可正向调节机体红细胞免疫功能,改善患者膝关节功能,提高生活质量,临床疗效确切。
Abstract:
Objective: To investigate the clinical efficacy of Biqi capsule on gonarthritis of liver and kidney deficiency type.Methods: The subjects of this study,136 patients with gonarthritis(liver and kidney deficiency syndrome)admitted in our hospital from February 2017 to June 2018,were divided into two groups on the basis of random number table,each with 68 cases.The control group was given sodium hyaluronate injection into the knee function,while the observation group Biqi capsule for oral administration in addition to what was applied to the control group.All patients were treated for 8 weeks.The clinical efficacy of the two groups was compared before and after treatment.Erythrocyte C3b receptor rosette rate(E-C3bRR)and immune complex rosette rate(E-ICR)and scores and changes in TCM syndrome scores of related scales(Visual Analogue Scale(VAS),Western Ontario and McMaster University(WOMAC)Osteoarthritis Index,36 items Health Survey Summary(SF-36)).Results: There was no statistical difference in baseline data between the two groups(P>0.05).The overall effective rate of the observation group was 94.12%(64/68),much higher than 76.47%(52/68)of the control group(P<0.05).After treatment both groups saw much higher E-C3bRR values and SF-36 scores but obviously lower E-ICR values,VAS scores for pain,WOMAC scores as compared with those before treatment(P<0.05),and the improvement in above indicators the observation group gained was more significant(P<0.05).The traditional Chinese medicine syndrome scores of two groups after treatment decreased remarkably(P<0.05),and the observation group had much lower scores for pain in knee joint,soreness of waist and knees,weakness of lower limbs,aches and pains while walking than the control group did over identical period(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion: In treating gonarthritis of liver and kidney deficiency type the application of Biqi capsule can positively regulate red blood cell immune function,improve knee joint function in patients,better life quality,proving to be clinically effective.

参考文献/References:

[1] NIU J,CLANCY M,ALIABADI P,et al.Metabolic syndrome,its components,and knee osteoarthritis:the framingham osteoarthritis study[J].Arthritis & Rheumatology,2017,69(6):1194-1203. [2] BHANDARI M,BANNURU R R,BABINS E M,et al.Intra-articular hyaluronic acid in the treatment of knee osteoarthritis:a canadian evidence-based perspective[J].Ther Adv Musculoskelet Dis,2017,9(9):231-246. [3] 刘昊,张岩,孙晓新,等.痹祺胶囊联合膝关节支具治疗膝骨性关节炎的临床观察[J].中国煤炭工业医学杂志,2016,19(7):1008-1010. [4] 张建.痹祺胶囊联合玻璃酸钠治疗膝骨性关节炎的临床研究[J].现代药物与临床,2017,32(12):2438-2441. [5] 中华医学会风湿病学分会.骨关节炎诊断及治疗指南[J].中华风湿病学杂志,2010,14(6):416-419. [6] 国家食品药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002. [7] KRAUS V B,COLLINS J E,HARGROVE D,et al.Predictive validity of biochemical biomarkers in knee osteoarthritis:data from the FNIH OA biomarkers consortium[J].Annals of the Rheumatic Diseases,2017,76(1):186-195. [8] TIULPIN A,THEVENOT J,RAHTU E,et al.Automatic knee osteoarthritis diagnosis from plain radiographs:a deep learning-based approach[J].Scientific Reports,2018,8(1):1727-1733. [9] 陈志伟,张钰敏,方晓明,等.火龙灸结合电针治疗寒湿型退行性膝关节炎30例[J].中国中医骨伤科杂志,2018,26(5):72-74. [10] 张瑞鹏,李石伦,尹英超,等.腓骨截骨+胫骨高位截骨四点支撑钢板撑开固定治疗重度骨性膝关节炎[J].河北医科大学学报,2018,39(10):1224-1226. [11] 鞠昌军,严伟,姜红江,等.外翻支具辅助下行细胞因子关节腔注射治疗膝关节炎50例[J].中国中医骨伤科杂志,2017,25(12):59-61. [12] 李凤玲,陈洁.膝关节骨性关节炎的中医辨证施护及通络治疗[J].中华现代护理杂志,2016,22(29):4160-4162. [13] 王柏公,王丽萍,白人骁.痹祺胶囊治疗膝骨性关节炎的多中心随机对照临床试验[J].中华中医药杂志,2017,32(8):3840-3843. [14] 李芳,姚建华,郑桂敏,等.痹祺胶囊对骨关节炎患者血清IL-1、MMP-3和TIMP-1表达的影响[J].中华中医药杂志,2016,31(1):300-302. [15] 徐艳明,荣晓凤,谭洪发,等.痹祺胶囊对类风湿性关节炎CIA大鼠JAK-STAT信号通路的影响[J].免疫学杂志,2015,31(12):1072-1076. [16] 徐艳明,荣晓凤,谭洪发,等.痹祺胶囊对CIA大鼠OPG/RANKL表达的影响[J].免疫学杂志,2016,32(10):878-883. [17] 卫芳征.外周血T细胞亚群和红细胞免疫功能与重症肺结核患者不良预后的相关性[J].临床肺科杂志,2018,23(9):1561-1565. [18] CALABRO S,GALLMAN A,GOWTHAMAU U,et al.Bridging channel dendritic cells induce immunity to transfused red blood cells[J].Journal of Experimental Medicine,2016,213(6):887-896.

备注/Memo

备注/Memo:
基金项目:“中医骨伤科学”国家重点学科项目(100508) 上海市名老中医学术经验研究工作室 (SHGZS-2017025) “上海市重中之重重点学科(中医骨伤科学)”重中之重临床医学中心和重点学科建设项目(2017ZZ02024)通信作者 E-mail:zhang_hu@126.com(收稿日期:2019-04-08)
更新日期/Last Update: 1900-01-01