[1]顾鸣 马勇△ 郭杨 陈雯玥 孙杰 司誉豪 王礼宁.基于中医传承辅助系统的马勇治疗颈椎病用药规律分析[J].中国中医骨伤科杂志,2019,27(01):22-26.
　GU Ming MA Yong GUO Yang CHEN Wenyue SUN Jie SI Yuhao WANG Lining.Analysis of Laws of Compositions and Medications for Treating Cervical Spondylosis Based on the Inheritance Platform of Traditional Chinese Medicine[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2019,27(01):22-26.
点击复制

基于中医传承辅助系统的马勇治疗颈椎病用药规律分析()
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第27卷
期数:
2019年01期
页码:
22-26
栏目:
临床研究
出版日期:
2019-01-15

文章信息/Info

Title:
Analysis of Laws of Compositions and Medications for Treating Cervical Spondylosis Based on the Inheritance Platform of Traditional Chinese Medicine
文章编号:
1005-0205(2019)01-0022-05
作者:
顾鸣1 马勇1△ 郭杨1 陈雯玥1 孙杰1 司誉豪1 王礼宁1
南京中医药大学(南京,210023)
Author(s):
GU Ming1 MA Yong1△ GUO Yang1 CHEN Wenyue1 SUN Jie1 SI Yuhao1 WANG Lining1
Nanjing University of Chinese Medicine,Nanjing 210023,china.
关键词:
颈椎病;  中医传承辅助平台;  组方用药规律
Keywords:
cervical spondylosis;  TCM inheritance support system;  laws of compositions and medications
分类号:
R681.5
文献标志码:
A
摘要:
借助中医传承辅助系统(V2.5),探讨马勇教授治疗颈椎病的用药经验。方法:收集马勇教授治疗颈椎病的门诊处方,通过使用中医传承辅助系统中的熵聚类及关联规则等方法挖掘出马勇教授的组方特点和用药规律。结果:1)共计纳入253首处方,涉及65种药物,累计使用频次共3 205次。2)使用频次在18次以上的药物共28种,其中使用频次最高(114次以上,为高频使用药物)的14味药物分别为黄芪、桂枝、炒白芍、鸡血藤、附子、干姜、当归、炙甘草、威灵仙、川芎、葛根、枳壳、木瓜、桃仁。3)依据方剂数量,设置相关度(药物与药物之间的关联度)为8,惩罚度(减少负面数据信息干扰的参数)为2,基于改进的互信息法,得到23个关联系数大于0.155的药对。4)通过复杂系统熵聚类方法,按照相关度为8以及惩罚度为2的约束条件以及无监督的熵层次聚类,得出3～4味药物的核心组合10个,组合、演化出新处方3首。结论:总结出28味高频用药23个常用药对,10个核心药组,3首新处方; 马勇教授治疗颈椎病常以补为主,以通为用,辅以祛邪,切合脾肾亏虚、肝肾不足、风寒湿邪侵袭的病机; 中医传承辅助系统可用于名老中医经验的研究。
Abstract:
To analyze laws of compositions and medications for cervical spondylosis based on the inheritance platform of traditional Chinese medicine(Version 2.5). Methods:Prescriptions were gathered according to Professor Ma Yong's outpatients on treating cervical spondylosis,which characteristics and medication rules were analyzed by association rule mining and complex system entropy cluster in TCM inheritance support system. Results:1)A total of 253 recipes were screened, including 65 drugs with a grand total frequency of usage of 3 205.2)There are 28 drugs in the prescription whose frequency are beyond 18.Among 14 highest frequency using drugs(high frequency of use over 114 times is high frequency of using drugs )were Huangqi,Guizhi,Chaobaishao,Jixueteng,Fuzi,Ganjiang,Danggui,Zhigancao,Weilingxian,Chuanxiong,Gegen,Zhike,Mugua,Taoren.3)Based on the quantity of recipes and improved mutual information method, 23 couplet medicines that correlation coefficient was more than 0.155 were obtained whose relevance(degree of association between drugs and drugs)was set as 8 and the punishment degree(parameters that reduce the negative information interference)was 2.4)According to the complex system entropy clustering and the constraints of correlation degree as 8 and penalty as 2,there were 10 core combinations and 3 new recipes. Conclusion:A total of 28 high frequency drugs,23 common drug pairs,10 core drug combinations,and 3 new prescriptions were summarized. Professor Ma Yong has rich clinical experience in the treatment of cervical spondylosis using supplementation. Fulfilling their purposes when there is free flow,supplemented by dispel evil. Catering to the pathogenesis of spleen and kidney deficiency, liver and kidney insuffciency,invasion by exogenous pathogenic wind, cold and dampness. TCM inheritance support system can be used for the study of experience of famous and veteran doctors of TCM.

参考文献/References:

[1] 唐仕欢,申丹,卢朋,等.中医传承辅助平台应用评述[J].中华中医药杂志,2015,30(2):329-331.
[2] 国家药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2010.
[3] 杨洪军,唐仕欢,卢鹏.中医传承辅助平台的开发与应用[M].福州:福建科学技术出版社,2013.
[4] 杨洪军,赵亚丽,唐仕欢,等.基于熵方法分析中风病方剂中药物之间关联度[J].中国中医基础医学杂志,2005,11(9):706-709.
[5] 唐仕欢,陈建新,杨洪军,等.基于复杂熵聚类方法的中药新药处方发现研究思路[J].世界科学技术:中医药现代化,2009,11(2):225-228.
[6] 李健,卢朋,唐仕欢,等.基于中医传承辅助系统的治疗肺痈方剂用药规律分析[J].中国实验方剂学杂志,2012,18(2):254-258.
[7] 田代华(整理).黄帝内经·素问[M].北京:人民卫生出版社,2005.
[8] 王肯堂.证治准绳(一)杂病证治准绳[M].北京:人民卫生出版社,2014.
[9] 丁光迪.诸病源候论校注[M].北京:人民卫生出版社,2013.
[10] 陈斌,袁普卫,康武林,等.黄芪桂枝五物汤在骨伤科的应用进展[J].中国中医骨伤科杂志,2015,23(5):71-74.
[11] 郭平,王浩,王晶.补阳还五汤对实验性脑缺血再灌注损伤抗氧化作用的研究[J].山东中医杂志,2001(10):621-623.
[12] 韩岚,彭代银,许钒,等.桃红四物汤抗血小板活化作用及机制研究[J].中国中药杂志,2010,35(19):2609-2612.
[13] WATANUKI A.The effect of the sympathetic nervous system on cervical spondylosis[J].Nippon Seikeigeka Gakkai Zasshi,1981,55(4):371-385.
[14] 赵延龙.中药黄芪的临床应用及药理作用分析[J].中医临床研究,2018,10(11):128-129.
[15] 聂安政,林志健,王雨,等.秦艽化学成分及药理作用研究进展[J].中草药,2017,48(3):597-608.
[16] 李乃谦.熟地黄活性成分药理作用的研究进展[J].中国处方药,2017,15(1):14-15.
[17] 费可,胡瑕瑜,邹璐,等.细辛临床应用与药理作用研究进展[J].上海中医药大学学报,2010,24(6):87-90.

备注/Memo

备注/Memo:
基金项目:江苏省研究生实践创新计划(SJCX18_0487) 1南京中医药大学(南京,210023) △通信作者 E-mail:zhongyi-my@263.com
更新日期/Last Update: 2019-01-15