参考文献/References:
[1] Peterson I,Jacobsson L,Silman L,et al.The epidemiology of osteoarthritis of peripheral joints[J].Ann Rheum Dis,1996,55(9):651-694.
[2] 李楠,雒焕生,赵诣,等.龟鹿二仙胶汤及其拆方对大鼠软骨细胞凋亡基因表达的影响[J].中国中医骨伤科杂志,2011,19(7):1-3.
[3] 李楠,雒焕生,尹玉彪,等.龟鹿二仙胶及其拆方含药血清对硝普钠诱导的大鼠软骨细胞bax、bcl-2表达的影响[J].中国中医骨伤科杂志,2012,20(1):1-4.
[4] 王和鸣,余丹丹,汤亭亭,等.龟鹿二仙胶汤及其拆方对关节软骨细胞增殖的作用[J].中国中医骨伤科杂志,2007,15(7):45-49.
[5] 李楠,雒焕生,赵诣,等.龟鹿二仙胶及其拆方对SD大鼠及豚鼠软骨细胞增殖的比较研究[J].中国中医骨伤科杂志,2011,19(8):1-2.
[6] 余添赐.龟鹿二仙胶不同提取部位对体外培养脉鼠关节软骨细胞活性的影响[D].福州:福建中医药大学,2014.
[7] 杜江,黄远鹏,李奕修,等.龟鹿二仙胶及其拆方对去势骨关节炎大鼠血清雌二醇浓度及膝关节软骨细胞II型胶原表达的影响[J].中医正骨,2013,25(3):11-20.
[8] LongDL LoeserRF.p38gamma mitogen- activated protein kinase suppresses chondrocyte production of MMP -13 in response to catabolic stimulation[J].Osteoarthritis Cartilage,2010,18(9):1203-1210.
[9] Joos,H Albrecht W,Laufer S,et al.Differential effects of p38 MAP kinase inhibitors on the expression of inflammation-associated genes in primary,interleukin-1beta-stimulated human chondro-cytes[J].Br J Pharmacol,2010,160(5):1252-1262.
[10] 张秀莲,程艳梅,朱生樑.p38 MAPK与疼痛敏感化[J].中华中医药,2014,29(10):3184-3187.
[11] 梁震,姜旭,吴成爱,等.雌性豚鼠不同年龄自发骨性关节炎的研究[J].中国骨质疏松杂志,2012,18(12):1091-1094.
[12] 蓝旭,刘雪梅,葛宝丰,等.豚鼠原发性骨关节炎的生化研究[J].中国骨伤,2001,14(4):212-213.
[13] 高世超,殷海波,刘宏潇,等.MAPK信号通路在骨关节炎发病机制中的研究进展[J].中国骨伤,2014,27(5):441-444.
[14] Lim H,Kim HP.Matrix metalloproteinase-13expression in IL-1-treated chondrocytes byactivation of the p38 MAPK/c- Fos/AP- 1 and JAK/STAT pathways[J].Arch Pharm Res,2011,34(1):109-117.
[15] Hamamura K,Goldring MB,Yokota H.Involvement of p38 MAPK In regulation of MMP13 mRNA in chondrocytes in response to sur-viving stress to endoplasmic reticulum [J].Arch Oral Biol,2009,54(3):279-286.
[16] Wei L,Sun XJ,Wang Z,et al.CD95- induced osteoarthritic chon-drocyte apoptosis and necrosis; dependency on p38 mitogen -acti-vated protein kinase[J].Arthritis Res Ther,2006,8(2):R37.
[17] 田佳,王文雅,张柳.参与骨关节炎的P38丝裂原活化蛋白激酶信号转导通路[J].中国组织工程研究,2013,17(28):5243-5248.
[18] 张林,陆军,李永刚.骨关节炎中介导软骨细胞代谢失衡的相关信号通路研究进展[J].东南大学学报:医学版,2013,32(4):465-472.
[19] Yoon HS,Kim HA.Prologation of c -Jun N- terminal kinase is associated with cell death induced by tumor necrosis factor alpha in human chondrocytes[J].J Korean Med Sci,2004,19(4):567-573.
[20] 涂玥,孙伟,万毅刚,等.大黄附子汤调控JNK/Bcl-2信号通路而改善尿酸性肾病肾小管/间质损伤的机制[J].中华中医药,2013,28(5):1351-1356.