参考文献/References:
[1] CHAVALI M,ULLOA-NAVAS M J,PéREZ-BORREDá P,et al.Wnt-dependent oligodendroglial-endothelial interactions regulate white matter vascularization and attenuate injury[J].Neuron,2020,108(6):1130-1145.
[2] THAKUR A,SIDU R K,ZOU H,et al.Inhibition of glioma cells’ proliferation by doxorubicin-loaded exosomes via microfluidics[J].Int J Nanomedicine,2020,15:8331-8343.
[3] PASCUAL M,IBANEZ F,GUERRI C.Exosomes as mediators of neuron-glia communication in neuroinflammation[J].Neural Regen Res,2020,15(5):796-801.
[4] PETERSEN E D,ZENCHAK J R,LOSSIA O V,et al.Neural stem cells derived directly from adipose tissue[J].Stem Cells Dev,2018,27(9):637-647.
[5] ZAHR S K,KAPLAN D R,MILLER F D.Translating neural stem cells to neurons in the mammalian brain[J].Cell death and differentiation,2019,26(12):2495-2512.
[6] URBáN N,BLOMFIELD I M,GUILLEMOT F.Quiescence of adult mammalian neural stem cells:a highly regulated rest[J].Neuron,2019,104(5):834-848.
[7] SALUNKHE S,DHEERA J,BASAK M,et al.Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking:Strategies and significance[J].Journal of Controlled Release,2020,326:599-614.
[8] HU Y,RAO S S,WANG Z X,et al.Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function[J].Theranostics,2018,8(1):169-184.
[9] KOTAPATI S,PASSMORE D,YAMAZOE S,et al.Universal affinity capture liquid chromatography-mass spectrometry assay for evaluation of biotransformation of site-specific antibody drug conjugates in preclinical studies[J].Anal Chem,2020,92(2):2065-2073.
[10] TAYEBI M,ZHOU Y,TRIPATHI P,et al.Exosome purification and analysis using a facile microfluidic hydrodynamic trapping device[J].Analytical Chemistry(Washington),2020,92(15):10733-10742.
[11] ASGHAR S,LITHERLAND G J,LOCKHART J C,et al.Exosomes in intercellular communication and implications for osteoarthritis[J].Rheumatology(Oxford,England),2020,59(1):57-68.
[12] WU M,KARADOULAMA E,LLORET-LLINARES M,et al.The RNA exosome shapes the expression of key protein-coding genes[J].Nucleic Acids Res,2020,48(15):8509-8528.
[13] YANG D,ZHANG W,ZHANG H,et al.Progress,opportunity,and perspective on exosome isolation-efforts for efficient exosome-based theranostics[J].Theranostics,2020,10(8):3684-3707.
[14] KARNATI H K,GARCIA J H,TWEEDIE D,et al.Neuronal enriched extracellular vesicle proteins as biomarkers for traumatic brain injury[J].Journal of Neurotrauma,2019,36(7):975-987.
[15] SCHIAPPARELLI L M,SHARMA P,HE H Y,et al.Proteomic screen reveals diverse protein transport between connected neurons in the visual system[J].Cell Rep,2022,38(4):110287-110326.
[16] MANEK R,MOGHIEB A,YANG Z,et al.Protein biomarkers and neuroproteomics characterization of microvesicles/exosomes from human cerebrospinal fluid following traumatic brain injury[J].Mol Neurobiol,2018,55(7):6112-6128.
[17] YIN Z,HAN Z,HU T,et al.Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture[J].Brain Behav Immun,2020,83:270-282.
[18] ANGELOPOULOU E,PAUDEL Y N,SHAIKH M F,et al.Flotillin:a promising biomarker for alzheimer’s disease[J].J Pers Med,2020,10(2):20-32.
[19] SINHA M S,ANSELL-SCHULTZ A,CIVITELLI L,et al.Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers[J].Acta Neuropathologica,2018,136(1):41-56.
[20] YU Z,SHI M,STEWART T,et al.Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction[J].Brain,2020,143(6):1780-1797.
[21] XU B,ZHANG Y,DU X F,et al.Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity[J].Cell Res,2017,27(7):882-897.
[22] GHIDONI R,PATERLINI A,ALBERTINI V,et al.Cystatin C is released in association with exosomes:a new tool of neuronal communication which is unbalanced in Alzheimer’s disease[J].Neurobiology of Aging,2009,32(8):1435-1442.
[23] GOETZL E J,ABNER E L,JICHA G A,et al.Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease[J].FASEB J,2018,32(2):888-893.
[24] XITONG D,XIAORONG Z.Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases[J].Gene,2016,575(2,Part 2):377-384.
[25] LAHNE M,NAGASHIMA M,HYDE D R,et al.Reprogramming Muller Glia to regenerate retinal neurons[J].Annu Rev Vis Sci,2020,6:171-193.
[26] PAOLICELLI R C,BERGAMINI G,RAJENDRAN L.Cell-to-cell communication by extracellular vesicles:focus on microglia[J].Neuroscience,2019,405:148-157.
[27] MOREL L,REGAN M,HIGASHIMORI H,et al.Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1[J].Journal of Biological Chemistry,2013,288(10):7105-7116.
[28] FAURE J,LACHENAL G,COURT M,et al.Exosomes are released by cultured cortical neurones[J].Mol Cell Neurosci,2006,31(4):642-648.
[29] CHAUDHURI A D,DASTGHEYB R M,YOO S W,et al.TNF-α and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons[J].Cell Death Dis,2018,9(3):363-373.
[30] WANG G,WANG Y,LIU N,et al.The role of exosome lipids in central nervous system diseases[J].Rev Neurosci,2020,31(7):743-756.
