[1]应璞 戴小宇△ 许岳 蒋晓伟 周烨 路通 薛燚 王强.血脂与非创伤性股骨头坏死行全髋关节置换术后下肢深静脉血栓的相关性分析[J].中国中医骨伤科杂志,2021,29(10):28-31.
 YING Pu DAI Xiaoyu XU Yue JIANG XiaoweiZHOU Ye LU Tong XUE Yi WANG Qiang.Correlation Analysis between Blood Lipids and Deep VenousThrombosis of Low Limb in Patients with Non-Traumatic Osteonecrosisof the Femoral Head after Total Hip Arthroplasty[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2021,29(10):28-31.
点击复制

血脂与非创伤性股骨头坏死行全髋关节置换术后下肢深静脉血栓的相关性分析()
分享到:

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第29卷
期数:
2021年10期
页码:
28-31
栏目:
临床研究
出版日期:
2021-10-15

文章信息/Info

Title:
Correlation Analysis between Blood Lipids and Deep VenousThrombosis of Low Limb in Patients with Non-Traumatic Osteonecrosisof the Femoral Head after Total Hip Arthroplasty
文章编号:
1005-0205(2021)10-0028-04
作者:
应璞1 戴小宇2△ 许岳1 蒋晓伟1 周烨1 路通1 薛燚1 王强1
1南京中医药大学常熟附属医院(江苏 常熟,215500)2苏州大学附属第三医院/常州市第一人民医院骨科
Author(s):
YING Pu1 DAI Xiaoyu2△ XU Yue1 JIANG Xiaowei1ZHOU Ye1 LU Tong1 XUE Yi1 WANG Qiang1
1Changshu Hospital Affiliated to Nanjing University of Chinese Medicine,Changshu 215500,Jiangsu China; 2The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou),Changzhou 213000,Jiangsu China.
关键词:
血脂 股骨头坏死 全髋关节置换术 深静脉血栓
Keywords:
lipids non-traumatic osteonecrosis of the femoral head total hip arthroplasty deep vein thrombosis
分类号:
R681.8
文献标志码:
A
摘要:
目的:评估非创伤性股骨头坏死(Osteonecrosis of the Femoral Head,ONFH)患者术前血脂水平与行全髋关节置换术(Total Hip Arthroplasty,THA)后下肢深静脉血栓(Deep Venous Thrombosis,DVT)发生的相关性。方法:2014年8月至2020年1月行THA术的ONFH患者共224例,所有患者均在术后第3天行双下肢静脉B超。根据检查结果分为DVT组(男12例,女18例,平均年龄60.63岁)和非DVT组(男84例,女110例,平均年龄57.97岁),通过多变量Logistic回归分析两组患者术前血清甘油三酯(Triglycerides,TG),总胆固醇(Total Cholesterol,TC),高密度脂蛋白胆固醇(High-density Lipoprotein Cholesterol,HDL-C)、低密度脂蛋白胆固醇(Low-density Lipoprotein Cholesterol,LDL-C)水平与术后DVT发生风险的相关性。结果:女性ONFH患者中,DVT组TG值明显高于非DVT组,差异有统计学意义(P=0.029),且高TG值与DVT的发生正相关(P=0.042)。结论:高TG水平是女性非创伤性ONFH患者行THA术后DVT发生的危险因素。
Abstract:
Objective:To evaluate the association of serum lipids and deep vein thrombosis(DVT)risk following total hip arthroplasty(THA)in patients with non-traumatic osteonecrosis of the femoral head(ONFH).Methods:A total of 224 non-traumatic ONFH patients who had undergone total hip arthroplasty(THA)underwent the color Doppler ultrasound of bilateral lower-extremities deep veins on 3 d postoperatively from August 2014 to January 2020.Based on the inspection results,patients were divided into DVT group(12 males and 18 females,mean age was 60.63 years old)and non-DVT group(84 males and 110 females,mean age was 57.97 years old).The association of serum triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)levels and postoperative DVT risk were analyzed by the multivariate Logistic analysis.Results:In females,DVT patients had a higher serum TG level than that in non-DVT patients(P=0.029)and a higher TG level was significantly associated with DVT(P=0.042).Conclusion:An increased TG level is a risk factor of DVT after THA in female non-traumatic ONFH patients.

