[1]王世海△ 武晔.膝骨关节炎患者血清基因表达水平与病情程度的关系[J].中国中医骨伤科杂志,2022,30(08):32-35.
　WANG Shihai WU Ye.Relationship between Serum miR-212-5p Level and Disease Severity in Patients with Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2022,30(08):32-35.
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膝骨关节炎患者血清基因表达水平与病情程度的关系()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第30卷
期数:
2022年08期
页码:
32-35
栏目:
临床研究
出版日期:
2022-08-15

文章信息/Info

Title:
Relationship between Serum miR-212-5p Level and Disease Severity in Patients with Knee Osteoarthritis
文章编号:
1005-0205(2022)08-0032-04
作者:
王世海1△ 武晔1
1河北沧州中西医结合医院(河北 沧州,061000)
Author(s):
WANG Shihai1△ WU Ye1
1Hebei Cangzhou integrated traditional Chinese and Western Medicine Hospital,Cangzhou 061000,Hebei China.
关键词:
膝骨关节炎;  微小核糖核酸-212-5p;  病情严重程度;  炎性细胞因子;  相关性
Keywords:
knee osteoarthritis;  microRNA-212-5p;  severity of illness;  inflammatory cytokines;  relevance
分类号:
R684.3
文献标志码:
A
摘要:
目的:探讨膝骨关节炎(KOA)患者血清微小核糖核酸-212-5p(miR-212-5p)表达水平与病情严重程度的关系。方法:选取152例KOA患者(治疗组)及同期147例健康志愿者(对照组),均检测血清miR-212-5p及促炎症因子(IL-1β、IL-6、TNF-α)水平。结果:治疗组促炎症因子水平高于对照组,差异有统计学意义(P<0.05),miR-212-5p低于对照组,差异有统计学意义(P<0.05); 炎性因子在轻、中、重度KOA患者中依次升高,差异有统计学意义(P<0.05),miR-212-5p依次降低,差异有统计学意义(P<0.05); KOA患者血清miR-212-5p与促炎症因子水平负相关,差异有统计学意义(P<0.05); 促炎症因子、miR-212-5p均是KOA病情加重的影响因素,差异有统计学意义(P<0.05)。结论:KOA患者血清miR-212-5p表达水平降低,可作为评估KOA病情严重程度的辅助指标。
Abstract:
Objective:To investigate the relationship between the expression level of serum microRNA-212-5p(miR-212-5p)and the severity of knee osteoarthritis(KOA).Methods:152 patients with KOA(treatment group)and 147 healthy volunteers(control group)in the same period were selected,and the serum levels of miR-212-5p and inflammatory factors(IL-1β,IL-6 and TNF-α)were detected.Results:The levels of inflammatory factors in the treatment group were higher than those in the control group(P<0.05)but miR-212-5p was lower than that in the control group(P<0.05).The inflammatory factors in patients with mild,moderate and severe KOA patients increased in turn(P<0.05),while miR-212-5p decreased in turn(P<0.05).The serum miR-212-5p in KOA patients was negatively correlated with the levels of inflammatory factors(P<0.05).Inflammatory factors and miR-212-5p were the influencing factors for exacerbation of KOA(P<0.05).Conclusion:The expression level of serum miR-212-5p is decreased in patients with KOA,which can be used as an auxiliary index to evaluate the severity of KOA.

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备注/Memo

备注/Memo:
基金项目:沧州市重点研发计划指导项目(204106028)
△通信作者 E-mail:wsh1988w@163.com
更新日期/Last Update: 2022-08-15