[1]刘冰△ 高兆宾 赵亮亮.膝骨关节炎患者血清和关节滑液TWEAK水平与影像学严重程度的相关性[J].中国中医骨伤科杂志,2017,25(04):18-21.
　LIU Bing GAO Zhaobin ZHAO Liangliang.Association of TWEAK Level in Serum and Synovia with X-ray Severity in Knee Osteoarthritis Patients[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2017,25(04):18-21.
点击复制

膝骨关节炎患者血清和关节滑液TWEAK水平与影像学严重程度的相关性()
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第25卷
期数:
2017年04期
页码:
18-21
栏目:
临床研究
出版日期:
2017-04-06

文章信息/Info

Title:
Association of TWEAK Level in Serum and Synovia with X-ray Severity in Knee Osteoarthritis Patients
文章编号:
1005-0205(2017)04-0018-04
作者:
刘冰1△ 高兆宾1 赵亮亮1
1.北京市丰台区中西医结合医院(北京,100072)
△.通信作者 E-mail:bjftcb88@qq.com
Author(s):
LIU Bing1△ GAO Zhaobin1 ZHAO Liangliang1
1.Department of Orthopaedics,Beijing Fengtai Hospital of Integrated Traditional and Western Medicine,Beijing 100072,China.
关键词:
骨关节炎;  肿瘤坏死因子样弱凋亡诱导因子;  Kellgren-Lawrence分级
Keywords:
osteoarthritis;  tumor necrosis factor-like weak inducer of apoptosis;  Kellgren-Lawrence classification
分类号:
R684.3
文献标志码:
A
摘要:
目的:探讨膝骨关节炎(Osteoarthritis,OA)患者血清和关节滑液中肿瘤坏死因子样弱凋亡诱导因子(Tumor Necrosis Factor-like Weak Inducer of Apoptosis,TWEAK)水平与OA 患者X线片上Kellgren-Lawrence(K-L)分级严重程度的相关性。方法:选取本院就诊的58例OA患者为OA组,健康对照者30例为对照组,膝骨关节炎影像学严重程度评分采用国际公认的Kellgren-Lawrence评分系统。采用酶联免疫吸附测定法检测两组血清和OA组关节液中TWEAK水平。分析血清和膝关节滑液TWEAK水平与OA严重程度的相关性。结果:OA组血清TWEAK水平明显高于对照组,差异有统计学意义(P<0.01); OA患者关节滑液TWEAK水平显著高于血清水平,差异有统计学意义(P<0.01); 在OA患者中,K-L分级越高,血清及关节滑液TWEAK水平越高(P<0.05或0.01); 血清和关节滑液中TWEAK水平与OA患者的K-L分级呈显著相关性(r=0.574,P<0.001; r=0.651,P<0.001); 血清TWEAK水平与关节滑液之间呈显著相关性(r=0.865,P<0.001)。结论:TWEAK水平与OA患者影像学K-L分级严重程度正相关,可作为评价OA严重程度的参考指标。
Abstract:
Objective:To explore the correlationship between the level of tumor necrosis factor-like weak inducer of apoptosis(TWEAK)in serum and synovia and X-ray severity in patients with knee Osteoarthritis(OA).Methods:58 patients with OA and 30 healthy controls were enrolled into this study.Knee OA grading was performed according to the Kellgren-Lawrence(K-L)classification.The serum and synovial fluid levels of TWEAK were determined by enzyme-linked immunosorbent assay.Correlations between plasma and synovial influid levels of TWEAK and severity of OA were calculated.Results:The serum level of TWEAK in OA group was extremely higher than that in control group(P<0.01),and the synovial fluid level of TWEAK was higher significantly than the serum level of TWEAK(P<0.01).The higher the K-L classification,the higher the levels of serum and synovial fluid TWEAK.Both serum and synovial fluid levels of TWEAK were positively correlated with the severity grade of K-L for OA(respectively r=0.574,P<0.001; r=0.651,P<0.001).Furthermore,the level of serum TWEAK was positively correlated with the level of synovial fluid TWEAK(r=0.865,P<0.001).Conclusion:The level of TWEAK is postively correlated with the K-L classification,and may be used as a reference marker of severity of knee OA.

参考文献/References:

[1] 李宁,王拥军,施杞,等.膝骨性关节炎的中医药防治研究进展[J].中国中医骨伤科杂志,2013,21(5):62-65.
[2] Xu WD,Zhao Y,Liu Y.Role of the TWEAK/Fn14 pathway in autoimmune diseases[J].Immunol Res,2016,64(1):44-50.
[3] Dionne S,Levy E,Levesque D,et al.PPAR gamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis[J].Anticancer Res,2010,30(1):157-166.
[4] Winkles JA.The TWEAK-Fn14 cytokine-receptor axis:discovery,biology and therapeutic targeting[J].Nat Rev Drug Discov,2008,7(5):411-425.
[5] 陈悦,赵明才.肿瘤坏死因子样凋亡微弱诱导剂在骨关节炎中的作用[J].中华临床医师杂志:电子版,2011,5(18):5392-5496.
[6] 中华医学会骨科分会.骨关节炎诊治指南(2007年版)[J].中华骨科杂志,2007,27(10):793-796.
[7] Zhang Z,Fang Y,Wang Q,et al.Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway[J].Mol Med Rep,2015,12(1):1499-1505.
[8] Cherry EM,Lee DW,Jung JU,et al.Tumor necrosis factor-like weak inducer of apoptosis(TWEAK)promotes glioma cell invasion through induction of NF-κB-inducing kinase(NIK)and noncanonical NF-κB signaling[J].Mol Cancer,2015,14:9.
[9] 蔡国平,俞永林,熊敏,等.TWEAK及其受体Fn14在大鼠骨关节炎(OA)关节软骨和滑膜中的表达[J].复旦学报:医学版,2013,40(3):265-270.
[10] 陈琼,赵明才,蒋萍,等.TWEAK/Fn14在骨关节炎患者中的表达及其临床意义[J].川北医学院学报,2013,28(4):302-304.
[11] Park JS,Park MK,Lee SY,et al.TWEAK promotes the production of Interleukin-17 in rheumatoid arthritis[J].Cytokine,2012,60(1):143-149.
[12] Perper SJ,Browning B,Burkly LC,et al.TWEAK is a novel arthritogenic mediator[J].J Immunol,2006,177(4):2610-2620.
[13] Kumar A,Bhatnagar S,Paul PK.TWEAK and TRAF6 regulate skeletal muscle atrophy[J].Curr Opin Clin Nutr Metab Care,2012,15(3):233-239.
[14] 陈雱,陈悦,王梓,等.肿瘤坏死因子样弱凋亡诱导因子在骨关节炎软骨细胞的表达及诱导产生MMP-9的研究意义[J].中华临床医师杂志:电子版,2012,6(10):2614-2617.
[15] 陈琼,赵明才,蒋萍,等.肿瘤坏死因子样微弱凋亡诱导因子对骨关节炎软骨细胞作用实验研究[J].检验医学与临床,2013,10(16):2065-2066.

更新日期/Last Update: 2017-04-07