[1]吴亚东△ 齐晓艳 鲁玉州 秦东 杨晓旭 王金国 梁博成 史晓林.仲黄颗粒对老年骨质疏松椎体压缩性骨折术后骨转换标志物及生活质量的影响[J].中国中医骨伤科杂志,2022,30(08):46-50+55.
　WU Yadong QI Xiaoyan LU Yuzhou QIN Dong YANG Xiaoxu WANG Jinguo LIANG Bocheng SHI Xiaolin.Efficacy of Bone Turnover Marker and Quality of Life of Zhong Huang Granule on the Treatment of Senile Osteoporotic Vertebral Compression Fracture after Operation[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2022,30(08):46-50+55.
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仲黄颗粒对老年骨质疏松椎体压缩性骨折术后骨转换标志物及生活质量的影响()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第30卷
期数:
2022年08期
页码:
46-50+55
栏目:
临床研究
出版日期:
2022-08-15

文章信息/Info

Title:
Efficacy of Bone Turnover Marker and Quality of Life of Zhong Huang Granule on the Treatment of Senile Osteoporotic Vertebral Compression Fracture after Operation
文章编号:
1005-0205(2022)08-0046-05
作者:
吴亚东1△ 齐晓艳2 鲁玉州1 秦东1 杨晓旭1 王金国1 梁博成3 史晓林3
1山东中医药大学附属日照市中医医院(山东 日照,276800) 2山东日照市人民医院 3浙江中医药大学第二附属医院
Author(s):
WU Yadong1△ QI Xiaoyan2 LU Yuzhou1 QIN Dong1 YANG Xiaoxu1 WANG Jinguo1 LIANG Bocheng3 SHI Xiaolin3
1Rizhao Hospital of Traditional Chinese Medicine Affiliated to Shandong University of Traditional Chinese Medicine,Rizhao 276800,Shandong China; 2People's Hospital of Rizhao,Rizhao 276826,Shandong China; 3The Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,China.
关键词:
老年性骨质疏松椎体压缩性骨折;  仲黄颗粒;  生活质量分析;  骨转换标志物
Keywords:
senile osteoporotic vertebral compression fracture;  Zhong Huang granule;  quality of life analysis;  bone turnover markers
分类号:
R274.9
文献标志码:
A
摘要:
目的:探讨仲黄颗粒对老年性骨质疏松椎体压缩性骨折(Osteoporotic Vertebral Compression Fracture,OVCF)椎体成形术后患者骨转换标志物及生活质量(Quality of Life,QOL)的影响。方法:选取自2017年1月至2019年12月,在本院诊疗行椎体(后凸)成形术的老年性OVCF患者90例,随机分为治疗组和对照组(治疗组采用仲黄颗粒治疗,对照组采用仙灵骨葆治疗)。疗程均为6个月,观察骨密度、疼痛视觉模拟评分(VAS)、血清Ⅰ型原胶原氨基端前肽(PINP)、血清骨钙素(OST)、血清β-胶联降解产物(β-CTx)、生活质量问卷(QUALEFFO-41量表)评分变化。结果:治疗组和对照组分别有41例和38例患者获得随访,两组患者对临床疗效均较为满意。对比治疗前,两组患者骨密度、VAS评分、PINP、QUALEFFO-41量表评分及治疗组OST、β-CTx均显著改善,差异有统计学意义(P<0.05); 对比对照组,治疗组6个月VAS评分和PINP改善更为明显,组间差异有统计学意义(P<0.05)。结论:仲黄颗粒和仙灵骨葆均可以提高老年OVCF术后患者骨密度、减轻腰背疼痛、改善生活质量,与仙灵骨葆相比,仲黄颗粒能更有效缓解疼痛、调节骨代谢和促进成骨作用。
Abstract:
Objective:To observe the efficacy of bone turnover marker and quality of life(QOL)of Zhong Huang granule on the treatment of senile OVCF(osteoporotic vertebral compression fracture)with postoperative vertebroplasty.Methods:90 cases with senile OVCF treated by postoperative vertebroplasty were selected and randomed into treatment group and control group from January 2017 to December 2019.Patients on the treatment group were treated by Zhong Huang granule,in the control group,patients were treated by Xianling Gubao.Bone mineral density,VAS scores,aminoterminal prepeptide typeⅠprocollagen(PINP),serum osteocalcin(OST),β-C-terminal telopeptide of type Ⅰ collagen(β-CTx),and QUALEFFO-41 were observed and recorded before and 6 months after treatment.Results:41 patients in the treatment group were followed up,and 38 patients in the control group were followed up.Satisfactory clinical efficacy was achieved in both groups.Bone mineral density,VAS scores,PINP,QUALEFFO-41 scores in both groups,and OST,β-CTx on the treatment group were significantly improved after treating(P<0.05).The VAS scores and PINP in the treatment group were significantly improved compared with the control group(P<0.05).Conclusion:Both Zhong Huang granule and Xianling Gubao can improve bone density,relieve back pain and improve the living quality.Zhong Huang granule can relieve pain,regulate bone metabolism and promote osteogenesis more effectively than Xianling Gubao granule.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年科学基金项目(81803902)
山东省中医药科技发展计划项目(2019-0805)
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更新日期/Last Update: 2022-08-15