[1]张虎林 喻琳△ 王亮 汪小敏 谢泽慧.膝骨性关节炎关键信号通路的研究进展[J].中国中医骨伤科杂志,2021,29(10):84-88.
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膝骨性关节炎关键信号通路的研究进展()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第29卷
期数:
2021年10期
页码:
84-88
栏目:
文献综述
出版日期:
2021-10-15

文章信息/Info

文章编号:
1005-0205(2021)10-0084-05
作者:
张虎林1 喻琳1△ 王亮2 汪小敏1 谢泽慧3
1甘肃中医药大学附属医院(兰州,730020)2甘肃中医药大学3兰州大学
关键词:
膝骨性关节炎 信号通路 综述
分类号:
R684.3
文献标志码:
A

参考文献/References:

[1] 中华医学会骨科学分会关节外科学组.骨关节炎诊疗指南(2018年版)[J].中华骨科杂志,2018,38(12):705-715.
[2] ZHOU Y,WANG T,HAMILTON J L,et al.Wnt/β-catenin signaling in osteoarthritis and in other forms of arthritis[J].Curr Rheumatol Rep,2017,19(9):53.
[3] NUSSE R, VARMUS H E.Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome[J].Cell,1982,31(1):99-109.
[4] DE SANTIS M, DI MATTEO B, CHISARI E,et al.The role of wnt pathway in the pathogenesis of OA and its potential therapeutic implications in the field of regenerative medicine[J].Biomed Research International,2018:7402947.
[5] JAVIER F T, YESSICA Z C, ALBERTO L R,et al.Gene-gene interactions of the Wnt/β-catenin signaling pathway in knee osteoarthritis[J].Molecular Biology Reports,2018,45(5):1089-1098.
[6] WANG Y,FAN X,XING L,et al.Wnt signaling:a promising target for osteoarthritis therapy[J].Cell Communication and Signaling,2019,17(1):97.
[7] GAO S G,ZENG C,LIU J J,T et al.Association between Wnt inhibitory factor-1 expression levels in articular cartilage and the disease severity of patients with osteoarthritis of the knee[J].Exp Ther Med,2016,11(4):1405-1409.
[8] D’SOUZA B, MELOTY-KAPELLA L, WEINMASTER G.Canonical and non-canonical notch ligands[J].Current Topics in Developmental Biology,2010,92(10):73-129.
[9] DONG Y, JESSE A M, KOHN A,et al.RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development[J].Development,2010,137(9):1461-1471.
[10] SEKINE C, KOYANAGI A, KOYAMA N.Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes[J].Arthritis Research & Therapy,2012,14(2):R45.
[11] LIU Z, REN Y, MIRANDO A J,et al.Notch signaling in postnatal joint chondrocytes,but not subchondral osteoblasts,is required for articular cartilage and joint maintenance[J].Osteoarthritis Cartilage,2016,24(4):740-751.
[12] CALICETI C, NIGRO P, RIZZO P,et al.ROS,notch,and Wnt signaling pathways:crosstalk between three major regulators of cardiovascular biology[J].BioMed Research International,2014,2014(6):318714.
[13] ZHENG Y X,LIU C C,NI L,et al.Cell type-specific effects of Notch signaling activation on intervertebral discs:Implications for intervertebral disc degeneration[J].J Cellular Physiology,2018,233(7):5431-5440.
[14] LIU Z,CHEN J,MIRANDO A J,et al.A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis[J].Sci Signal,2015,8(386):ra71.
[15] YU H T,GU C Z,CHEN J Q.MiR-9 facilitates cartilage regeneration of osteoarthritis in rabbits through regulating Notch signaling pathway[J].European Review for Medical and Pharmacological Sciences,2019,23(12):5051-5058.
[16] SEN R.Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism.[J].Cell,1986,47(6):921-928.
[17] 谈冰,刘健,章平衡.基于NF-κB及细胞因子的变化探讨骨关节炎患者高凝状态的机制[J].免疫学杂志,2015(10):882-887.
