参考文献/References:
[1] DESMOULIN G T,PRADHAN V,MILNER T E.Mechanical aspects of intervertebral disc injury and implications on biomechanics[J].Spine(Phila Pa 1976),2020,45(8):457-464.
[2] DOWDELL J,ERWIN M,CHOMA T,et al.Intervertebral disk degeneration and repair[J].Neurosurgery,2017,80(3S):46-54.
[3] ALVAREZ-GARCIA O,MATSUZAKI T,OLMER M,et al.FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration[J].Aging Cell,2018,17(5):e12800.
[4] WANG S Z,RUI Y F,TAN Q,et al.Enhancing intervertebral disc repair and regeneration through biology:platelet-rich plasma as an alternative strategy[J].Arthritis Research & Therapy,2013,15(5):220.
[5] HE R,CUI M,LIN H,et al.Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells[J].Life Sciences,2018,199:122-130.
[6] JIANG W,ZHANG X M,HAO J,et al.SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells[J].Scientific Reports,2014,4:7456.
[7] DING F,SHAO Z W,XIONG L M.Cell death in intervertebral discdegeneration[J].Apoptosis,2013,18(7):777-785.
[8] HONG J,LI S,MARKOVA D Z,Liang A,et al.Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells[J].Cell Physiol,2020,235(7/8):5736-5749.
[9] LIN J,ZHUGE J,ZHENG X,et al.Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway[J].Free Radic Biol Med,2020,150:109-119.
[10] HONG J,YAN J,CHEN J,et al.Identification of key potential targets for TNF-α/TNFR1-related intervertebral disc degeneration by bioinformatics analysis[J].Connect Tissue Res,2020,26:1-11.
[11] LI Z,ZHANG K,LI X,et al.Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-α/NF-κB-Wnt5a negative-feedback loop[J].Osteoarthritis Cartilage,2018,26(7):966-977.
[12] KANG L,LIU S,LI J,et al.The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance[J].Cell Prolif,2020,53(3):e12779.
[13] CUI L,WEI H,LI Z M,et al.TGF-β1 aggravates degenerative nucleus pulposus cells inflammation and fibrosis through the upregulation of angiopoietin-like protein 2 expression[J].Eur Rev Med Pharmacol Sci,2020,24(23):12025-12033.
[14] LI H,LI W,LIANG B,et al.Role of AP-2α/TGF-β1/Smad3 axis in rats with intervertebral disc degeneration[J].Life Sci,2020,263:118567.
[15] FUBIAO Y E,WANG H,ZHENG Z M,et al.Role of SHOX2 in the development of intervertebral disc degeneration[J].Journal of Orthopaedic Research,2017,35(5):1047-1057.
[16] SUDO H,MINAMI A.Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression[J].J Orthop Res,2010,28:1608-1613.
[17] VAN DEURSEN J M.The role of senescent cells in ageing[J].Nature,2014,509(7501):439-446.
[18] MIYAZAKI S.Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells[J].Arthritis Res Ther,2015,17(1):253.
[19] YANG L,RONG Z,ZENG M,et al.Pyrroloquinoline quinone protects nucleus pulposus cells from hydrogen peroxide-induced apoptosis by inhibiting the mitochondria-mediated pathway[J].Eur Spine J,2015,24(8):1702-1710.
[20] JIANG X,XIE L,HUANG C,et al.Oral oxymatrine for hepatitis B cirrhosis:a systematic review protocol[J].Medicine(Baltimore),2018,97(49):e13482.
[21] WANG Y,CHE M,XIN J,et al.The role of IL-1β and TNF-α in intervertebral disc degeneration[J].Biomed Pharmacother,2020,131:110660.
[22] QIU X,ZHUANG M,LU Z,et al.RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs[J].Transl Med,2019,17(1):135.
[23] TEKIRDAG K A,KORKMAZ G,OZTURK D G,et al.MIR181A regulates starvation-and rapamycin-induced autophagy through targeting of ATG5[J].Autophagy,2013,9(3):374-385.
[24] NAKATOGAWA H.Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy[J].Essays Biochem,2013,55:39-50.
[25] ZONCU R,EFEKAN A,SABATINI D M.mTOR:from growth signal integration to cancer,diabetes and ageing[J].Nat Rev Mol Cell Biol,2011,12(1):21-35.
[26] LAPLANTE M,SABATINI D M.mTOR signaling in growth control and disease[J].Cell,2012,149(2):274-293.
[27] LIU P,GAN W,CHIN Y R,et al.PtdIns(3,4,5)P3-dependent activation of the mTOR C2 kinase complex[J].Cancer Discov,2015,5(11):1194-1209.
[28] DIBBLE C C,ELIS W,MENON S,et al.TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1[J].Mol Cell,2012,47(4):535-546.
[29] CARROLL B,DUNLOP E A.The lysosome:A crucial hub for AMPK and mTOR C1 signalling[J].Biochem,2017,474(9):1453-1466.
[30] ANTONIOLI M,DI RIENZO M,PIACENTINI M.Emerging mechanisms in initiating and terminating autophagy[J].Trends Biochem Sci,2017,42(1):28-41.
[31] RABANAL-RUIZ Y,OTTEN E G,KOROLCHUK V I.mTOR C1 as the main gateway to autophagy[J].Essays Biochem,2017,61(6):565-584.
