[1]赵千乐,袁普卫△,刘德玉,等.基于《金匮要略》血痹理论探讨线粒体自噬与氧化应激调节在膝骨关节炎治疗中的作用[J].中国中医骨伤科杂志,2026,34(08):72-78.[doi:10.20085/j.cnki.issn1005-0205.260810]
　ZHAO Qianle,YUAN Puwei,LIU Deyu,et al.Exploring the Role and Mechanism of Mitophagy and Oxidative Stress Regulation in the Treatment of Knee Osteoarthritis Based on the Blood Impediment Theory in Synopsis of the Golden Chamber[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2026,34(08):72-78.[doi:10.20085/j.cnki.issn1005-0205.260810]
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基于《金匮要略》血痹理论探讨线粒体自噬与氧化应激调节在膝骨关节炎治疗中的作用()

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第34卷
期数:
2026年08期
页码:
72-78
栏目:
经验交流
出版日期:
2026-08-10

文章信息/Info

Title:
Exploring the Role and Mechanism of Mitophagy and Oxidative Stress Regulation in the Treatment of Knee Osteoarthritis Based on the Blood Impediment Theory in Synopsis of the Golden Chamber
文章编号:
1005-0205(2026)08-0072-07
作者:
赵千乐1; 袁普卫1△; 刘德玉2; 康武林2; 杨波2; 董佩1; 赵泽龙1; 李学同1; 尚辉1
1陕西中医药大学(陕西 咸阳,712046)
2陕西中医药大学附属医院
Author(s):
ZHAO Qianle1; YUAN Puwei1△; LIU Deyu2; KANG Wulin2; YANG Bo2; DONG Pei1; ZHAO Zelong1; LI Xuetong1; SHANG Hui1
1Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi China; 2Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi China.
关键词:
膝骨关节炎;  金匮要略;  血痹理论;  线粒体自噬;  氧化应激;  中医药治疗
Keywords:
knee osteoarthritis;  Synopsis of the Golden Chamber;  blood impediment theory;  mitophagy;  oxidative stress;  traditional Chinese medicine treatment
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.260810
文献标志码:
A
摘要:
膝骨关节炎是全球高发的慢性退行性关节疾病,其临床发病机制尚未完全阐明。近年研究表明,软骨细胞线粒体自噬失调与氧化应激失衡形成的恶性循环,是膝骨关节炎进展的核心病理环节。中医药在膝骨关节炎治疗中具有独特优势,《金匮要略》血痹理论以 “本虚标实” 为核心病理模型,其中 “本虚” 可对应线粒体功能衰退、抗氧化能力下降的病理基础,“标实” 则与线粒体自噬及氧化应激失衡的病理状态相契合。基于血痹理论,结合现代医学研究成果,通过文献梳理与理论推演,推测中医药可能通过调节线粒体自噬与氧化应激平衡、打破二者恶性循环发挥干预作用,以期为膝骨关节炎的中医药治疗思路拓展及机制研究提供参考。
Abstract:
Knee osteoarthritis(KOA)is a globally prevalent chronic degenerative joint disease,whose clinical pathogenesis has not been fully elucidated.Recent studies have shown that the vicious cycle formed by the dysregulation of chondrocyte mitophagy and the imbalance of oxidative stress constitutes the core pathological link in the progression of KOA.Traditional Chinese medicine(TCM)has unique advantages in the treatment of KOA.The blood stasis theory from Synopsis of the Golden Chamber takes “deficiency at the root and excess in branch” as its core pathological model,wherein “deficiency in root” can correspond to the pathological basis of mitochondrial dysfunction and decreased antioxidant capacity,while “excess in branch” reflects the pathological state of mitophagy dysregulation and oxidative stress imbalance.Based on the blood impediment theory and combined with modern medical research findings,this paper—through a literature review and theoretical analysis—proposes that TCM may exert therapeutic effects by regulating the balance between mitophagy and oxidative stress and disrupting their vicious cycle,thereby providing a theoretical foundation for expanding TCM treatment strategies and mechanistic research on KOA.

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(收稿日期:2025-11-27)

备注/Memo

备注/Memo:
基金项目:国家中医药管理局2018年全国名老中医药专家传承工作室建设项目(国中医药人教函〔2018〕134号)
长安医学关中李氏骨伤学术流派传承工作室建设项目(陕中医药发〔2018〕40号)
陕西省教育厅科研项目(陕教函〔2025〕96号)
△通信作者 E-mail:spine_surgeon@163.com
更新日期/Last Update: 2026-08-15