[1]石晓兵△ 支晓丞 吴小建 彭程 李国中.医用几丁糖分期治疗膝骨性关节炎的临床研究[J].中国中医骨伤科杂志,2018,26(06):48-50，55.
　SHI Xiaobing ZHI Xiaochen WU Xiaojian PENG Cheng LI Guozhong.Clinical Study of Chitosan in the Treatment of Knee Osteoarthritis at Stages[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2018,26(06):48-50，55.
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医用几丁糖分期治疗膝骨性关节炎的临床研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第26卷
期数:
2018年06期
页码:
48-50，55
栏目:
临床论著
出版日期:
2018-06-02

文章信息/Info

Title:
Clinical Study of Chitosan in the Treatment of Knee Osteoarthritis at Stages
文章编号:
1005-0205(2018)06-0048-03
作者:
石晓兵1△ 支晓丞1 吴小建1 彭程1 李国中1
1上海市宝山区中西医结合医院(上海,201999 ) △通信作者 E-mail:shixb2005@126.com
Author(s):
SHI Xiaobing1△ ZHI Xiaochen1 WU Xiaojian1 PENG Cheng1 LI Guozhong1
1Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, China.
关键词:
几丁糖;  膝骨性关节炎;  分期治疗
Keywords:
Keywords: chitosan;  knee osteoarthritis;  stage therapeutics
分类号:
R684.3
文献标志码:
A
摘要:
目的:探讨医用几丁糖对膝骨性关节炎的临床分期治疗效果。方法:根据临床症状、体征及 Kellgren/ Lawrence诊断标准将膝骨性关节炎分为4期(Ⅰ期,Ⅱ期,Ⅲ期和Ⅳ期),对随机入选的386例膝骨性关节炎患者进行分期后对应分为 A,B,C和D四组,采取膝关节内注射医用几丁糖治疗1个疗程。治疗后1个月,采用WOMAC,VAS量表评分及临床总有效率来比较、分析各组治疗前及治疗后的临床疗效。结果:治疗后1个月,4组WOMAC评分及VAS评分与治疗前比较均有显著下降,差异有统计学意义(P<0.05); 临床总有效率:A组100%,B组94.90%,C组66.67%和D组59.57%.A组和B组的治疗总有效率明显高于C组和D组,差异有统计学意义(P<0.05); 对A组和B组,C组和D组之间的临床总有效率进行比较,差异无统计学意义(P>0.05)。结论:医用几丁糖能有效治疗膝骨性关节炎,对膝骨性关节炎Ⅰ期和Ⅱ期的临床疗效明显优于Ⅲ期和Ⅳ期,分期治疗膝骨性关节炎对临床合理使用医用几丁糖有积极的指导意义。
Abstract:
Abstract Objective: To analyze the clinical efficacy of chitosan in the treatment of knee osteoarthritis at clinical stages. Methods: According to clinical symptoms, signs and Kellgren/Lawrence diagnostic criteria, Knee osteoarthritis was divided into four periods(Ⅰ period, Ⅱperiod, Ⅲ period, Ⅳperiod). The 386 patients with knee osteoarthritis being randomly selected were divided into four groups: A, B, C and D group. A course of treatment of chitosan was used in the knee joint injection. One month after treatment, by using WOMAC, VAS scale score and clinical total efficiency, the clinical efficacy of each group before and after treatment were compared and analyzed. Results: One month after treatment, four groups of WOMAC scores and VAS scores were significantly lower than those before treatment, the difference was statistically significant(P<0.05). Clinical total efficiency: group A was 100%, group B 94.90%, group C 66.67%, group D 59.57%. The total effective treatment of group A and group B was significantly higher than that of group C and group D, the difference was statistically significant(P<0.05). Comparing the total clinical effectiveness between group A and group B, group C and group D, the difference was not statistically significant(P<0.05). Conclusion: Chitosan can effectively treat knee osteoarthritis. The clinical curative effect of knee osteoarthritisⅠ,Ⅱ period was obviously better than that of knee osteoarthritis Ⅲ, Ⅳ period. Treatment of knee osteoarthritis by stages has positive guiding significance for the rational use of chitosan in clinic.

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备注/Memo

备注/Memo:
基金项目:上海市卫生与计划生育委员会项目 (ZY3-FWMS-2-1001)
更新日期/Last Update: 2018-06-02