[32] RYTER S W,MIZUMURA K,CHOI A M.The impact of autophagy on cell death modalities[J].Int J Cell Biol,2014:502676.
[33] HE C,ZHU H,LI H,et al.Dissociation of Bcl-2-Beclin 1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes[J].Diabetes,2013,62(4):1270-1281.
[34] KONG C G,PARK J B,MAN S K,et al.High Glucose accelerates autophagy in adult rat intervertebral disc cells[J].Asian Spine J,2014,8(5):543-548.
[35] ZHANG Q C,HU S Q,HU A N,et al.Autophagy-activated nucleus pulposus cells deliver exosomal miR-27a to prevent extracellular matrix degradation by targeting MMP-13[J].Orthop Res,2020.DOI:10.1002/jor.24880.
[36] ZHAO K,ZHANG Y,KANG L,et al.Methylation of microRNA-129-5P modulates nucleus pulposus cell autophagy by targeting Beclin-1 in intervertebral disc degeneration[J].Oncotarget,2017,8(49):86264-86276.
[37] SHEN C,YAN J,JIANG L S,et al.Autophagy in rat annulus fibrosus cells:evidence and possible implications[J].Arthritis Res Ther,2011,13(4):R132.
[38] ZHENG Z,WANG Z G,CHEN Y,et al.Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration[J].J Cell Mol Med,2018,22(6):3086-3096.
[39] QUAN M,HONG M W,KO M S,et al.Relationships between disc degeneration and autophagy expression in human nucleus pulposus[J].Orthop Surg,2020,12(1):312-320.
[40] MIYAZAKI S,KAKUTANI K,YURUBE T,et al.Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells[J].Arthritis Res Ther,2015,17(1):253.
[41] KONG C G,PARK J B,KIM M Set al.High glucose accelerates autophagy in adult rat intervertebral disc cells[J].Asian Spine,2014,8(5):543-548.
[42] ZOU L,LEI H,SHEN J,et al.HO-1 induced autophagy protects against IL-1 β-mediated apoptosis in human nucleus pulposus cells by inhibiting NF-κB[J].Aging(Albany N Y),2020,12(3):2440-2452.
[43] SASAKI H,TAKAYAMA K,MATSUSHITA T,et al.Autophagy modulates osteoarthritis-related gene expression in human chondrocytes[J].Arthritis Rheum,2012; 64(6):1920-1928.
[44] HE J,ZHANG G,PANG Q,et al.SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition[J].FEBS,2017,284(9):1324-1337.
[45] TAKASAKA N,ARAYA J,HARA H,et al.Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence[J].Immunol,2014,192(3):958-968.
[46] VAN DEURSEN J M.The role of senescent cells in ageing[J].Nature,2014,509(7501):439-446.
[47] NORMAN J M,COHEN G M,BAMPTON E T W.The in vitro cleavage of the hAtg proteins by cell death proteases[J].Autophagy,2010,6(8):1042-1056.
[48] DJAVAHERI-MERGNY M,MAIURI M C,KROEMER G.Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1[J].Oncogene,2010,29(12):1717-1719.
[49] ORAL O,AKKOC Y,BAYRAKTAR O,et al.Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis[J].Histol Histopathol,2016,31(5):479-498.
[50] PAGLIARINI V,WIRAWAN E,ROMAGNOLI A,et al.Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response[J].Cell Death Differ,2012,19(9):1495-1504.
[51] WIRAWAN E,VANDE WALLE L,KERSSE K,et al.Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria[J].Cell Death Disease,2010,1(1):18.
[52] SUN Q,GAO W,LOUGHRAN P,et al.Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress[J].J Biol Chem,2013,288(22):15947-15958.
[53] LAUSSMANN M A,PASSANTE E,DüSSMANN H,et al.Proteasome inhibition can induce an autophagy-dependent apical activation of Caspase-8[J].Cell Death Differ,2011,18(10):1584-1597.
[54] YOU M,SAVARAJ N,KUO M T,et al.TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation[J].Mol Cell Biochem,2013,374(1/2):181-190.
[55] KANG R,ZEH H J,LOTZE M T,et al.The Beclin-1 network regulates autophagy and apoptosis[J].Cell Death Differ,2011,18(4):571-580.
[56] BOOTH L A,TAVALLAI S,HAMED H A,et al.The role of cell signalling in the crosstalk between autophagy and apoptosis[J].Cell Signal,2014,26(3):549-555.
[57] MARINO G,NISO-SANTANO M,BAEHRECKE E H,et al.Self-consumption:the interplay of autophagy and apoptosis[J].Nat Rev Mol Cell Biol,2014,15(2):81-94.
[58] BELL B D,LEVERRIER S,WEIST B M,et al.FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells[J].Proc Natl Acad Sci USA,2008,105(43):16677-16682.
[59] CHIPUK J E,MOLDOVEANU T,LLAMBI F,et al.The BCL-2 family reunion[J].Mol Cell,2010,37(3):299-310.
[60] WEI Y,PATTINGRE S,SINHA S,et al.JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy[J].Mol Cell,2008,30(6):678-688.
[61] KUMAR D,SHANKAR S,SRIVASTAVA R K.Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells:molecular mechanisms[J].Mol Cancer,2013,12(1):171.
[62] CHEN J,XIE J J,JIN M Y,et al.Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration[J].Cell Death Dis,2018,9(2):56.