[1]夏雪,沈霖△,凌家艳,等.加味阳和汤治疗寒湿痹阻型膝骨关节炎的疗效及对炎症因子的影响[J].中国中医骨伤科杂志,2024,32(03):55-58.[doi:10.20085/j.cnki.issn1005-0205.240311]
　XIA Xue,SHEN Lin,LING Jiayan,et al.The Therapeutic Efficacy of Modified Yanghe Decoction on Knee Osteoarthritis of Cold Dampness Obstruction Type and Its Impact on Inflammatory Factors[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2024,32(03):55-58.[doi:10.20085/j.cnki.issn1005-0205.240311]
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加味阳和汤治疗寒湿痹阻型膝骨关节炎的疗效及对炎症因子的影响()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第32卷
期数:
2024年03期
页码:
55-58
栏目:
临床研究
出版日期:
2024-03-15

文章信息/Info

Title:
The Therapeutic Efficacy of Modified Yanghe Decoction on Knee Osteoarthritis of Cold Dampness Obstruction Type and Its Impact on Inflammatory Factors
文章编号:
1005-0205(2024)03-0055-04
作者:
夏雪1; 沈霖2△; 凌家艳1; 帅波2
1武汉市中西医结合医院(武汉,430030)
2华中科技大学同济医学院附属协和医院
Author(s):
XIA Xue1; SHEN Lin2△; LING Jiayan1; SHUAI Bo2
1Wuhan Integrated Hospital of Traditional Chinese and Western Medicine,Wuhan 430030,China; 2Wuhan Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China.
关键词:
膝骨关节炎;  炎症因子;  阳和汤;  软骨损伤
Keywords:
knee osteoarthritis;  inflammatory factors;  Yanghe decoction;  cartilage damage
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.240311
文献标志码:
A
摘要:
目的:探讨加味阳和汤治疗寒湿痹阻型膝骨关节炎(KOA)患者的临床疗效及对炎症因子的影响。方法:选取膝骨关节炎患者90例,按随机数字表法分为观察组和对照组各45例。观察组采用加味阳和汤治疗,对照组采用塞来昔布治疗,治疗4周,观察治疗前后两组患者视觉模拟量表(VAS)评分、中医症候积分、西安大略和麦克马斯特大学(WOMAC)骨关节炎指数水平及炎症因子的变化。结果:治疗前两组患者VAS评分、中医症候积分及WOMAC指数水平比较,差异无统计学意义(P>0.05); 与对照组比较,治疗后观察组VAS评分、中医症候积分及WOMAC指数水平明显降低,差异有统计学意义(P<0.05); 治疗前两组患者炎症因子水平比较,差异无统计学意义(P>0.05); 与对照组比较,治疗后观察组IL-1、IL-6、TNF-α、MMP-3及MMP-9显著下降,差异有统计学意义(P<0.01)。结论:加味阳和汤能缓解寒湿痹阻型膝骨关节炎患者临床症状,改善患者的膝关节功能,促进关节功能恢复,从而治疗膝骨关节炎,其机制可能与降低炎症因子IL-1、IL-6及TNF-α,减轻关节炎症反应,下调MMP-3、MMP-9的水平,减轻软骨损伤有关。
Abstract:
Objective:To explore the clinical efficacy of modified Yanghe decoction on the treatment of knee osteoarthritis(KOA)patients with cold dampness obstruction and its impact on inflammatory factors.Methods:90 patients with KOA were selected and randomly divided into an observation group of 45 cases and a control group of 45 cases by using random number table method.The observation group was treated with modified Yanghe decoction combined with celecoxib,while the control group was treated with celecoxib for 4 weeks.The changes in visual analogue scale(VAS)scores,traditional Chinese medicine(TCM)symptom scores,Western Ontario and McMaster Universities(WOMAC)levels,and inflammatory factors were observed before and after treatment in both groups of patients.Results:There was no statistically significant difference(P>0.05)in VAS scores,TCM syndrome scores,and WOMAC levels between the two groups of patients before treatment.Compared with the control group,the VAS scores,TCM syndrome scores,and WOMAC levels in the observation group decreased significantly after treatment,with a statistically significant difference(P<0.05).There was no statistically significant difference(P>0.05)in the levels of inflammatory factors between the two groups of patients before treatment.Compared with the control group,the observation group had IL-1,IL-6,TNF-α levels after treatment,MMP-3 and MMP-9 significantly decreased,with statistically significant differences(P<0.01).Conclusion:Modified Yanghe decoction can effectively alleviate the clinical symptoms of KOA patients with cold dampness obstruction type,improve knee joint function,promote joint function recovery,and treat KOA.Its mechanism may be related to the reduction of inflammatory factors IL-1,IL-6,and TNF-α reducing joint inflammatory response and downregulating the levels of MMP-3 and MMP-9 are related to reducing cartilage damage.

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备注/Memo

备注/Memo:
基金项目:中央高校基本科研业务费专项基金项目(2019kfyRCPY093)
武汉市卫健委课题项目(WZ16A05)
△通信作者 E-mail:shenlinhb@sina.cn
更新日期/Last Update: 2024-03-15