[1]叶灵山,华臻,李绍烁,等.抗骨质疏松药物对骨折愈合的影响[J].中国中医骨伤科杂志,2023,31(07):78-84.[doi:10.20085/j.cnki.issn1005-0205.230716 ]
点击复制

抗骨质疏松药物对骨折愈合的影响()
分享到:

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第31卷
期数:
2023年07期
页码:
78-84
栏目:
文献综述
出版日期:
2023-07-15

文章信息/Info

文章编号:
1005-0205(2023)07-0078-07
作者:
叶灵山1华臻2李绍烁2王建伟2△
1南京中医药大学(南京,210023)
2南京中医药大学无锡附属医院
关键词:
骨质疏松症 骨折愈合 抗骨质疏松药
分类号:
R683
DOI:
10.20085/j.cnki.issn1005-0205.230716
文献标志码:
A

参考文献/References:

[1] American association of clinical endocrinologists,American college of endocrinology.Clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update[J].Endocr Pract,2020,26(Suppl 1):1-46.
[2] MURPHY C M,SCHINDELER A,CANTRILL L C,et al.PTH(1-34)treatment increases bisphosphonate turnover in fracture repair in rats[J].J Bone Miner Res,2015,30(6):1022-1029.
[3] AYDOGAN N H,ÖZEL I,ILTAR S,et al.The effect of vitamin D and bisphosphonate on fracture healing:an experimental study[J].J Clin Orthop Trauma,2016,7(2):90-94.
[4] MENZDORF L,WEUSTER M,KLÜTER T,et al.Local pamidronate influences fracture healing in a rodent femur fracture model:an experimental study[J].BMC Musculoskelet Disord,2016,17:255.
[5] CHAPURLAT R D,PALERMO L,RAMSAY P,et al.Risk of fracture among women who lose bone density during treatment with alendronate:the fracture intervention trial[J].Osteoporosis International,2005,16(7):842-848.
[6] REBOLLEDO B J,UNNANUNTANA A,LANE J M.A comprehensive approach to fragility fractures[J].Journal of Orthopaedic Trauma,2011,25(9):566-573.
[7] VAN DER POEST CLEMENT E,PATKA P,VANDORMAEL K,et al.The effect of alendronate on bone mass after distal forearm fracture[J].Journal of Bone and Mineral Research,2000,15(3):586-593.
[8] DUCKWORTH A D,MCQUEEN M M,TUCK C E,et al.Effect of alendronic acid on fracture healing:a multicenter randomized placebo controlled trial[J].Journal of Bone and Mineral Research,2019,34(6):1025-1032.
[9] GONG H S,SONG C H,LEE Y H,et al.Early initiation of bisphosphonate does not affect healing and outcomes of volar plate fixation of osteoporotic distal radial fractures[J].J Bone Joint Surg,2012,94(19):1729-1736.
[10] UCHIYAMA S,ITSUBO T,NAKAMURA K,et al.Effect of early administration of alendronate after surgery for distal radial fragility fracture on radiological fracture healing time[J].Bone Joint Surgery,2013,95-B(11):1544-1550.
[11] HEGDE V,JO J E,ANDREOPOULOU P,et al.Effect of osteoporosis medications on fracture healing[J].Osteoporosis Int,2016,27(3):861-871.
[12] AMANAT N,MCDONALD M,GODFREY C,et al.Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair[J].Journal of Bone & Mineral Research,2010,22(6):867-876.
[13] MCDONALD M M,DULAI S,GODFREY C,et al.Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling[J].Bone,2008,43(4):653-662.
[14] KURTH A,EBERHARDT C,MÜLLER S,et al.The bisphosphonate ibandronate improves implant integration in osteopenic ovariectomized rats[J].Bone,2005,37(2):204-210.
[15] CHEN B,LI Y,YANG X,et al.Zoledronic acid enhances bone-implant osseointegration more than alendronate and strontium ranelate in ovariectomized rats[J].Osteoporosis Int,2013,24(7):2115-2121.
