[1]郭珈宜 范仪铭 崔宏勋 李峰 郭艳幸.平乐正骨活血灵方联合低剂量利伐沙班预防髋部大手术下肢深静脉血栓的临床观察[J].中国中医骨伤科杂志,2018,26(03):17-20.
　GUO Jiayi FAN Yiming CUI Hongxun LI Feng GUO Yanxing.The Efficacy and Safety of Pingle Huoxueling Decoction Combined with Low Dose Rivaroxaban in Prevention of Deep Venous Thrombosis of Lower Extremity in Orthopedics Surgery[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2018,26(03):17-20.
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平乐正骨活血灵方联合低剂量利伐沙班预防髋部大手术下肢深静脉血栓的临床观察()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第26卷
期数:
2018年03期
页码:
17-20
栏目:
临床研究
出版日期:
2018-03-05

文章信息/Info

Title:
The Efficacy and Safety of Pingle Huoxueling Decoction Combined with Low Dose Rivaroxaban in Prevention of Deep Venous Thrombosis of Lower Extremity in Orthopedics Surgery
文章编号:
1005-0205(2018)03-0017-04
作者:
郭珈宜1 范仪铭2 崔宏勋1 李峰1 郭艳幸1
1河南省洛阳正骨医院(河南省骨科医院)(河南 洛阳,471000)
2湖南中医药大学
Author(s):
GUO Jiayi1 FAN Yiming2 CUI Hongxun1 LI Feng1 GUO Yanxing1
1Luoyang Orthopedic Hospital, Luoyang 471000,Henan China;
2Hunan University of Traditional Chinese Medicine, Changsha 410000,China.
关键词:
平乐活血灵;  利伐沙班;  深静脉血栓;  骨科大手术
Keywords:
Pingle Huoxueling;  Rivaroxaban;  deep venous thrombosis;  orthopedics major surgery
分类号:
R364.1
文献标志码:
A
摘要:
目的:观察平乐正骨活血灵方与低剂量利伐沙班预防髋部大手术下肢深静脉血栓(DVT)的临床疗效并评价其安全性。方法:将106例行髋部大手术患者随机分为试验组和对照组,各53例。试验组口服活血灵汤,同时口服低剂量利伐沙班,对照组口服正常剂量利伐沙班,连续治疗2周。观察两组患者血流变、凝血指标、血栓发生率及用药安全情况。结果:试验组和对照组术后APTT和PT均明显延长,差异有统计学意义(P<0.05); D-D和患肢大腿周径差值均明显降低,差异有统计学意义(P<0.05); 两组间比较,差异无统计学意义(P>0.05); 两组患者术中出血量、 输血量及术后引流量比较,差异均无统计学意义(P>0.05); 试验组下肢深静脉血栓发生率为7.54%,对照组为5.66%,差异无统计学意义(P>0.05)。结论:应用平乐正骨活血灵联合低剂量利伐沙班预防髋部术后DVT,能减少利伐沙班用量、降低DVT发生率,有效性和安全性与正常剂量利伐沙班相当。
Abstract:
Objective:To observe the clinical efficacy and safety of Pingle Huoxueling decoction combined with low dose Rivaroxaban in prevention of deep venous thrombosis of lower extremity in orthopedics surgery. Methods:106 cases undergoing major hip surgery were randomly divided into experimental group and control group, 53 cases in each group.The experimental group was given oral Huoxueling decoction combined with low dose Rivaroxaban, and the control group was given normal dose Rivaroxaban for 2 weeks. The blood rheology, coagulation, thrombosis and medication safety were observed in the two groups. Results: The APTT and PT in both groups were significantly prolonged after operation(P<0.05), and the reduction of leg circumference at thigh and the D-D in both groups was significantly decreased(P<0.05). There was no statistically significant difference between the two groups(P>0.05).There was no statistically difference in the amount of bleeding, blood transfusion and postoperative drainage between the two groups(P>0.05).The incidence of deep venous thrombosis in experimental group was 7.54%, and in control group 5.66%, there was no statistically significant difference between the two groups(P>0.05).Conclusion: Pingle Huoxueling decoction combined with low dose Rivaroxaban can reduce the dosage of Rivaroxaban and the incidence of DVT after hip surgery, its effectiveness and safety are comparable to that of the normal dosage Rivaroxaban.

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备注/Memo

备注/Memo:
基金项目:河南省科技厅“国家非物质文化遗产—平乐郭氏 正骨术的系统研究与开发” 项目(112102310008) 2016年河南省科技发展计划项目(162102310365)
△通信作者 E-mail:295416624@qq.com
更新日期/Last Update: 2018-03-15