[1]陈晓东 翟明玉△ 欧传双 赵海博 舒高.补气通络法对脊髓型颈椎病术后Aβ蛋白、ET及NO表达的影响[J].中国中医骨伤科杂志,2018,26(04):18-23，28.
　CHEN Xiaodong ZHAI Mingyu OU Chuanshuang ZHAO Haibo SHU Gao.Effect of Buqi Tongluo Method on Aβ Protein, ET and NO Expression after Operation of Cervical Spondylotic Myelopathy[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2018,26(04):18-23，28.
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补气通络法对脊髓型颈椎病术后Aβ蛋白、ET及NO表达的影响()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第26卷
期数:
2018年04期
页码:
18-23，28
栏目:
临床研究
出版日期:
2018-04-10

文章信息/Info

Title:
Effect of Buqi Tongluo Method on Aβ Protein, ET and NO Expression after Operation of Cervical Spondylotic Myelopathy
文章编号:
1005-0205(2018)04-0018-06
作者:
陈晓东1 翟明玉1△ 欧传双1 赵海博1 舒高1
1深圳平乐骨伤科医院(广东 深圳,518000)
Author(s):
CHEN Xiaodong1 ZHAI Mingyu1△ OU Chuanshuang1 ZHAO Haibo1 SHU Gao1
1 Shenzhen Pingle Orthopedic Hospital, Shenzhen 518000,Guangdong China.
关键词:
脊髓型颈椎病;  补阳还五汤;  血管内皮素;  一氧化氮;  Aβ蛋白
Keywords:
Keywords:cervical spondylotic myelopathy;  Buyang Huanwu decoction;  endothelin;  nitric oxide;  Aβ protein
分类号:
R681.5
文献标志码:
A
摘要:
目的:通过探讨补气通络法对脊髓型颈椎病术后Aβ蛋白、ET及NO表达的影响,研究脊髓型颈椎病神经损伤病理变化及术后中医药对神经损伤修复的干预机制。方法:将60例确诊为脊髓型颈椎病患者,随机分为A组(对照组)及B组(治疗组)各30例,两组患者均采用手术治疗。A组,术后常规治疗,B组,术后第2天补阳还五汤口服+术后常规治疗。检测术后血液中不同时间点的Aβ蛋白、ET及NO相关指标,颈椎JOA评分,术前与术后第4周肌电图检测神经根损伤情况; 比较两组间治疗前后不同时间节点各个指标变化情况。结果:治疗组比较对照组,在术后第1周和第4周血液中ET和NO降低,差异有统计学意义(P<0.05)。术后1周血液中Aβ蛋白变化,差异无统计学意义(P>0.05); 术后第4周血液中Aβ蛋白降低,差异有统计学意义(P<0.05)。术后第1周、第4周颈椎JOA评分差异有统计学意义(P<0.05)。术后第4周肌电图检测神经根损伤阳性情况:治疗组阳性患者3例,对照组阳性患者10例,差异有统计学意义(P<0.05)。结论:采用中医补气通络法,口服补阳还五汤能够使髓型颈椎病术后患者血液中ET和NO降低,对血液中Aβ蛋白含量有动态调节作用; 说明补阳还五汤对参与脊髓型颈椎病术后神经功恢复的理化因子有调节作用,对术后神经功能恢复有积极作用。
Abstract:
Abstract Objective:To study the effect of Buqi Tongluo therapy on the expression of Aβ protein, ET and NO after surgery of cervical spondylosis, and to investigate the pathological changes of nerve injury and the intervention mechanism of traditional Chinese medicine on nerve injury after operation. Methods: 60 cases of cervical spondylotic myelopathy were randomly divided into group A(control group)and group B(treatment group), 30 cases in each group. Both groups received surgery.Patients in group A were given postoperative routine treatment,while patients in group B were administrated Buyang Huanwu decoction and postoperative routine treatment 2 days after surgery. The indexes such as Aβ protein, ET and NO in the blood and cervical JOA score were measured at different time points after operation. The nerve root damage was detected by electromyography before and 4 weeks after operation. The changes of each index were compared between the two groups before and after treatment. Results: Compared with the control group, the blood ET and NO in the treatment group were decreased at 1 weeks and 4 weeks after the operation, and the difference was statistically significant(P<0.05); 1 week after operation, the changes of A beta protein in the blood of the treatment group were not statistically significant(P>0.05).After 4 weeks of operation, the A beta protein in the blood of the treatment group decreased, and the difference was statistically significant(P<0.05). There was significant difference in JOA score between two groups at 1 week and 4 weeks after the operation(P<0.05).At 4 weeks after operation, electromyogram was used to detect the nerve root injury: there were 3 positive patients in the treatment group and 10 in the control group, with significant difference(P<0.05). Conclusion: Administration of Buyang Huanwu decoction for Buqi Tongluo method can reduce ET and NO in blood of patients with cervical spondylotic myelopathy, and regulate Aβprotein content in blood dynamically.It indicates that Buyang Huanwu decoction has a regulatory effect on physical and chemical factors involved in neurological recovery, and has a positive clinical effect on postoperative neurological function recovery.

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备注/Memo

备注/Memo:
基金项目:广东省中药局课题项目(20162118) △通信作者 E-mail:756661224@qq.com
更新日期/Last Update: 2018-04-15