参考文献/References:
[1] LONG M J,PAPI E,DUFFEU L.Predicting knee osteoarthritis risk in injured populations[J].Clinical Biomechanics,2017,47:87-95.
[2] HART H F,CROSSLEY K M,HUNT M A.Do gait patterns differ based on radiographic patellofemoral osteoarthritis disease severity in individuals with mild tibiofemoral osteoarthritis?[J].Osteoarthritis and Cartilage,2017,25(1):S349.
[3] MARTA I,TARGINO R A,HSING W T,et al.Concentration of cytokines in patients with osteoarthritis of the knee and fibromyalgia[J].Clinical Interventions in Aging,2014,9:939-944.
[4] ZHANG H,SONG B,PAN Z X.Downregulation of microRNA-9 increases matrix metalloproteinase-13 expression levels and facilitates osteoarthritis onset[J].Mol Med Rep,2018,17(3):3708-3714.
[5] OZLER K,AKTAS E,ACAY C,et al.Serum and knee synovial fluid matrix metalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late-stage osteoarthritis[J].Acta Orthopaedica et Traumatologica Turcica,2016,50(3):356-361.
[6] 单鹏程.温阳益髓中药干预兔膝骨关节炎软骨基质金属蛋白酶的表达[J].中国组织工程研究,2014,18(7):997-1002.
[7] LU W,HE Z Y,SHI J,et al.AMD3100 attenuates post-traumatic osteoarthritis by maintaining transforming growth factor-β1-induced expression of tissue inhibitor of metalloproteinase-3 via the phosphatidylinositol 3-kinase/Akt pathway[J].Front Pharmacol,2020,10(10):1554.
[8] 孙志涛.单味药鹿茸调节骨关节炎模型兔软骨细胞外基质主要成分ADAMTS-4/TIMP-3基因的表达[J].中国组织工程研究,2018,22(32):5133-5138.
[9] FU D,SHANG X,NI Z,et al.Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis[J].Exp Ther Med,2016,12(4):2735-2740.
[10] YASSIN A M,ABUBAKR,H,ABDELGALIL A I,et al.COL2A1 and Caspase-3 as promising biomarkers for osteoarthritis prognosis in an equus asinus model[J].Biomolecules,2020,10(3):354.
[11] 金连峰.单味中药骨碎补对兔膝骨关节炎软骨细胞凋亡作用的实验研究[J].中华中医药学刊,2013,31(7):1699-1703.
[12] WANG Z,FNAG J,XIAO J.Correlation of the expression of inflammatory factors with expressionof apoptosis-related genes Bax and Bcl-2,in burned rats[J].Experimental and Therapeutic Medicine,2019,17(3):1790-1796.
[13] 柯俊泉.加味补阳还五汤对兔膝骨关节炎的治疗作用及机制[J].山东医药,2020,60(28):45-49.
[14] MUSUMECI G.Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis[J].IJMS,2015,16(9):20560-20575.
[15] 洪振强.马钱子总碱对兔膝骨关节炎模型软骨损伤修复作用及机制[J].中国中西医结合杂志,2018,38(8):991-996.
[16] 罗利飞.续断对兔膝骨关节炎模型滑膜细胞凋亡蛋白Bcl-2和Fas-L表达影响的实验研究[J].中国卫生检验杂志,2020,30(11):1322-1324.
[17] ZHU Z,OTAHA P,WANG B,et al.Longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis[J].Osteoarthritis and Cartilage,2017,25(4):499-505.
[18] MALEMUD C J.Biologic basis of osteoarthritis:state of the evidence[J].Curr Opin Rheumatol,2015,27(3):289-294.
[19] 李广广.通络治痹汤对兔膝骨关节炎软骨形态改变和炎症因子IL-1β、TNF-α水平的影响[J].中国中医基础医学杂志,2018,24(4):467-470.
[20] 杜旭召.白芍总苷对骨关节炎软骨细胞增殖及分泌表达的影响[J].中国骨质疏松杂志,2016,22(11):1375-1379.