[16] SKRIPITZ R,JOHANSSON H R,ULRICH S D,et al.Effect of alendronate and intermittent parathyroid hormone on implant fixation in ovariectomized rats[J].Journal of Orthopaedic Science,2009,14(2):138-143.
[17] CHEN B L,XIE D H,ZHENG Z M,et al.Comparison of the effects of alendronate sodium and calcitonin on bone-prosthesis osseointegration in osteoporotic rats[J].Osteoporos Int,2011,22(1):265-270.
[18] VIERA-NEGRN Y E,RUAN W H,WINGER J N,et al.Effect of ovariectomy and alendronate on implant osseointegration in rat maxillary bone[J].J Oral Implantol,2008,34(2):76-82.
[19] QI M,HU J,LI J,et al.Effect of zoledronate acid treatment on osseointegration and fixation of implants in autologous iliac bone grafts in ovariectomized rabbits[J].Bone,2012,50(1):119-127.
[20] TSETSENEKOU E,PAPADOPOULOS T,KALYVAS D,et al.The influence of alendronate on osseointegration of nanotreated dental implants in New Zealand rabbits[J].Clinical Oral Implants Research,2012,23(6):659-666.
[21] YILDIZ A,ESEN E,KURKCU M,et al.Effect of zoledronic acid on osseointegration of titanium implants:an experimental study in an ovariectomized rabbit model[J].Journal of Oral and Maxillofacial Surgery,2010,68(3):515-523.
[22] LIN T,YAN S G,CAI X Z,et al.Bisphosphonates for periprosthetic bone loss after joint arthroplasty:a meta-analysis of 14 randomized controlled trials[J].Osteoporosis Int,2012,23(6):1823-1834.
[23] LARSEN M S,SCHMAL H.The enigma of atypical femoral fractures:a summary of current knowledge[J].EFORT Open Reviews,2018,3(9):494-500.
[24] LIN S J,YEO I,YOON P W,et al.Incidence,risk factors,and fracture healing of atypical femoral fractures:a multicenter case-control study[J].Osteoporosis Int,2018,29(11):2427-2435.
[25] HA K,PARK K,KIM S,et al.Does bisphosphonate-based anti-osteoporosis medication affect osteoporotic spinal fracture healing?[J].Osteoporosis Int,2015,27(2):1-6.
[26] GERSTENFELD L C,SACKS D J,PELIS M,et al.Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing[J].Journal of Bone and Mineral Research,2009,24(2):196-208.
[27] FLICK L M,WEAVER J M,ULRICH-VINTHER M,et al.Effects of receptor activator of NF-κB(RANK)signaling blockade on fracture healing[J].Journal of Orthopaedic Research,2010,21(4):676-684.
[28] CUMMINGS S R,SAN MARTIN J,MCCLUNG M R,et al.Denosumab for prevention of fractures in postmenopausal women with osteoporosis[J].N Engl J Med,2009,361(8):756-765.
[29] ADAMI S,LIBANATI C,BOONEN S,et al.Denosumab treatment in postmenopausal women with osteoporosis does not interfere with fracture-healing:results from the FREEDOM trial[J].J Bone Joint Surg Am,2012,94(23):2113-2119.
[30] BILEZIKIAN J P,LIN C J F,BROWN J P,et al.Long-term denosumab treatment restores cortical bone loss and reduces fracture risk at the forearm and humerus:analyses from the FREEDOM extension cross-over group[J].Osteoporos Int,2019,30(9):1855-1864
[31] MILLER P D,PANNACCIULLI N,BROWN J P,et al.Denosumab or zoledronic acid in postmenopausal women with osteoporosis previously treated with oral bisphosphonates[J].J Clin Endocrinol Metab,2016,101(8):3163-3170.
[32] ZEBAZE R,LIBANATI C,MCCLUNG M R,et al.Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis[J].J Bone Miner Res,2016,31(10):1827-1834
[33] KENDLER D L,ROUX C,BENHAMOU C L,et al.Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy[J].J Bone Miner Res,2010,25(1):72-81.
