[1]卢承印 王朋涛 张来福 张海龙 谢艳 王孝辉.骨髓间充质干细胞结合自体骨植骨治疗四肢骨折术后骨不连28例[J].中国中医骨伤科杂志,2021,29(09):50-54.
　LU Chengyin WANG Pengtao ZHANG LaifuZHANG Hailong XIE Yan WANG Xiaohui.28 Cases of Clinical Observation of BMSCs Combined with AutologousBone Graft in the Treatment of Nonunion after Limb Fracture Surgery[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2021,29(09):50-54.
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骨髓间充质干细胞结合自体骨植骨治疗四肢骨折术后骨不连28例()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第29卷
期数:
2021年09期
页码:
50-54
栏目:
临床报道
出版日期:
2021-09-15

文章信息/Info

Title:
28 Cases of Clinical Observation of BMSCs Combined with AutologousBone Graft in the Treatment of Nonunion after Limb Fracture Surgery
文章编号:
1005-0205(2021)09-0050-05
作者:
卢承印1 王朋涛1 张来福1 张海龙2 谢艳2 王孝辉2
1河南中医药大学(郑州,450046)
2河南省洛阳正骨医院/河南省骨科医院
Author(s):
LU Chengyin1 WANG Pengtao1 ZHANG Laifu1ZHANG Hailong2 XIE Yan2 WANG Xiaohui2
1Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China; 2Henan Luoyang Orthopaedic Hospital,Luoyang 471002,Henan China.
关键词:
骨不连;  植骨;  骨髓间充质干细胞;  修复
Keywords:
nonunion;  bone graft;  bone marrow mesenchymal stem cells;  repair
分类号:
R683.4
文献标志码:
A
摘要:
目的:探讨骨髓间充质干细胞结合自体骨植骨治疗四肢骨折术后骨不连的临床疗效。方法:回顾性分析2016年1月至2019年12月采用骨髓间充质干细胞结合自体骨植骨治疗的四肢骨折术后骨不连患者28例。其中男19例,女9例; 年龄24～63岁,平均(46.31±7.47)岁。骨折部位:尺骨8例,肱骨6例,胫骨12例,股骨2例,均为单侧骨折。钢板螺钉固定15例,髓内针固定9例,外固定架固定4例。病程8～15个月,平均(8.49±1.37)个月。记录患者手术时间、术中出血量、骨折愈合时间及不良事件发生情况,末次随访时采用Johner-Wruhs评分对优良率进行评价。结果:本组患者均获得随访6～24个月,平均(13.46±3.73)个月。手术时间55～110 min,平均(84.92±16.27)min; 术中出血量60～150 mL,平均(104.98±27.45)mL。所有患者骨不连均于术后5～8个月获得影像学愈合,平均(6.31±1.13)个月。1例患者出现泌尿系感染,对症处理后治愈,其余无伤口感染,肌腱、神经、血管损伤,深静脉血栓以及钢板断裂等不良事件发生。末次随访时采用Johner-Wruhs评分标准评价优良率,结果显示:优24例,良3例,可1例,优良率为96.4%。结论:骨髓间充质干细胞结合自体骨植骨治疗四肢骨折术后骨不连疗效确切,安全性高,值得临床推广应用。
Abstract:
Objective:To investigate the clinical effect of BMSCs combined with autologous bone graft in the treatment of nonunion after limb fracture surgery.Methods:From January 2016 to December 2019,28 patients with nonunion after limb fracture surgery were treated with bone marrow mesenchymal stem cells combined with autogenous bone graft.There were 19 males and 9 females,aged from 24 to 63 years old,with an average of(46.31±7.47)years old.Fracture parts involved ulna with 8 cases,humerus with 6 cases,tibia with 12 cases,femur with 2 cases,all were unilateral fractures,15 cases were fixed with plate and screw,9 cases were fixed with intramedullary nail,4 cases were fixed with external fixation.The course of disease ranged from 8 to 15 months,with an average of(8.49±1.37)months.The operation time,intraoperative blood loss,fracture healing time and adverse events were recorded.Johner-Wruhs score was used to evaluate the excellent and good rate at the last follow-up.Results:All patients were followed up for 6 to 24 months,with an average of(13.46±3.73)months.The operative time was 55 to 110 min,with(84.92±16.27)min on average.The intraoperative blood loss was 60 to 150 mL,with(104.98 6±27.45)mL on average.All patients obtained radiographic healing at 5 to 8 months postoperatively,with(6.31±1.13)months on average.One patient developed urinary tract infection and was cured after symptomatic treatment.No other adverse events such as wound infection,tendon,nerve,vascular injury,deep vein thrombosis and plate rupture occurred.At the last follow-up,Johner-Wruhs score was used to evaluate the excellent and good rate.The results showed that 24 cases were excellent,3 cases were good,1 case was fair,and the excellent and good rate was 96.4%.Conclusion:BMSCs combined with autogenous bone graft is effective and safe in the treatment of nonunion after limb fracture surgery,which is worthy of being promotion.

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备注/Memo

备注/Memo:
基金项目:河南省中医药科学研究专项课题(2018ZY2020)河南省重点研发与推广专项(科技攻关)项目(202102310855)
更新日期/Last Update: 1900-01-01