参考文献/References:

[1] 潘鑫戊,谢兴文,黄晋,等.股骨头坏死保髋治疗的研究进展[J].中国中医骨伤科杂志,2016,24(12):74-78.
[2] SODHI N,ACUNA A,ETCHESON J,et al.Management of osteonecrosis of the femoral head[J].Bone Joint J,2020,102-B(7B):122-128.
[3] GEERTS W H,BERGQVIST D,PINEO G F,et al.Prevention of venous thromboembolism:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines(8th Edition)[J].Chest,2008,133(6):S381-S453.
[4] ZHAO D,ZHANG F,WANG B,et al.Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults(2019 version)[J].J Orthop Translat,2020,21:100-110.
[5] CHANG C,GREENSPAN A,GERSHWIN M E.The pathogenesis,diagnosis and clinical manifestations of steroid-induced osteonecrosis[J].J Autoimmun,2020,110:102460.
[6] SONG Y,DU Z,CHEN B,et al.Association of SREBP2 gene polymorphisms with the risk of osteonecrosis of the femoral head relates to gene expression and lipid metabolism disorders[J].Mol Med Rep,2017,16(5):7145-7153.
[7] LIU X,LI Q,SHENG J,et al.Unique plasma metabolomic signature of osteonecrosis of the femoral head[J].J Orthop Res,2016,34(7):1158-1167.
[8] MARSTON N A,GURMU Y,MELLONI G E M,et al.The effect of PCSK9(proprotein convertase subtilisin/kexin type 9)inhibition on the risk of venous thromboembolism[J].Circulation,2020,141(20):1600-1607.
[9] TRIANTAPHYLLIDOU I E,KALYVIOTI E,KARAVIA E,et al.Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet[J].Osteoarthritis Cartilage,2013,21(2):322-330.
[10] 中国医师协会骨科医师分会骨循环与骨坏死专业委员会,中华医学会骨科分会骨显微修复学组,国际骨循环学会中国区.中国成人股骨头坏死临床诊疗指南(2020)[J].中华骨科杂志,2020,40(20):1365-1376.
[11] ZHANG S,CHU W,WANG H,et al.Evaluation of stability of deep venous thrombosis of the lower extremities using Doppler ultrasound[J].J Int Med Res,2020,48(8):300060520942098.
[12] 中华医学会.深静脉血栓形成的诊断和治疗指南(第三版)[J].中华血管外科杂志,2017(4):201-208.
[13] 王奕凯,李璐,于炜婷,等.非创伤性股骨头坏死中纤溶酶原激活物抑制剂-1作用机制的研究进展[J].中华骨与关节外科杂志,2020,13(10):874-880.
[14] HOLST A G,JENSEN G,PRESCOTT E.Risk factors for venous thromboembolism:results from the Copenhagen City Heart Study[J].Circulation,2010,121(17):1896-1903.
[15] STEFFEN L M,CUSHMAN M,PEACOCK J M,et al.Metabolic syndrome and risk of venous thromboembolism:longitudinal investigation of thromboembolism etiology[J].J Thromb Haemost,2009,7(5):746-751.
[16] LIMA J J,MAURAS N,KISSOON N,et al.Influence of sex and beta2 adrenergic receptor haplotype on resting and terbutaline-stimulated whole body lipolysis[J].Metabolism,2005,54(4):492-499.
[17] MITTENDORFER B.Sexual dimorphism in human lipid metabolism[J].J Nutr,2005,135(4):681-686.
[18] GLUECK C J,FREIBERG R A,WANG P.Role of thrombosis in osteonecrosis[J].Curr Hematol Rep,2003,2(5):417-422.

备注/Memo

备注/Memo:
基金项目:苏州市“科教兴卫”青年科技项目(KJXW2020068)
南京中医药大学常熟附属医院课题(cszyy201910)
通信作者 E-mail:dxyiverson3@163.com
更新日期/Last Update: 1900-01-01