[31] WOOD M J A,ALVAREZ-ERVITI L,SEOW Y,et al.Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes[J].Nature Biotechnology,2011,29(4):341-345.
[32] SEXTON R E,MPILLA G,KIM S,et al.Ras and exosome signaling[J].Semin Cancer Biol,2019,54:131-137.
[33] SEGURA E,AMIGORENA S,THéRY C.Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses[J].Blood Cells,Molecules,and Diseases,2005,35(2):89-93.
[34] VALADI H,EKSTROM K,BOSSIOS A,et al.Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J].Nat Cell Biol,2007,9(6):654-659.
[35] YANG B,DUAN W,WEI L,et al.Bone marrow mesenchymal stem cell-derived hepatocyte-like cell exosomes reduce hepatic ischemia/reperfusion injury by enhancing autophagy[J].Stem Cells Dev,2020,29(6):372-379.
[36] ZHAO S,LIU Y,PU Z.Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apoptosis by activating autophagy in vitro[J].Drug Des Devel Ther,2019,13:2887-2897.
[37] SUN W,LARSON M J,KIYOSHI C M,et al.Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury[J].J Clin Invest,2020,130(1):345-358.
[38] GONCALVES M B,MALMQVIST T,CLARKE E,et al.Neuronal RARβ signaling modulates PTEN activity directly in neurons and via exosome transfer in astrocytes to prevent glial scar formation and induce spinal cord regeneration[J].J Neurosci,2015,35(47):15731-15745.
[39] GONCALVES M B,WU Y,CLARKE E,et al.Regulation of myelination by exosome associated retinoic acid release from NG2-Positive cells[J].J Neurosci,2019,39(16):3013-3027.
[40] SAS A R,CARBAJAL K S,JEROME A D,et al.A new neutrophil subset promotes CNS neuron survival and axon regeneration[J].Nat Immunol,2020,21(12):1496-1505.
[41] KIYOSHI C,TEDESCHI A.Axon growth and synaptic function:a balancing act for axonal regeneration and neuronal circuit formation in CNS trauma and disease[J].Dev Neurobiol,2020,80(7-8):277-301.
[42] KONG F L,WANG X P,LI Y N,et al.The role of exosomes derived from cerebrospinal fluid of spinal cord injury in neuron proliferation in vitro[J].Artif Cells Nanomed Biotechnol,2018,46(1):200-205.
[43] WHEELER M A,CLARK I C,TJON E C,et al.MAFG-driven astrocytes promote CNS inflammation[J].Nature,2020,578(7796):593-599.
[44] GIOVANNONI F,QUINTANA F J.The role of astrocytes in CNS inflammation[J].Trends in Immunology,2020,41(9):805-819.
[45] SANMARCO L M,WHEELER M A,GUTIERREZ-VAZQUEZ C,et al.Gut-licensed IFNgamma(+)NK cells drive LAMP1(+)TRAIL(+)anti-inflammatory astrocytes[J].Nature,2021,590(7846):473-479.
[46] TSUNEMI T,ISHIGURO Y,YOROISAKA A,et al.Analysis of α-synuclein in exosomes[J].Methods in Molecular Biology(Clifton,N.J.),2021,2322:41-45.
[47] JIANG D,GONG F,GE X,et al.Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes[J].J Nanobiotechnology,2020,18(1):105-114.
[48] RUSSO M V,MCGAVERN D B.Inflammatory neuroprotection following traumatic brain injury[J].Science(American Association for the Advancement of Science),2016,353(6301):783-785.
[49] LI Y,RITZEL R M,KHAN N,et al.Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice[J].Theranostics,2020,10(25):11376-11403.
[50] REYNOLDS J L,MAHAJAN S D.Transmigration of tetraspanin 2(Tspan2)siRNA via microglia derived exosomes across the blood brain barrier modifies the production of immune mediators by microglia cells[J].J Neuroimmune Pharmacol,2020,15(3):554-563.
[51] ZHAO L,GU C,GAN Y,et al.Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis[J].J Control Release,2020,318:1-15.
[52] ESTEBANEZ B,JIMENEZ-PAVON D,HUANG C J,et al.Effects of exercise on exosome release and cargo in in vivo and ex vivo models:a systematic review[J].J Cell Physiol,2021,236(5):3336-3353.
[53] ALLEN N J,LYONS D A.Glia as architects of central nervous system formation and function[J].Science(American Association for the Advancement of Science),2018,362(6411):181-185.
[54] SOHN E J,PARK H T,SHIN Y K.Exosomes derived from differentiated schwann cells inhibit Schwann cell migration via microRNAs[J].Neuroreport,2020,31(7):515-522.
[55] MEN Y,YELICK J,JIN S,et al.Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS[J].Nature Communications,2019,10(1):4118-4136.
[56] EDBAUER D,NEILSON J R,FOSTER K A,et al.Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132[J].Neuron,2010,65(3):373-384.
[57] TRAN K A,PARTYKA P P,JIN Y,et al.Vascularization of self-assembled peptide scaffolds for spinal cord injury repair[J].Acta Biomaterialia,2020,104:76-84.
[58] HUANG X,HUSSAIN B,CHANG J.Peripheral inflammation and blood-brain barrier disruption:effects and mechanisms[J].CNS Neurosci Ther,2021,27(1):36-47.
[59] LU Y,ZHOU Y,ZHANG R,et al.Bone mesenchymal stem cell-derived extracellular vesicles promote recovery following spinal cord injury via improvement of the integrity of the blood-spinal cord barrier[J].Front Neurosci,2019,13:209-237.
[60] YUAN X,WU Q,WANG P,et al.Exosomes derived from pericytes improve microcirculation and protect blood-spinal cord barrier after spinal cord injury in mice[J].Frontiers in Neuroscience,2019,13:319-322.