[21] 李明,李君,付昆.骨碎补总黄酮对膝骨关节炎模型兔HIF-1α和VEGF表达的影响[J].中国药房,2018,29(18):2484-2488.
[22] SMIT Y,MARAIS H J,THOMPSON P N,et al.Clinical findings,synovial fluid cytology and growth factor concentrations after intra-articular use of a platelet-rich product in horses with osteoarthritis[J].Journal of the South African Veterinary Association,2019,90:1-9.
[23] 王功国.舒筋接骨汤治疗膝骨关节炎的临床研究[J].中国骨质疏松杂志,2016,22(10):1329-1332.
[24] LI Y,WANG Y,CHUBINSKAYA S,et al.Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage:relevance to post-traumatic osteoarthritis[J].Osteoarthritis and Cartilage,2015,23(2):266-274.
[25] 白斌.丹参对兔骨性关节炎关节软骨白介素-1β、白介素-6和胰岛素样生长因子-Ⅰ表达的影响[J].中国康复医学杂志,2015,30(10):990-994.
[26] EL-SEAUDI A,KADER T A E,NISHIDA T,et al.Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis[J].Journal of Cell Communication and Signaling,2017,11(3):255-263.
[27] 赵鹏飞.加味四妙散对兔膝骨关节炎IL-6和bFGF的影响[J].中医学报,2015,30(8):1166-1169.
[28] LU J,JI M L,ZHANG X,et al.Epigenetic silencing of MIR-375 promotes catilage degradation by targeting JAK2/STAT3 signaling pathway in knee osteoarthritis[J].Osteoarthritis and Cartilage,2017.DOI:10.1016/j.joca.2017.02.491.
[29] 严可.加味独活寄生汤对兔膝骨关节炎软骨细胞凋亡的影响[J].中国中医骨伤科杂志,2019,27(4):1-6.
[30] ZHANG Y, XU S,HUANG E, et al. MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritisthrough PTEN/PI3K/Akt signaling pathway[J]. International Journal of Molecular Medicine, 2018,41(6):30-32.
[31] 杨安群, 谢获. 当归-牛膝对兔骨关节炎PI3K/AKT通路的影响[J]. 放射免疫学杂志, 2012,25(05):526-529.
[32] JO S,WANG S E,LEE Y L, et al. IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis[J]. BioMed Central, 2018,20(1):115.
[33] 李虎业, 窦增花, 孔德元, 等. 山茱萸新苷Ⅰ干预膝骨关节炎模型大鼠抑制白细胞介素6介导的炎性反应[J]. 中国组织工程研究, 2021,25(02):211-215.
[34] WEI L,DING Z F,LIU F,et al.Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-κB and JAK2/STAT3 signaling pathways[J].Biomedecine & Pharmacotherapie,2019,119:109419.
[35] 陈伟达.川续断总皂苷调节miR-19a对大鼠骨关节炎软骨细胞SOX9/NF-κB信号通路的影响[J].中国药师,2020,23(5):824-829.
[36] PENG H Z,YUN Z,WANG W,et al.Dual specificity phosphatase 1 has a protective role in osteoarthritisfibroblast-like synoviocytes via inhibition of the MAPK signaling pathway[J].Molecular Medicine Reports,2017,16(6):8441-8447.
[37] 林嘉辉.龟甲胶和鹿角胶含药血清对豚鼠骨关节炎软骨细胞JNK及p38 MAPK基因表达的影响[J].中国中医骨伤科杂志,2016,24(10):1-4.
[38] PENG W X,XIE W P,BI F,et al.Quercetin suppresses apoptosis of chondrocytes induced by IL-1β via inactivation of p38 MAPK signaling pathway[J].Experimental and Therapeutic Medicine,2021,21(5):468.
[39] 姚弘毅.羟基红花黄色素A对骨性关节炎模型大鼠炎症因子水平及Notch信号通路的影响[J].中国医药,2020,15(6):927-931.