[34] BEKKER P J,HOLLOWAY D L,RASMUSSEN A S,et al.A single-dose placebo-controlled study of AMG 162,a fully human monoclonal antibody to RANKL,in postmenopausal women[J].J Bone Miner Res,2004,19(7):1059-1066.
[35] BROWN J P,PRINCE R L,DEAL C,et al.Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass:a randomized,blinded,phase 3 trial[J].J Bone Miner Res,2009,24(1):153-161.
[36] MILLER P D,BOLOGNESE M A,LEWIECKI E M,et al.Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued,discontinued,and restarting of therapy:a randomized blinded phase 2 clinical trial1[J].Bone,2008,43(2):222-229.
[37] ADAMI S,ADACHI J,BOONEN S,et al.Denosumab administration is not associated with fracture healing complications in postmenopausal women with osteoporosis:results from the FREEDOM trial[J].J Bone Miner Res,2010,25(Suppl 1):MO0405.
[38] MOEN M D,KEAM S J.Denosumab:a review of its use in the treatment of postmenopausal osteoporosis[J].Drugs & Aging,2011,28(1):63-82.
[39] ADAMI S,LIBANATI C,BOONEN S,et al.Denosumab treatment in postmenopausal women with osteoporosis does not interfere with fracture-healing:results from the FREEDOM trial[J].J Bone Joint Surg Am,2012,94(23):2113-2119.
[40] ANDREASSEN T T,EJERSTED C,OXLUND H.Intermittent parathyroid hormone(1-34)treatment increases callus formation and mechanical strength of healing rat fractures[J].Journal of Bone & Mineral Research,2010,14(6):960-968.
[41] ANDREASSEN T T,WILLICK G E,MORLEY P,et al.Treatment with parathyroid hormone hPTH(1-34),hPTH(1-31),and monocyclic hPTH(1-31)enhances fracture strength and callus amount after withdrawal fracture strength and callus mechanical quality continue to increase[J].Calcified Tissue International,2004,74(4):351-356.
[42] ALKHIARY Y M,GERSTENFELD L C,KRALL E,et al.Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone(PTH 1-34)[J].Journal of Bone & Joint Surgery:American Volume,2005,87(4):731-741.
[43] MANABE T,MORI S,MASHIBA T,et al.Human parathyroid hormone(1-34)accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys[J].Bone,2007,40(6):1475-1482.
[44] KOMATSUBARA S,MORI S,MASHIBA T,et al.Human parathyroid hormone(1-34)accelerates the fracture healing process of woven to lamellar bone replacementand new cortical shell formation in rat femora[J].Bone,2005,36(4):678-687.
[45] FRIEDL G,TURNER R T,EVANS G L,et al.Intermittent parathyroid hormone(PTH)treatment and age-dependent effects on rat cancellous bone and mineral metabolism[J].J Orthop Res,2007,25(11):1454-1464.
[46] TINSLEY B A,DUKAS A,PENSAK M J,et al.Systemic administration of sclerostin antibody enhances bone morphogenetic protein-induced femoral defect repair in a rat model[J].Journal of Bone & Joint Surgery:American Volume,2015,97(22):1852-1859.
[47] O'LOUGHLIN P F,CUNNINGHAM M E,BUKATA S V,et al.Parathyroid hormone(1-34)augments spinal fusion,fusion mass volume,and fusion mass quality in a rabbit spinal fusion model[J].Spine,2008,34(2):121-130.
[48] BERNHARDSSON M,ASPENBERG P.Abaloparatide versus teriparatide:a head to head comparison of effects on fracture healing in mouse models[J].Acta Orthop,2018,89:674-677.
[49] LANSKE B,CHANDLER H,PIERCE A,et al.Abaloparatide,a PTH receptor agonist with homology to PTHrP,enhances callus bridging and biomechanical properties in rats with femoral fracture[J].J Orthop Res,2018,37(4):812-820.
