[1]王彦鹏,孙明林△,张伟.Dickkopf相关蛋白1水平与膝骨关节炎影像学分级的相关性[J].中国中医骨伤科杂志,2017,25(09):22-24,29.
　WANG,Yanpeng,SUN,et al.Correlationship between Level of Dickkopf-1 and Radiographic Grading of Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2017,25(09):22-24,29.
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Dickkopf相关蛋白1水平与膝骨关节炎影像学分级的相关性()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第25卷
期数:
2017年09期
页码:
22-24,29
栏目:
临床研究
出版日期:
2017-09-08

文章信息/Info

Title:
Correlationship between Level of Dickkopf-1 and Radiographic Grading of Knee Osteoarthritis
文章编号:
1005-0205(2017)09-0022-03
作者:
王彦鹏1; 孙明林1△; 张伟2
1武警后勤学院附属医院骨科中心(天津,300162) 2武警上海总队第七支队后勤处卫生处
Author(s):
WANG; Yanpeng1; SUN; Minglin1Δ; ZHANG; Wei2
1Department of Orthopedics,Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, China; 2Medical Team, The Seventh Detachment of Armed Police Force of Shanghai, Shanghai 201900, China.
关键词:
膝骨关节炎;  Dickkopf相关蛋白1;  凯尔格伦-劳伦斯分级
Keywords:
knee osteoarthritis;  Dickkopf-1;  Kellgren-Lawrence classification
分类号:
R684
文献标志码:
A
摘要:
目的:探讨血清和关节滑液中Dickkopf相关蛋白1(DKK-1)水平与膝骨关节炎(KOA)患者影像学分级严重程度的相关性。方法:纳入50例KOA患者为观察组,同期健康体检者20例为对照组,采用ELISA法检测两组血清和观察组关节液中DKK-1水平。膝骨关节炎影像学严重程度分级采用Kellgren-Lawrence评分系统。分析血清和膝关节滑液DKK-1水平与KOA严重程度的相关性。结果:KOA患者不同分级组及正常对照组血清DKK-1水平比较,差异有统计学意义(F=13.85,P<0.001); 不同分级KOA患者血清及关节滑液DKK-1水平差异有统计学意义(F=17.678,P<0.001; F=13.978,P<0.001); 血清及关节滑液DKK-1水平随着K-L分级越高而降低(P<0.05); 血清和关节滑液中DKK-1水平与K-L分级有相关性(r=-0.731,P<0.001; r=-0.690,P<0.001); 血清DKK-1水平与关节滑液DKK-1水平呈正相关性(r=0.725,P<0.001)。结论:KOA患者血清和关节滑液DKK-1水平显著降低,与K-L分级呈负相关。
Abstract:
Abstract Objective:To investigate the correlationship between the level of serum and synovia Dickkopf-1(DKK-1)and radiographic grading of Knee Osteoarthritis(KOA). Methods:50 patients with KOA were enrolled into this study as observation group, and 20 healthy subjects as the control group. The levels of serum and synovia DKK-1 were determined by enzyme-linked immunosorbent assay. Radiographic grading of KOA was performed according to the Kellgren-Lawrence(K-L)classification. Correlations between the level of serum and synovia DKK-1 and severity of KOA were analyzed. Results: The serum DKK-1 levels of KOA patients were significantly different between grading groups and normal control group(F=13.85, P<0.001). The levels of serum and synovia DKK-1 between patients with different grades of KOA were significantly different(F=17.678,P<0.001; F=13.978,P<0.001).The levels of serum and synovia DKK-1 decreased with increasing severity of K-L grading(P<0.05 or 0.01). The levels of serum and synovia DKK-1 were negitively correlated with the severity grade of K-L(r=-0.731, P<0.001; r=-0.690,P<0.001). The levels of serum DKK-1 was positively correlated with the levels of synovia DKK-1(r=0.725, P<0.001). Conclusion: The levels of serum and synovia DKK-1 were extremely decreased in the patients with KOA, which were negitively correlated with K-L classification.

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备注/Memo

备注/Memo:
1武警后勤学院附属医院骨科中心(天津,300162) 2武警上海总队第七支队后勤处卫生处 △通信作者 E-mail:165318413@qq.com
更新日期/Last Update: 1900-01-01