[1]姜苗苗,谭勇海,严伟,等.自体生长因子联合骨髓浓缩物治疗中青年股骨颈骨折延迟愈合44例[J].中国中医骨伤科杂志,2022,30(01):57-60+64.
　JIANG Miaomiao,TAN Yonghai,YAN Wei,et al.Autologous Growth Factor combined with Bone Marrow Concentrated Ingredients in Treating the Delayed Union of Femoral Neck Fractures in Young and Middle-Aged Patients[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2022,30(01):57-60+64.
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自体生长因子联合骨髓浓缩物治疗中青年股骨颈骨折延迟愈合44例()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第30卷
期数:
2022年01期
页码:
57-60+64
栏目:
临床报道
出版日期:
2022-01-15

文章信息/Info

Title:
Autologous Growth Factor combined with Bone Marrow Concentrated Ingredients in Treating the Delayed Union of Femoral Neck Fractures in Young and Middle-Aged Patients
文章编号:
1005-0205(2022)01-0057-04
作者:
姜苗苗1; 谭勇海1; 严伟1; 孙文学1; 姜红江1△
1山东省文登整骨医院(山东 威海,264400)
Author(s):
JIANG Miaomiao1; TAN Yonghai1; YAN Wei1; SUN Wenxue1; JIANG Hongjiang1△
1Wendeng Osteopath & Rehabilitation Hospital of Shandong Province,Weihai 264400,Shandong China.
关键词:
生长因子;  骨髓;  股骨颈骨折;  延迟愈合
Keywords:
growth factor;  bone marrow;  femoral neck fracture;  delayed union
分类号:
R683.42
文献标志码:
B
摘要:
目的:探讨自体生长因子联合骨髓浓缩物治疗中青年股骨颈骨折延迟愈合的临床疗效。方法:选取本院自2018年5月至2020年5月收治的共44例股骨颈骨折延迟愈合患者。44例患者均从肘静脉处抽取100 mL的静脉血用于制备自体生长因子。自体骨髓浓缩物注射前3 d先注射自体生长因子约4 mL。麻醉成功后,从患者的髂后上脊处用肝素化的无菌针管抽取约30 mL的自体骨髓,对自体骨髓采用密度梯度离心后获得骨髓浓缩物约3 mL,送至手术室注射自体骨髓浓缩物。注射后第3天再进行1次自体生长因子的注射。分别于自体生长因子联合骨髓浓缩物治疗后的第3个月、第6个月、第9个月、第12个月随访时行X线检查,观察股骨颈骨折愈合情况、是否发生股骨头坏死、根据Nagi股骨颈骨折疗效评价标准对自体生长因子联合骨髓浓缩物治疗中青年股骨颈骨折延迟愈合的疗效进行评价。结果:44例患者均有完整的随访资料,随访时间均为12个月。其中有41例患者达到临床骨折愈合的标准,3例患者骨折未愈合且发生股骨头坏死,后期进行了股骨头置换。41例患者骨折延迟愈合的时间为3～5个月,平均3.6个月。术后功能按Nagi股骨颈骨折疗效评价标准:优38例,良3例,差3例,优良率93.2%。结论:自体生长因子联合骨髓浓缩物治疗中青年股骨颈骨折延迟愈合具有良好的临床疗效,值得临床推广应用。
Abstract:
Objective:To investigate the clinical efficacy of autologous growth factor combined with bone marrow concentrated ingredients in treating of delayed union of femoral neck fractures in young and middle-aged patients.Methods:From May 2018 to May 2020,44 cases of Delayed Union of femoral neck fracture were treated.In all 44 patients,100 mL of venous blood was drawn from the elbow vein to prepare the autologous growth factor.4 mL of autologous growth factor was injected three days before the injection of autologous bone marrow concentrated ingredients.After successful anesthesia,about 30 mL of autologous bone marrow was extracted from the patient's posterior superior ILIAC crest with a heparinized sterile needle,and 3 mL of marrow concentrated ingredients were obtained by density gradient centrifugation into the O.R.for autologous bone marrow concentrated ingredients.Another injection of autologous growth factor was given 3 d after injection.X-ray examination was performed at 3,6,9 and 12 months after the treatment of autologous growth factor combined with bone marrow concentrated ingredients to observe the healing of femoral neck fracture,femoral head necrotic condition and to evaluate the curative effect according to Nagi criteria.Results:All 44 patients had completed follow-up with 12 months.Among them,41 patients met the clinical criteria of fracture healing,3 patients had unhealed fracture and necrosis of femoral head,and had femoral head replacement at late stage.The delayed union time of 41 patients was 3～5 months(mean 3.6 months).Postoperative function according to Nagi Femoral Neck Fracture Curative Effect Evaluation Standard showed excellent with 38 cases,good with 3 cases,bad with 3 cases.The excellent good rate was 93.2%.Conclusion:The treatment of delayed union of femoral neck fracture in young and middle-aged patients with autologous growth factor and bone marrow concentrated ingredients has good clinical effect and is worthy of clinical application.

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备注/Memo

备注/Memo:
基金项目:国家中医药管理局2018年孙文学全国名老中医药专家传承工作室建设项目
△通信作者 E-mail:boneman@163.com
更新日期/Last Update: 2022-01-18