[1]祁兆建 韩廷成 陈大志 顾荣胜 孟庆国 陆华 范广峰 田敏△ 沈龙祥.骨痹灵片治疗膝关节骨性关节炎临床疗效观察[J].中国中医骨伤科杂志,2018,26(09):32-35，40.
　QI Zhaojian HAN Tincheng CHEN Dazhi GU Rongsheng MENG Qingguo LU Hua FAN Guangfeng TIAN Min SHEN Longxiang.Clinical Observation of Gubiling Tablets in the Treatment of Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2018,26(09):32-35，40.
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骨痹灵片治疗膝关节骨性关节炎临床疗效观察()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第26卷
期数:
2018年09期
页码:
32-35，40
栏目:
临床研究
出版日期:
2018-09-06

文章信息/Info

Title:
Clinical Observation of Gubiling Tablets in the Treatment of Knee Osteoarthritis
文章编号:
1005-0205(2018)09-0032-04
作者:
祁兆建1 韩廷成1 陈大志1 顾荣胜1 孟庆国1 陆华1 范广峰1 田敏1△ 沈龙祥2
1江苏盐城市中医院骨伤一科(江苏 盐城,224001) 2上海交通大学附属第六人民医院骨科
Author(s):
QI Zhaojian1 HAN Tincheng1 CHEN Dazhi1 GU Rongsheng1 MENG Qingguo1 LU Hua1 FAN Guangfeng1 TIAN Min1△ SHEN Longxiang2
1Department of Orthopaedics,Yancheng Hospital of Traditional Chinese Medicine,Yancheng 224001,Jiangsu China; 2The Sixth Peple's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China.
关键词:
膝关节骨性关节炎;  中医药疗法;  骨痹灵片
Keywords:
Keywords: knee osteoarthritis;  Chinese medicine therapy;  gubiling tablets
分类号:
R684.3
文献标志码:
A
摘要:
目的:观察自制中成药骨痹灵片治疗膝关节骨性关节炎的临床疗效。方法:将60例膝关节骨性关节炎患者随机分为治疗组和对照组。治疗组口服骨痹灵片,对照组口服盐酸氨基葡萄糖片,连服4周。结果:1)两组患者治疗后疼痛症状均较治疗前明显减轻,两组治疗前后VAS评分差异有统计学意义(P<0.01),治疗组和对照组差异无统计学意义(P>0.05).2)与治疗前相比,两组在疼痛、僵硬、功能以及WOMAC总评分上均有明显改善,差异有统计学意义(P<0.05)。在疼痛评分差值上,两组治疗前后相比,差异无统计学意义(P>0.05),表明治疗组与对照组在改善疼痛方面疗效相近。两组治疗前后僵硬、功能活动以及WOMAC总评分差值比较,差异有统计学意义(P<0.05),说明在改善僵硬、功能方面,治疗组具有优势,且总的治疗效果治疗组优于对照组。3)两组患者停药4周与治疗前WOMAC评分差异均有统计学意义(P<0.05),停药4周与治疗后WOMAC评分比较,治疗组差异无统计学意义(P>0.05),对照组差异有统计学意义(P<0.05),说明两种药物对于本病均有治疗效果,但治疗组的近期及远期疗效均优于对照组。4)治疗组的总有效率为93.3%,对照组为83.3%,说明治疗组疗效明显优于对照组,差异有统计学意义(P<0.05).结论:骨痹灵片可以治疗膝关节骨性关节炎,在改善膝关节疼痛症状方面,与盐酸氨基葡萄糖片效果相近,而在改善膝关节僵硬及功能活动方面,骨痹灵片具有更明显优势。
Abstract:
Abstract Objective:To observe the clinical effect of self-made Chinese medicine Gubiling tablets in the treatment of knee osteoarthritis.Methods:60 patients with knee osteoarthritis were randomly divided into treatment group and control group.In the treatment group,Gubiling tablets were taken,and the control group took Glucosamine hydrochloride tablets for 4 weeks.Results:1)the pain symptoms of the two groups reduced obviously after the treatment and there was significant difference in the VAS scores of the two groups before and after treatment(P<0.01),and there was no significant difference between the treatment group and the control group(P>0.05).2)The two groups showed significant improvement in pain,stiffness,function and total WOMAC score after treatment(P<0.05).In the difference of pain score,there was no statistical difference between the two groups before and after treatment(P>0.05),indicating that the two groups had similar efficacy in improving pain.The difference of stiffness,function and WOMAC total score of the two groups before and after treatment had statistical difference(P<0.05),indicating that the treatment group had advantages in improving stiffness and function,and the total therapeutic effect is better in the treatment group than in the control group. 3)After stopping for four weeks,there were statistically significant differences in the WOMAC scores before and after treatment in both groups(P<0.05).Compared with the WOMAC scores four weeks ago,there was no significant difference in the treatment group(P>0.05),and the control group had statistical difference(P<0.05).It means both medications have a therapeutic effect on the disease,but the recent and forward curative effect of treatment group was better than that of the control group.4)The total effective rate of the treatment group was 93.3%,and 83.3% in the control group,indicating that the efficacy of the treatment group was significantly better than that of the control group(P<0.05).Conclusion:Gubiling tablets can treat knee osteoarthritis.It is similar to Glucosamine hydrochloride tablets on improving pain symptom of knee joint,and is of great advantage in improving knee joint stiffness and function.

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备注/Memo

备注/Memo:
基金项目:江苏省中医药管理局科技项目:苏中科教 (2015)9号(YB2015131) △通信作者 E-mail:thawgem@163.com
更新日期/Last Update: 2018-09-06