[1]王凯韬,李志伟,金杰,等.系统性免疫炎症指数与骨质疏松症的相关性研究[J].中国中医骨伤科杂志,2024,32(05):46-49.[doi:10.20085/j.cnki.issn1005-0205.240509]
　WANG Kaitao,LI Zhiwei,JIN Jie,et al.Study on the Correlation between Systemic Immune-Inflammation Index and Osteoporosis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2024,32(05):46-49.[doi:10.20085/j.cnki.issn1005-0205.240509]
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系统性免疫炎症指数与骨质疏松症的相关性研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第32卷
期数:
2024年05期
页码:
46-49
栏目:
临床研究
出版日期:
2024-05-05

文章信息/Info

Title:
Study on the Correlation between Systemic Immune-Inflammation Index and Osteoporosis
文章编号:
1005-0205(2024)05-0046-04
作者:
王凯韬1; 李志伟2; 金杰2; 王建伟3△
1南京中医药大学(南京,210023)
2南京中医药大学第二附属医院
3无锡市中医院
Author(s):
WANG Kaitao1; LI Zhiwei2; JIN Jie2; WANG Jianwei3△
1Nanjing University of Chinese Medicine,Nanjing 210023,China; 2Second Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210017,China; 3Wuxi Hospital of Traditional Chinese Medicine,Wuxi 214071,Jiangsu China.
关键词:
系统性免疫炎症指数;  骨质疏松症;  骨密度;  炎症;  血常规
Keywords:
systemic immune-inflammation index;  osteoporosis;  bone mineral density;  inflammation;  blood routine examination
分类号:
R68
DOI:
10.20085/j.cnki.issn1005-0205.240509
文献标志码:
A
摘要:
目的:系统性免疫炎症指数(SII)是一项能够反映人体炎症和免疫状态的指标,本研究旨在探讨系统性免疫炎症指数与骨密度(BMD)的相关性,以及将系统性免疫炎症指数应用于骨质疏松症诊断的可行性。方法:回顾性分析2023年1月至2023年10月进行血常规检查及骨密度检查,并且符合纳入标准的272名患者,采集患者血小板计数、中性粒细胞计数及淋巴细胞计数,计算出系统性免疫炎症指数,并根据患者的骨密度T值分为骨质疏松症组和非骨质疏松症组。采用二元Logistic回归分析探讨系统性免疫炎症指数与骨质疏松症的关系,采用Spearman等级相关分析探讨系统性免疫炎症指数与骨密度的关系,采用受试者工作特征(ROC)曲线分析系统性免疫炎症指数诊断骨质疏松症的能力及诊断最佳临界值。结果:系统性免疫炎症指数与骨质疏松症的发生显著相关,差异有统计学意义(P<0.001),骨质疏松症患者的系统性免疫炎症指数显著高于非骨质疏松症患者,差异有统计学意义(P<0.001); 系统性免疫炎症指数与骨密度显著相关,差异有统计学意义(L1～L5,r=0.425,P<0.001; 股骨颈,r=0.363,P<0.001); 受试者工作特征曲线分析表明系统性免疫炎症指数对骨质疏松症的诊断具有中等准确性(曲线下面积为0.787); 此外,系统性免疫炎症指数预测骨质疏松症风险的最佳临界值为613.03。结论:在50岁以上人群中,系统性免疫炎症指数值与骨密度呈负相关,当系统性免疫炎症指数值高于613.03时,患者有较高风险患骨质疏松症。
Abstract:
Objective:Systemic immune-inflammation index can reflect the inflammatory and immune state of the body.This study aims to explore the correlation between systemic immune-inflammation index(SII)and bone mineral density(BMD),and if this index can be used to diagnose osteoporosis.Methods:272 patients with blood routine examination and BMD measurement from January 2023 to October 2023 were prospectively analyzed.Platelet counts,neutrophil counts,and lymphocyte counts were collected to calculate SII.Binary logistic regression and receiver operating characteristic(ROC)curve analysis was used to analysis the correlation between SII and osteoporosis and the optimal cut-off value.Spearman grade correlation was used to explore the link between BMD and SII.Results:SII is significantly related to the osteoporosis(P<0.001).The SII of patients with osteoporosis was significantly higher than that of patients without osteoporosis(P<0.001).SII is significantly related to BMD(L1-L5,r=0.425,P<0.001; femora neck,r=0.363,P<0.001).ROC curve showed the diagnostic accuracy(area under curve(AUC)=0.787)and the optimal cut-off value(613.03).Conclusion:SII shows a negative correlation with BMD in people over 50 years old.Patients have a higher risk of osteoporosis when SII is higher than 613.03.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(82274546)
△通信作者 E-mail:wxzy006@njucm.edu.cn
更新日期/Last Update: 2024-05-15