[50] KENDLER D L,MARIN F,ZERBINI C A F,et al.Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis(VERO):a multicentre,doubleblind,double-dummy,randomised controlled trial[J].Lancet,2018,391(10117):230-240.
[51] DÍEZ-PÉREZ A,MARIN F,ERIKSON E F,et al.Effects of teriparatide on hip and upper limb fractures in patients with osteoporosis:a systematic review and meta-analysis[J].Bone,2019,120:1-8.
[52] REYNOLDS D G,SHAIKH S,PAPUGA M O,et al.MuCT-based measurement of cortical bone graft-to-host union[J].J Bone Miner Res,2009,24(5):899-907.
[53] RUBERY P T,BUKATA S V.Teriparatide may accelerate healing in delayed unions oftype Ⅲ odontoid fractures:a report of 3 cases[J].J Spinal Disord Tech,2010,23(2):151-155.
[54] BUKATA S V,PUZAS J E.Orthopedic uses ofteriparatide[J].Curr Osteoporos Rep,2010,8(1):28-33.
[55] ASPENBERG P,GENANT H K,JOHANSSON T,et al.Teriparatide for acceleration of fracture repair in humans:a prospective,randomized,double-blind study of 102 postmenopausal women with distal radial fractures[J].J Bone Miner Res,2010,25(2):404-414.
[56] ASPENBERG P,JOHANSSON T.Teriparatide improves early callus formation in distal radial fractures[J].Acta Orthop,2010,81(2):234-236.
[57] PEICHL P,HOLZER L A,MAIER R,et al.Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women[J].J Bone Joint Surg Am,2011,93(17):1583-1587.
[58] OHTORI S,INOUE G,ORITA S,et al.Teriparatide accelerates lumbar posterolateral fusion in women with postmenopausal osteoporosis[J].Spine(Phila Pa 1976),2012,37(23):E1464-E1468.
[59] OHTORI S,INOUE G,ORITA S,et al.Comparison of teriparatide and bisphosphonate treatment to reduce pedicle screw loosening after lumbar spinal fusion surgery in postmenopausal women with osteoporosis from a bone quality perspective[J].Spine(Phila Pa 1976),2013,38(8):E487-E492.
[60] MIN H K,AHN J H,HA K Y,et al.Effects of anti-osteoporosis medications on radiological and clinical results after acute osteoporotic spinal fractures:a retrospective analysis of prospectively designed study[J].Osteoporos Int,2019,30(11):2249-2256.
[61] LOU S,LV H,WANG G,et al.The effect of teriparatide on fracture healing of osteoporotic patients:a meta-analysis of randomized controlled trials[J].Biomed Res Int,2016:6040379.
[62] HAN S,WEN S M,ZHAO Q P,et al.The efficacy of teriparatide in improving fracture healing in hip fractures:a systematic review and meta-analysis[J].BioMed Research International,2020:5914502.
[63] EASTMAN K,GERLACH M,PIEC I,et al.Effectiveness of parathyroid hormone(PTH)analogues on fracture healing:a meta-analysis[J].Osteoporos Int,2021,32(8):1531-1546.
[64] HA Y C,PARK Y G,NAM K W,et al.Trend in hip fracture incidence and mortality in Korea:a prospective cohort study from 2002 to 2011[J].J Korean Med Sci,2015,30(4):483-488.
[65] ASPENBERG P,MALOUFJ,TARANTINO U,et al.Effects of teriparatide compared with risedronate on recovery after pertrochanteric hip fracture:results of a randomized,active-controlled,double-blind clinical trial at 26 weeks[J].J BoneJoint Surg Am,2016,98(22):1868-1878.
[66] HUANG T W,CHUANG P Y,LIN S J,et al.Teriparatide improves fracture healing and early functional recovery in treatment of osteoporotic intertrochanteric fractures[J].Medicine(Baltimore),2016,95(19):e3626.
[67] ASPENBERG P,GENANT H K,JOHANSSON T,et al.Teriparatide for acceleration of fracture repair in humans:a prospective,randomized,double-blind study of 102 postmenopausal women with distal radial fractures[J].J Bone Miner Res,2010,25(2):404-414.
