[1]何启旺,王威,张志文,等.基于膝骨关节炎多组织、多表型hub基因的转录组学研究进展[J].中国中医骨伤科杂志,2026,34(08):103-112.[doi:10.20085/j.cnki.issn1005-0205.260814]
　HE Qiwang,WANG Wei,ZHANG Zhiwen,et al.Research Progress on Transcriptomics of Multi-Tissue and Multi-Phenotype hub Genes in Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2026,34(08):103-112.[doi:10.20085/j.cnki.issn1005-0205.260814]
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基于膝骨关节炎多组织、多表型hub基因的转录组学研究进展()

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第34卷
期数:
2026年08期
页码:
103-112
栏目:
文献综述
出版日期:
2026-08-10

文章信息/Info

Title:
Research Progress on Transcriptomics of Multi-Tissue and Multi-Phenotype hub Genes in Knee Osteoarthritis
文章编号:
1005-0205(2026)08-0103-10
作者:
何启旺1; 王威2; 3; 4; 张志文2; 3; 周天乐1; 杨皓程1; 刘曦明4; 董石磊2; 3△
1湖北中医药大学针灸骨伤学院(武汉,430061)
2湖北省中医院(湖北中医药大学附属医院)
3中医肝肾研究及应用湖北省重点实验室
4中国人民解放军中部战区总医院
Author(s):
HE Qiwang1; WANG Wei2; 3; 4; ZHANG Zhiwen2; 3; ZHOU Tianle1; YANG Haocheng1; LIU Ximing4; DONG Shilei2; 3△
1College of Acupuncture and Orthopedics,Hubei University of Chinese Medicine,Wuhan 430061,China; 2Hubei Provincial Hospital of Traditional Chinese Medicine(Affiliated Hospital of Hubei University of Chinese Medicine),Wuhan 430061,China; 3Hubei Key Laboratory of Theory and Application Research of Liver and Kidney in Traditional Chinese Medicine,Wuhan 430061,China; 4General Hospital of Central Theater Command,Wuhan 430070,China.
关键词:
膝骨关节炎;  转录组学;  hub基因;  生物信息学;  精准医疗
Keywords:
knee osteoarthritis;  transcriptomics;  hub gene;  bioinformatics;  precision medicine
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.260814
文献标志码:
A
摘要:
骨关节炎是最常见的关节退行性疾病,严重影响着患者生存质量和医疗保健成本。系统整合近五年膝骨关节炎的转录组学研究,综合运用批量转录组、单细胞转录组及表观转录组等多组学数据,旨在揭示膝骨关节炎的高度异质性分子机制并筛选hub基因。共鉴定出135个hub基因,并成功将其映射至铁死亡、细胞衰老、代谢紊乱等31种核心病理表型; 分析发现铁死亡与细胞衰老是当前研究焦点,且CDKN1A等基因在跨组织研究中被反复验证,凸显了其在病理网络中的核心地位。研究突破了单一组织与表型的传统局限,系统描绘了膝骨关节炎的多维调控图谱,为靶向治疗提供了新视角; 未来研究需借助空间转录组等新兴技术构建完整基因信息流调控网络,以推动膝骨关节炎的精准诊疗。
Abstract:
Osteoarthritis(OA)is the most common degenerative joint disease,severely affecting patients' quality of life and imposing a substantial burden on healthcare systems.This study systematically integrates transcriptomic research on knee osteoarthritis(KOA)conducted over the past five years,leveraging multi-omics data-including bulk RNA-seq,single-cell RNA-seq,and epitranscriptomic profiling-to elucidate the highly heterogeneous molecular mechanisms underlying KOA and identify hub genes.A total of 135 hub genes were identified and successfully mapped to 31 core pathological phenotypes,including ferroptosis,cellular senescence,and metabolic alterations.Analysis revealed that ferroptosis and cellular senescence are current research hotspots; genes such as CDKN1A have been repeatedly validated in cross-tissue studies,highlighting their core position in the pathological network.The research breaks through the traditional limitations of single tissues and phenotypes,systematically depicting the multi-dimensional regulatory landscape of KOA and providing new insights for targeted therapy.Future research should leverage emerging technologies such as spatial transcriptomics to construct a comprehensive regulatory network of gene information flow,thereby promote precise diagnosis and treatment of KOA.

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(收稿日期:2026-01-06)

备注/Memo

备注/Memo:
基金项目:解放军中部战区总医院博士后科研基金项目(20210517KY02)
湖北省自然科学基金创新发展联合基金项目(2022CFD148)
武汉市知识创新专项项目(2023020201010179)
2026年度湖北中医药大学研究生交叉创新基金项目(2026SSCX08)
△通信作者 E-mail:dongshilei666@163.com
更新日期/Last Update: 2026-08-15