[1]董锡亮 杨子斌 吕乔.脊柱手术后切口感染患者血清炎症因子变化及临床意义分析[J].中国中医骨伤科杂志,2020,28(07):43-46.
　DONG Xiliang YANG Zibin LYU Qiao.The Change and Clinical Significance of Serum Inflammatory Factors in Patients with Incision Infection after Spinal Surgery[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2020,28(07):43-46.
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脊柱手术后切口感染患者血清炎症因子变化及临床意义分析()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第28卷
期数:
2020年07期
页码:
43-46
栏目:
临床论著
出版日期:
2020-07-10

文章信息/Info

Title:
The Change and Clinical Significance of Serum Inflammatory Factors in Patients with Incision Infection after Spinal Surgery
文章编号:
1005-0205(2020)07-0043-04
作者:
董锡亮1 杨子斌1 吕乔1
1云南省大理州人民医院骨一科(云南 大理,671000)
Author(s):
DONG Xiliang1 YANG Zibin1 LYU Qiao1
1The First Department of Orthopedics,Dali City People's Hospital of Yunnan Province,Dali 671000,Yunnan China.
关键词:
脊柱手术;  切口感染;  炎症因子;  临床意义
Keywords:
spinal surgery;  incision infection;  inflammatory factors;  clinical significance
分类号:
R681.5
文献标志码:
A
摘要:
目的:探讨脊柱手术后切口感染患者血清炎症因子变化及临床意义。方法:选取2018年9月至2019年9月脊柱手术后患者658例,所有患者均检测血清炎症因子(高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白介素8(IL-8))水平,并通过细菌培养评估切口感染情况,分析炎症因子对脊柱手术后切口感染的临床意义。结果:658例脊柱手术后患者中,切口感染者有90例,感染率为13.68%; 感染者术后1,3 d血清hs-CRP,TNF-α,IL-8水平明显高于无感染者,差异有统计学意义(P<0.05); ROC曲线分析显示,在评估脊柱手术后切口感染的敏感度、特异度、准确度中,hs-CRP>20.4 mg/L时为84.44%,92.26%和91.19%,TNF-α>1.8 ng/mL时为82.22%,93.31%和91.79%,IL-8>11.5 pg/mL时为80.00%,91.55%和89.97%,hs-CRP,TNF-α,IL-8联合时为97.78%,98.59%和98.48%,hs-CRP,TNF-α,IL-8联合时明显高于hs-CRP,TNF-α,IL-8单独时,差异有统计学意义(P<0.05)。结论:hs-CRP,TNF-α,IL-8等血清炎症因子变化与脊柱手术后切口感染有关,可作为评估患者切口感染的重要指标,且三者联合时评估价值更高。
Abstract:
Objective:To explore the change and clinical significance of serum inflammatory factors in patients with incision infection after spinal surgery. Methods:658 patients who underwent spinal surgery in our hospital from September 2018 to September 2019 were selected,the serum levels of inflammatory factors(high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8))were detected in all patients,and the incision infection was evaluated by bacterial culture. The clinical significance of inflammatory factors on incision infection after spinal surgery was analyzed. Results:Among the 658 patients who underwent spinal surgery 90 patients had incision infection,and the infection rate was 13.68%. The serum levels of hs-CRP,TNF-α and IL-8 in infected patients at 1 and 3 days after operation were significantly higher than those in non-infected patients,the difference was statistically significant(P<0.05). The ROC curve analysis showed that,in the sensitivity,specificity and accuracy of evaluating incision infection after spinal surgery the hs-CRP>20.4 mg/L were 84.44%,92.26%,91.19%,the TNF-α>1.8 ng/mL were 82.22%,93.31%,91.79%,the IL-8 > 11.5 pg/mL were 80.00%,91.55%,89.97%,the hs-CRP,TNF-α and IL-8 combined were 97.78%,98.59%,98.97%. The hs-CRP,TNF-α and IL-8 combined were significantly higher than the hs-CRP,TNF-α and IL-8 alone,the difference was statistically significant(P<0.05). Conclusion:The change of serum inflammatory factors such as hs-CRP,TNF-α and IL-8 are related to incision infection after spinal surgery,which can be used as the important index for evaluating incision infection in patients,and the combination of them has higher evaluation value.

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备注/Memo

备注/Memo:
(收稿日期:2019-10-10)
更新日期/Last Update: 2020-07-10