[1]崔龙慷 刘全 李振 李学飞 沈高波 方源 吴连国.强骨饮对骨质疏松症老年女性患者血清炎症细胞因子、骨保护素、核因子κB受体活化因子配体及骨密度的影响[J].中国中医骨伤科杂志,2021,29(03):30-35.
　CUI Longkang LIU Quan LI Zhen LI Xuefei SHEN Gaobo FANG Yuan WU Lianguo.Effect of Qiangguyin on Inflammatory Cytokines and OPG and RANKL and Bone Mineral Density in Serum in Senile Female Patients with Osteoporosis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2021,29(03):30-35.
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强骨饮对骨质疏松症老年女性患者血清炎症细胞因子、骨保护素、核因子κB受体活化因子配体及骨密度的影响()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第29卷
期数:
2021年03期
页码:
30-35
栏目:
临床研究
出版日期:
2021-03-15

文章信息/Info

Title:
Effect of Qiangguyin on Inflammatory Cytokines and OPG and RANKL and Bone Mineral Density in Serum in Senile Female Patients with Osteoporosis
文章编号:
1005-0205(2021)03-0030-06
作者:
崔龙慷 刘全 李振 李学飞 沈高波 方源 吴连国
1浙江中医药大学附属第二医院(杭州,310005)2浙江中医药大学△通信作者 E-mail:mdwu8535@126.com
Author(s):
CUI Longkang LIU Quan LI Zhen LI Xuefei SHEN Gaobo FANG Yuan WU Lianguo
1The Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310005,China; 2Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China.
关键词:
强骨饮;  老年女性;  骨质疏松症;  炎症细胞因子;  骨保护素;  核因子κB受体活化因子配体;  骨密度
Keywords:
Qiangguyin;  senile female;  osteoporosis;  inflammatory cytokines;  osteoprotegerin;  receptor activator of nuclear factor-κB Ligand;  bone mineral density
分类号:
R274.39
文献标志码:
A
摘要:
目的:观察口服中药强骨饮对骨质疏松症老年女性患者血清炎症细胞因子、骨保护素(OPG)、核因子κB受体活化因子配体(RANKL)及骨密度(BMD)的影响。方法:将符合要求的60例老年女性骨质疏松症患者随机分为观察组和对照组,对照组予以口服阿仑膦酸钠维D3片治疗,观察组予以口服中药强骨饮治疗,两组同时给予相同剂量阿法骨化醇软胶囊和碳酸钙D3片,两组均连续用药6个月。比较两组治疗前后中医证候积分、骨密度(BMD),于治疗前、治疗3个月后和治疗6个月后测定两组患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、巨噬细胞集落刺激因子(M-CSF)、骨保护素(OPG)和核因子κB受体活化因子配体(RANKL)水平,治疗结束后比较两组临床疗效,记录两组安全性指标及不良反应。结果:治疗后两组中医症候积分显著低于治疗前,差异有统计学意义(P<0.05),且观察组显著低于对照组(P<0.05); 观察组总有效率为93.33%,显著高于对照组70.00%,差异有统计学意义(P<0.05)。两组患者治疗前血清TNF-α,IL-6,M-CSF,OPG及RANKL相比,差异无明显统计学意义(P>0.05); 治疗3个月后血清炎症细胞因子和RANKL水平均下降,血清OPG水平均上升,与治疗前水平对比差异有统计学意义(P<0.05),且观察组血清炎症细胞因子和RANKL水平低于对照组,OPG水平高于对照组,差异有统计学意义(P<0.05); 治疗6个月后血清炎症细胞因子和RANKL水平继续下降,血清OPG水平继续上升,与治疗前及治疗后3个月水平对比差异有统计学意义(P<0.05),观察组血清炎症细胞因子和RANKL水平仍低于对照组,OPG水平仍高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者BMD比较,差异无统计学意义(P>0.05); 治疗6个月后,两组患者的BMD均较治疗前增高(P<0.05),且观察组BMD均高于对照组,差异有统计学意义(P<0.05)。结论:强骨饮能够有效降低骨质疏松症老年女性患者血清炎症细胞因子TNF-α,IL-6和M-CSF水平,且能够提升血清OPG水平并降低血清RANKL水平,强骨饮可以通过影响炎症细胞因子和OPG/RANKL/RANK系统干预骨代谢,提高骨量,从而发挥抗骨质疏松的作用。
Abstract:
To observe the influence of Qiangguyin on serum inflammatory cytokines and osteoprotegerin(OPG)and nuclear factor-κB receptor activator ligand(RANKL)and bone mineral density(BMD)in elderly female patients with osteoporosis.Methods:60 elderly female patients with osteoporosis were randomly divided into observation group and control group.Both groups were given the same dose of α calcidol soft capsules and calcium carbonate D3 tablets at the same time.The control group was treated with alendronate sodium vitamin D3 tablets while the observation group was treated with Qiangguyin.Both groups were treated for 6 months.traditional Chinese medicine(TCM)syndrome score and bone mineral density were compared between the two groups before and after treatment.The serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),macrophage colony-stimulating factor(M-CSF),OPG and RANKL were measured before treatment,3 months after treatment and 6 months after treatment.After treatment,the clinical efficacy of the two groups was compared,and the safety indexes and adverse reactions of the two groups were recorded.Results:After treatment,the score of TCM symptoms in the two groups was significantly lower than that before treatment(P<0.05),and the score in the observation group was significantly lower than that in the control group(P<0.05).The total effective rate of the observation group was 93.33%,which was significantly higher than that of the control group 70.00%(P<0.05).There was no significant difference in serum TNF-α,IL-6,M-CSF,OPG and RANKL between the two groups before treatment(P>0.05).After 3 months of treatment,the levels of serum inflammatory cytokines and RANKL decreased,while the levels of serum OPG increased,which were significantly higher than those before treatment(P<0.05).The levels of serum inflammatory cytokines and RANKL in the observation group were lower than those in the control group,while the level of OPG in the observation group was higher than that in the control group(P<0.05).After 6 months treatment,the levels of serum inflammatory cytokines and RANKL continued to decrease,while the levels of serum OPG continued to rise,which were significantly higher than those before treatment and 3 months after treatment(P<0.05).The levels of serum inflammatory cytokines and RANKL in the observation group were still lower than those in the control group,and the level of OPG in the observation group was still higher than that in the control group(P<0.05).There was no significant difference in BMD between the two groups before treatment(P>0.05).6 months after treatment,the BMD of the two groups was higher than that before treatment,and the BMD of the observation group was significantly higher than that of the control group(P<0.05).Conclusion:Qiangguyin can effectively reduce the levels of serum inflammatory cytokines TNF-α,IL-6 and M-CSF in elderly female patients with osteoporosis,and can increase the level of serum OPG and decrease the level of serum RANKL.Qiangguyin can interfere with bone metabolism and increase bone mass by affecting inflammatory cytokines and OPG/RANKL/RANK system,so as to play a role in anti-osteoporosis.

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备注/Memo

备注/Memo:
基金项目:浙江省中医药科技计划重点研究项目(2019ZZ012)国家中医临床研究基地支撑学科建设计划(中西医结合骨关节病防治学-2020-JDXK-ZC01)浙江省“十三五”中医药重点专科建设项目(外科-运动创伤科)(浙卫办中医〔2019〕1号)
更新日期/Last Update: 2021-03-15