[18] SIMMONDS R E, FOXWELL B M.Signalling,inflammation and arthritis:NF-κB and its relevance to arthritis and inflammation[J].Rheumatology(Oxford),2008,47(5):584-590.
[19] CHOI M C, JO J, PARK J,et al.NF-κB signaling pathways in osteoarthritic cartilage destruction[J].Cells,2019,8(7):734.
[20] ERIKA T, STEFANIA M, PAOLA C,et al.Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-κB pathway activation[J].PLoS ONE,2014,9(1):e84358.
[21] ZHANG L B,MAN Z T,LI W,et al.Calcitonin protects chondrocytes from lipopolysaccharide-induced apoptosis and inflammatory response through MAPK/Wnt/NF-κB pathways[J].Molecular Immunology,2017,87:249-257.
[22] WANG W,LI J,LI F,et al.Scutellarin suppresses cartilage destruction in osteoarthritis mouse model by inhibiting the NF-κB and PI3K/AKT signaling pathways[J].Int Immunopharmacol,2019,77:105928.
[23] HARIKRISHNAN H, JANTAN I, HAQUE M AA,et al.Anti-inflammatory effects of hypophyllanthin and niranthin through downregulation of NF-κB/MAPKs/PI3K-Akt signaling pathways[J].Inflammation,2018,41(3):1-12.
[24] XU J,YI Y,LI L,et al.Osteopontin induces vascular endothelial growth factor expression in articular cartilage through PI3K/AKT and ERK1/2 signaling[J].Mol Med Rep,2015,12(3):4708-4712.
[25] MUSUMECI G, CASTROGIOVANNI P, TROVATO F M,et al.Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis[J].Int J Mol Sci,2015,16(9):20560-20575.
[26] XUE J,SHI Z,ZOU J,et al.Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis[J].Biomedicine & Pharmacotherapy,2017,89:1252-1261.
[27] 颜春鲁,牛彦强,李盛华,等.右归丸通过PI3K/Akt/mTOR信号通路对膝骨关节炎模型鼠软骨组织保护作用的研究[J].中国骨质疏松杂志,2020,26(3):318-322.
[28] PAL B, ENDISHA H, ZHANG Y,et al.mTOR:a potential therapeutic target in osteoarthritis?[J].Drugs in R & D,2015,15(1):27-36.
[29] WALSH M C, CHOI Y.Biology of the RANKL-RANK-OPG system in immunity,bone,and beyond[J].Frontiers in Immunology,2014,5:511.
[30] NELSON C A, WARREN J T, WANG M W H,et al.RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor[J].Structure,2012,20(11):1971-1982.
[31] WANG X F,ZHANG Y K,YU Z S,et al.The role of the serum RANKL/OPG ratio in the healing of intertrochanteric fractures in elderly patients[J].Molecular Medicine Reports,2013,7(4):1169-1172.
[32] TSUSHIMA H, OKAZAKI K, ISHIHARA K,et al.CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-κB ligand(RANKL)expression and osteoclast formation in the synovium in rheumatoid arthritis[J].Arthritis Research & Therapy,2015,17(1):1-11.
[33] KOVCS B, VAJDA E, NAGY E E.Regulatory effects and interactions of the Wnt and OPG-RANKL-RANK signaling at the bone-cartilage interface in osteoarthritis[J].International Journal of Molecularences,2019,20(18):4653.
[34] KOURA H M, ZAKI S M, ISMAIL N A,et al.Relationship between biochemical bone markers and bone mineral density in patients with phenylketonuria under restricted diet[J].Iran J Pediatr,2014,24(1):23-28.
[35] LIU Y,GE J,CHEN D,et al.Osteoprotegerin deficiency leads to deformation of the articular cartilage in femoral head [J].Journal of Molecular Histology,2016,47(5):1-9.

备注/Memo

备注/Memo:
基金项目:甘肃省自然科学基金资助项目(18JR3RA077)
兰州市卫生健康科技发展项目(2019-050)
甘肃中医药大学附属医院一般项目(gzfy-2018-04)
甘肃中医药大学附属医院一般项目(gzfy-2019-24)
通信作者 E-mail:1482509544@qq.com
更新日期/Last Update: 1900-01-01