[1]李洪涛 侯俊军 李传庆 孙晓伟△.冲击波联合骨蚀胶囊治疗早期激素性股骨头坏死69例[J].中国中医骨伤科杂志,2021,29(06):49-53.
　LI Hongtao HOU Junjun LI Chuanqing SUN Xiaowei.69 Cases Observation on the Effect of Extracorporeal Shock WaveCombined with Gushi Capsule on Steroid-Induced AvaseularNeeresis of Femoral Head in the Early Stage[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2021,29(06):49-53.
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冲击波联合骨蚀胶囊治疗早期激素性股骨头坏死69例()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第29卷
期数:
2021年06期
页码:
49-53
栏目:
临床报道
出版日期:
2021-06-15

文章信息/Info

Title:
69 Cases Observation on the Effect of Extracorporeal Shock WaveCombined with Gushi Capsule on Steroid-Induced AvaseularNeeresis of Femoral Head in the Early Stage
文章编号:
1005-0205(2021)06-0049-05
作者:
李洪涛1; 2 侯俊军1 李传庆1 孙晓伟1; 2△
1黑龙江中医药大学(哈尔滨,150040)2黑龙江中医药大学附属第一医院
Author(s):
LI Hongtao1; 2 HOU Junjun1 LI Chuanqing1 SUN Xiaowei1; 2△
1Heilongjiang University of Chinese Medicine, Harbin 150040,China; 2The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China.
关键词:
激素性股骨头坏死;  冲击波;  骨蚀胶囊;  核转录因子
Keywords:
steroid-induced avaseular neeresis of femoral head(SANFH);  extracorporeal shock wave(ESW);  Gushi capsule;  nuclear transcription factor
分类号:
R681.8
文献标志码:
B
摘要:
目的:探讨冲击波(Extracorporeal Shock Wave,ESW)联合骨蚀胶囊治疗早期激素性股骨头坏死(Steroid-Induced Avaseular Neeresis of Femoral Head,SANFH)的临床疗效,血清Toll样受体-4(Toll Like Receptor-4,TLR4)和核转录因子Kappa B(Nuclear Transcription Factor-κB,NF-κB)的表达。方法:选取2017 年 3月至 2019年 3月就诊的早期(ARCO分期Ⅰ、Ⅱ、Ⅲa期)激素性股骨头坏死患者 69 例,给予冲击波联合骨蚀胶囊治疗。比较患者治疗前后的临床疗效(包括疼痛、关节活动度、骨质改善情况等)的变化差异以及患者血清TLR4 和NF-κB含量水平的变化。结果:3组患者在接受治疗后 Harris 评分中疼痛积分、功能积分和关节活动度均明显高于治疗前(P<0.05),给予冲击波联合骨蚀胶囊治疗干预后患者血清TLR4和NF-κB明显下降,差异均有统计学意义(P<0.05)。结论:冲击波联合骨蚀胶囊对早期的SANFH患者有较好的临床效果,其治疗中发挥的作用可能与其调节TLR4和NF-κB 的表达有关。
Abstract:
To observe the clinical efficacy of extracorporeal shock wave(ESW)combined with Gushi capsule in the treatment of steroid-induced avaseular neeresis of femoral head(SANFH)in the early stage and the expression of toll like receptor-4(TLR4), nuclear transcription factor-κB(NF-κB). Methods:69 patients with SANFH(stage Ⅰ,Ⅱ and Ⅲ)were selected and treated with ESW combined with Gushi capsule from March 2017 to March 2019. The changes of clinical efficacy(including pain, joint activity, bone improvement, etc.)and the levels of TLR4 and NF-κB in serum were compared before and after treatment. Methods:The pain score, function score and joint activity score of patients in the early stage were significantly higher(P<0.05), TLR4 and NF-κB were significantly decreased(P<0.05). Conclusion:ESW combined with Gushi capsule has good clinical efficacy for the early stage of SANFH, and its role in treatment may be related to the regulation of TLR4 and NF-κB expression.

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备注/Memo

备注/Memo:
基金项目:黑龙江省博士后科研启动基金(21092200033)黑龙江省自然科学基金(H2017058)
△通信作者 E-mail:gemini19790530@163.com
更新日期/Last Update: 2021-06-15