[68] KIM S J,PARK H S,LEE D W,et al.Short-term daily teriparatide improve postoperative functional outcome and fracture healing in unstable intertrochanteric fractures[J].Injury,2019,50(7):1364-1370.
[69] JOHANSSON T.PTH 1-34(teriparatide)may not improve healing in proximal humerus fractures:a randomized,controlled study of 40 patients[J].Acta Orthop,2016,87(1):79-82.
[70] SPIRO A S,KHADEM S,JESCHKE A,et al.The SERM raloxifene improves diaphyseal fracture healing in mice[J].J Bone Miner Metab,2013,31(6):629-636.
[71] STUERMER E K,SEHMISCH S,RACK T,et al.Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis:a new fracture-healing model at the tibia in rat[J].Langenbecks Arch Surg,2010,395(2):163-172.
[72] LEIBLEIN M,HENRICH D,FERVERS F,et al.Do antiosteoporotic drugs improve bone regeneration in vivo?[J].Eur J Trauma Emerg Surg,2020,46(2):287-299.
[73] CAO Y P,MORI S,MASHIBA T,et al.Raloxifene,estrogen,and alendronate affect the processes of fracture repair differently in ovariectomized rats[J].Journal of Bone & Mineral Research,2002,17(12):2237-2246.
[74] BEIL F T,BARVENCIK F,GEBAUER M,et al.Effects of estrogen on fracture healing in mice[J].Journal of Trauma,2010,69(5):1259-1265.
[75] RAMALHO-FERREIRA G,FAVERANI L P,PRADO F B,et al.Raloxifene enhances peri-implant bone healing in osteoporotic rats[J].International Journal of Oral and Maxillofacial Surgery,2015,44(6):798-805.
[76] CAO Y,MORI S,MASHIBA T,et al.Raloxifene,estrogen,and alendronate affect the processes of fracture repair differently in ovariectomized rats[J].J Bone Miner Res,2002,17(12):2237-2246.
[77] ETTINGER B,BLACK D M,MITLAK B H,et al.Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene:results from a 3-year randomized clinical trial:multiple outcomes of raloxifene evaluation(MORE)investigators[J].J Am Med Assoc,1999,282(7):637-645.
[78] BARON R,KNEISSEL M.WNT signaling in bone homeostasis and disease:from human mutations to treatments[J].Nat Med,2013,19(2):179-192.
[79] FARHANG A,VIRK M S,TANG H,et al.Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model[J].Journal of Orthopaedic Research,2013,32(2):197-203.
[80] OMINSKY M S,BROWN D L,VAN G,et al.Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats[J].Bone,2015,81:380-391.
[81] BANDEIRA L,LEWIECKI E M,BILEZIKIAN J P.Romosozumab for the treatment of osteoporosis[J].Expert Opinion on Biological Therapy,2017,17(2):255.
[82] COSMAN F,CRITTENDEN D B,TERRARI S,et al.FRAME study:the foundation effect of building bone with 1 year of romosozumab leads to continued lower fracture risk after transition to denosumab[J].J Bone Miner Res,2018,33(7):1219-1226.
[83] CHRISTIAN G,CAMPBELL G M,PENA J,et al.Administration of romosozumab improves vertebral trabecular and cortical bone as assessed with quantitative computed tomography and finite element analysis[J].Bone,2015,81:364-369.
[84] SAAG K G,PETERSEN J,BRANDI M L,et al.Romosozumab or alendronate for fracture prevention in women with osteoporosis[J].N Engl J Med,2017,377(15):1417-1427.
[85] KOCIJAN R,KLAUSHOFER K,MISOF B M.Osteoporosis therapeutics 2020[J].Handb Exp Pharmacol,2020,262:397-422.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(81873320,82274546,82205142)
无锡市“双百”中青年医疗卫生拔尖人才项目(HB2020063)
通信作者 E-mail:wangjianwei1963@126.com
更新日期/Last Update: 2023-07-10